PSYCH OpenIR  > 中国科学院行为科学重点实验室
Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain
Yang, Zhi1,2,3; Zuo, Xi-Nian1,2; McMahon, Katie L.4; Craddock, R. Cameron5,6; Kelly, Clare7; de Zubicaray, Greig I.8; Hickie, Ian9; Bandettini, Peter A.3; Castellanos, F. Xavier7; Milham, Michael P.5,6; Wright, Margaret J.10
2016-05-01
发表期刊CEREBRAL CORTEX
ISSN1047-3211
文章类型Article
卷号26期号:5页码:2341-2352
摘要One of the grand challenges faced by neuroscience is to delineate the determinants of interindividual variation in the comprehensive structural and functional connection matrices that comprise the human connectome. At present, this endeavor appears most tractable at the macroanatomic scale, where intrinsic brain activity exhibits robust patterns of synchrony that recapitulate core functional circuits at the individual level. Here, we use a classical twin study design to examine the heritability of intrinsic functional network properties in 101 twin pairs, including network activity (i.e., variance of a network's specific temporal fluctuations) and internetwork coherence (i.e., correlation between networks' specific temporal fluctuations). Five of 7 networks exhibited significantly heritable (23.3-65.2%) network activity, 6 of the 21 internetwork coherences were significantly heritable (25.6-42.0%), and 11 of the 21 internetwork coherences were significantly influenced by common environmental factors (18.0-47.1%). These results suggest that the source of interindividual variation in functional connectome has a modular architecture: individual modules represented by intrinsic connectivity networks are genetic controlled, while environmental factors influence the interplays between the modules. This work further provides network-specific hypotheses for discovery of the specific genetic and environmental factors influencing functional specialization and integration of the human brain.
关键词Connectome Environmental Contribution Heritability Intrinsic Connectivity Network Twins
DOI10.1093/cercor/bhw027
收录类别SCI ; SSCI
语种英语
项目资助者National Basic Research (973) Program(2015CB351702) ; Natural Science Foundation of China(81270023 ; Beijing Nova Program for Science and Technology(XXJH2015B079) ; Outstanding Young Investigator Award of Institute of Psychology, Chinese Academy of Sciences ; Foundation of Beijing Key Laboratory of Mental Disorders(2014JSJB03) ; Chinese Academy of Sciences(KSZD-EW-TZ-002) ; NIH(U01MH099059 ; NIMH BRAINS(R01MH094639-01) ; Chinese Academy of Sciences K.C. Wong Education Foundation ; National Basic Research (973) Program of China ; 81571756 ; R01MH083246 ; 81278412 ; R01HD050735) ; 81171409 ; 81000583 ; 81471740 ; 81220108014)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000377469500040
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]HUMAN CEREBRAL-CORTEX ; RESTING-STATE FMRI ; INDEPENDENT COMPONENT ANALYSIS ; SURFACE-BASED ANALYSIS ; DEFAULT MODE NETWORK ; WORKING-MEMORY ; LIFE-SPAN ; PREFRONTAL CORTEX ; GEOMETRICALLY ACCURATE ; MRI
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19952
专题中国科学院行为科学重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, MRI Res Ctr, Beijing 100101, Peoples R China
3.NIMH, Sect Funct Imaging Methods, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA
4.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia
5.Child Mind Inst, New York, NY USA
6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
7.NYU, Ctr Child Study, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY USA
8.Univ Queensland, Sch Psychol, Brisbane, Qld, Australia
9.Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia
10.Queensland Inst Med Res, Genet Epidemiol Lab, Brisbane, Qld 4006, Australia
推荐引用方式
GB/T 7714
Yang, Zhi,Zuo, Xi-Nian,McMahon, Katie L.,et al. Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain[J]. CEREBRAL CORTEX,2016,26(5):2341-2352.
APA Yang, Zhi.,Zuo, Xi-Nian.,McMahon, Katie L..,Craddock, R. Cameron.,Kelly, Clare.,...&Wright, Margaret J..(2016).Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain.CEREBRAL CORTEX,26(5),2341-2352.
MLA Yang, Zhi,et al."Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain".CEREBRAL CORTEX 26.5(2016):2341-2352.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Yang2016_CC.pdf(538KB)期刊论文作者接受稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Zhi]的文章
[Zuo, Xi-Nian]的文章
[McMahon, Katie L.]的文章
百度学术
百度学术中相似的文章
[Yang, Zhi]的文章
[Zuo, Xi-Nian]的文章
[McMahon, Katie L.]的文章
必应学术
必应学术中相似的文章
[Yang, Zhi]的文章
[Zuo, Xi-Nian]的文章
[McMahon, Katie L.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Yang2016_CC.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。