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Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin | |
Meng, Xiaolu1,2; Shen, Fang1; Li, Chunlu1,2; Li, Yonghui1; Wang, Xuewei3 | |
第一作者 | Meng, Xiaolu ; Shen, Fang |
通讯作者邮箱 | shenf@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Tree shrews, a species phylogenetically close to primates, are regarded as a suitable and naturalistic animal model for depression studies. However, psychological symptoms that are essential for depression diagnosis and treatment, such as helplessness and social withdrawal, have not been studied in this model. Therefore, in this study, we first investigated learned helplessness, social interaction and sucrose preference induced by two chronic stress paradigms: uncontrollable foot shocks (1-week foot shocks) and multiple unpredictable stimuli (1-week foot shocks and 3-week unpredictable stressors) in tree shrews. Our results showed that uncontrollable foot shocks could only induce learned helplessness in animals; whereas animals treated with multiple unpredictable stimuli exhibited more depression-like behaviors including social withdrawal, anhedonia and learned helplessness. These findings suggested that multiple unpredictable stimuli could effectively induce various depression-like behaviors in tree shrews. More importantly, we compared the antidepressant effects of fluoxetine and carbetocin, a long-acting oxytocin analog, on specific depression-like behaviors. Our present data displayed that, compared with fluoxetine, carbetocin was also effective in reversing learned helplessness, elevating sucrose preference and improving social interaction behaviors in depression-like animals. Therefore, carbetocin might be a potential antidepressant with applications in humans. (C) 2016 Elsevier Inc. All rights reserved. |
关键词 | Depression-like Behaviors Tree Shrews Uncontrollable Foot Shocks Chronic Unpredictable Stress Carbetocin |
2016-06-01 | |
语种 | 英语 |
DOI | 10.1016/j.pbb.2016.03.006 |
发表期刊 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR |
ISSN | 0091-3057 |
卷号 | 145期号:0页码:1-8 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | CHRONIC PSYCHOSOCIAL STRESS ; LEARNED HELPLESSNESS ; TUPAIA-BELANGERI ; MAJOR DEPRESSION ; SEXUAL-BEHAVIOR ; BRAIN OXYTOCIN ; MALE-RATS ; ANTIDEPRESSANT ; SYSTEM ; VASOPRESSIN |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy |
WOS类目 | Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy |
WOS记录号 | WOS:000377326300001 |
Q分类 | Q2 |
资助机构 | National Basic Research Program(2015CB553501) ; National Natural Science Foundation(31170988) ; Natural Science Foundation Major Research Plan program(91332115) ; Natural Science Foundation Youth program(31500893) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/19950 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Shen, Fang |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lin Cui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 3.Johns Hopkins Univ, Sch Med, Dept Orthoped Surg, Baltimore, MD USA |
第一作者单位 | 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Meng, Xiaolu,Shen, Fang,Li, Chunlu,et al. Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2016,145(0):1-8. |
APA | Meng, Xiaolu,Shen, Fang,Li, Chunlu,Li, Yonghui,&Wang, Xuewei.(2016).Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,145(0),1-8. |
MLA | Meng, Xiaolu,et al."Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 145.0(2016):1-8. |
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