PSYCH OpenIR  > 中国科学院心理健康重点实验室
Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin
Meng, Xiaolu1,2; Shen, Fang1; Li, Chunlu1,2; Li, Yonghui1; Wang, Xuewei3
2016-06-01
发表期刊PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
文章类型Article
卷号145期号:0页码:1-8
摘要Tree shrews, a species phylogenetically close to primates, are regarded as a suitable and naturalistic animal model for depression studies. However, psychological symptoms that are essential for depression diagnosis and treatment, such as helplessness and social withdrawal, have not been studied in this model. Therefore, in this study, we first investigated learned helplessness, social interaction and sucrose preference induced by two chronic stress paradigms: uncontrollable foot shocks (1-week foot shocks) and multiple unpredictable stimuli (1-week foot shocks and 3-week unpredictable stressors) in tree shrews. Our results showed that uncontrollable foot shocks could only induce learned helplessness in animals; whereas animals treated with multiple unpredictable stimuli exhibited more depression-like behaviors including social withdrawal, anhedonia and learned helplessness. These findings suggested that multiple unpredictable stimuli could effectively induce various depression-like behaviors in tree shrews. More importantly, we compared the antidepressant effects of fluoxetine and carbetocin, a long-acting oxytocin analog, on specific depression-like behaviors. Our present data displayed that, compared with fluoxetine, carbetocin was also effective in reversing learned helplessness, elevating sucrose preference and improving social interaction behaviors in depression-like animals. Therefore, carbetocin might be a potential antidepressant with applications in humans. (C) 2016 Elsevier Inc. All rights reserved.
关键词Depression-like Behaviors Tree Shrews Uncontrollable Foot Shocks Chronic Unpredictable Stress Carbetocin
DOI10.1016/j.pbb.2016.03.006
收录类别SCI
语种英语
项目资助者National Basic Research Program(2015CB553501) ; National Natural Science Foundation(31170988) ; Natural Science Foundation Major Research Plan program(91332115) ; Natural Science Foundation Youth program(31500893) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS类目Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
WOS记录号WOS:000377326300001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]CHRONIC PSYCHOSOCIAL STRESS ; LEARNED HELPLESSNESS ; TUPAIA-BELANGERI ; MAJOR DEPRESSION ; SEXUAL-BEHAVIOR ; BRAIN OXYTOCIN ; MALE-RATS ; ANTIDEPRESSANT ; SYSTEM ; VASOPRESSIN
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19950
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lin Cui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
3.Johns Hopkins Univ, Sch Med, Dept Orthoped Surg, Baltimore, MD USA
推荐引用方式
GB/T 7714
Meng, Xiaolu,Shen, Fang,Li, Chunlu,et al. Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2016,145(0):1-8.
APA Meng, Xiaolu,Shen, Fang,Li, Chunlu,Li, Yonghui,&Wang, Xuewei.(2016).Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,145(0),1-8.
MLA Meng, Xiaolu,et al."Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 145.0(2016):1-8.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Depression-like beha(569KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Meng, Xiaolu]的文章
[Shen, Fang]的文章
[Li, Chunlu]的文章
百度学术
百度学术中相似的文章
[Meng, Xiaolu]的文章
[Shen, Fang]的文章
[Li, Chunlu]的文章
必应学术
必应学术中相似的文章
[Meng, Xiaolu]的文章
[Shen, Fang]的文章
[Li, Chunlu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。