Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain

doi:10.1093/cercor/bhw027

	Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain
	Yang, Zhi1,2,3 ; Zuo, Xi-Nian1,2 ; McMahon, Katie L.4; Craddock, R. Cameron 5,6; Kelly, Clare 7; de Zubicaray, Greig I.8; Hickie, Ian 9; Bandettini, Peter A.3; Castellanos, F. Xavier 7; Milham, Michael P.5,6; Wright, Margaret J.10
摘要	One of the grand challenges faced by neuroscience is to delineate the determinants of interindividual variation in the comprehensive structural and functional connection matrices that comprise the human connectome. At present, this endeavor appears most tractable at the macroanatomic scale, where intrinsic brain activity exhibits robust patterns of synchrony that recapitulate core functional circuits at the individual level. Here, we use a classical twin study design to examine the heritability of intrinsic functional network properties in 101 twin pairs, including network activity (i.e., variance of a network's specific temporal fluctuations) and internetwork coherence (i.e., correlation between networks' specific temporal fluctuations). Five of 7 networks exhibited significantly heritable (23.3-65.2%) network activity, 6 of the 21 internetwork coherences were significantly heritable (25.6-42.0%), and 11 of the 21 internetwork coherences were significantly influenced by common environmental factors (18.0-47.1%). These results suggest that the source of interindividual variation in functional connectome has a modular architecture: individual modules represented by intrinsic connectivity networks are genetic controlled, while environmental factors influence the interplays between the modules. This work further provides network-specific hypotheses for discovery of the specific genetic and environmental factors influencing functional specialization and integration of the human brain.
关键词	Connectome Environmental Contribution Heritability Intrinsic Connectivity Network Twins
	2016-05-01
语种	英语
DOI	10.1093/cercor/bhw027
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
卷号	26 期号:5 页码:2341-2352
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	HUMAN CEREBRAL-CORTEX ; RESTING-STATE FMRI ; INDEPENDENT COMPONENT ANALYSIS ; SURFACE-BASED ANALYSIS ; DEFAULT MODE NETWORK ; WORKING-MEMORY ; LIFE-SPAN ; PREFRONTAL CORTEX ; GEOMETRICALLY ACCURATE ; MRI
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000377469500040
资助机构	National Basic Research (973) Program(2015CB351702) ; Natural Science Foundation of China(81270023 ; Beijing Nova Program for Science and Technology(XXJH2015B079) ; Outstanding Young Investigator Award of Institute of Psychology, Chinese Academy of Sciences ; Foundation of Beijing Key Laboratory of Mental Disorders(2014JSJB03) ; Chinese Academy of Sciences(KSZD-EW-TZ-002) ; NIH(U01MH099059 ; NIMH BRAINS(R01MH094639-01) ; Chinese Academy of Sciences K.C. Wong Education Foundation ; National Basic Research (973) Program of China ; 81571756 ; R01MH083246 ; 81278412 ; R01HD050735) ; 81171409 ; 81000583 ; 81471740 ; 81220108014)
引用统计	被引频次：71[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19952
专题	中国科学院行为科学重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, MRI Res Ctr, Beijing 100101, Peoples R China 3.NIMH, Sect Funct Imaging Methods, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA 4.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia 5.Child Mind Inst, New York, NY USA 6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA 7.NYU, Ctr Child Study, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY USA 8.Univ Queensland, Sch Psychol, Brisbane, Qld, Australia 9.Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia 10.Queensland Inst Med Res, Genet Epidemiol Lab, Brisbane, Qld 4006, Australia
第一作者单位	中国科学院行为科学重点实验室
推荐引用方式 GB/T 7714	Yang, Zhi,Zuo, Xi-Nian,McMahon, Katie L.,et al. Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain[J]. CEREBRAL CORTEX,2016,26(5):2341-2352.
APA	Yang, Zhi.,Zuo, Xi-Nian.,McMahon, Katie L..,Craddock, R. Cameron.,Kelly, Clare.,...&Wright, Margaret J..(2016).Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain.CEREBRAL CORTEX,26(5),2341-2352.
MLA	Yang, Zhi,et al."Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain".CEREBRAL CORTEX 26.5(2016):2341-2352.

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