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Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats
Zhang, Jian-Jun1,2,3; Liu, Xiao-Dong2,3; Yu, Long-Chuan2,3
第一作者Zhang, Jian-Jun
2016
发表期刊PHYSIOLOGICAL RESEARCH
ISSN0862-8408
文章类型Article
卷号65期号:1页码:165-169
Q分类Q3
产权排序1
摘要

Acute morphine exposure induces antinociceptive activity, but the underlying mechanisms in the central nervous system are unclear. Using whole-cell patch clamp recordings, we explore the role of morphine in the modulation of excitatory synaptic transmission in lateral amygdala neurons of rats. The results demonstrate that perfusion of 10 mu M of morphine to the lateral amygdala inhibits the discharge frequency significantly. We further find that there are no significant influences of morphine on the amplitude of spontaneous excitatory postsynaptic currents (sEPSCs). Interestingly, morphine shows no marked influence on the evoked excitatory postsynaptic currents (eEPSCs) in the lateral amygdala neurons. These results indicate that acute morphine treatment plays an important role in the modulation on the excitatory synaptic transmission in lateral amygdala neurons of rats.

关键词Discharge frequency Excitatory synaptic transmission Evoked excitatory postsynaptic currents (eEPSCs) Lateral amygdala Morphine Spontaneous excitatory postsynaptic currents (sEPSCs)
收录类别SCI
语种英语
项目资助者National Natural Science Research Foundation of China (NSFC)(30711120564 ; National Program of Basic Research - Ministry of Science and Technology of China(2009CB522002) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZG02) ; 31400880)
WOS研究方向Physiology
WOS类目Physiology
WOS记录号WOS:000377529800017
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]TAIL-FLICK REFLEX ; CENTRAL NUCLEUS ; BASOLATERAL AMYGDALA ; RECEPTOR SUBUNIT ; CORTEX ; ANTINOCICEPTION ; MICROINJECTION ; CONTRIBUTES ; INHIBITION ; WITHDRAWAL
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19953
专题中国科学院心理健康重点实验室
通讯作者Yu, Long-Chuan
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
3.Peking Univ, Neurobiol Lab, Coll Life Sci, Beijing 100871, Peoples R China
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Zhang, Jian-Jun,Liu, Xiao-Dong,Yu, Long-Chuan. Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats[J]. PHYSIOLOGICAL RESEARCH,2016,65(1):165-169.
APA Zhang, Jian-Jun,Liu, Xiao-Dong,&Yu, Long-Chuan.(2016).Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats.PHYSIOLOGICAL RESEARCH,65(1),165-169.
MLA Zhang, Jian-Jun,et al."Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats".PHYSIOLOGICAL RESEARCH 65.1(2016):165-169.
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