PSYCH OpenIR  > 中国科学院心理健康重点实验室
Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats
Zhang, Jian-Jun1,2,3; Liu, Xiao-Dong2,3; Yu, Long-Chuan2,3
First AuthorZhang, Jian-Jun
2016
Source PublicationPHYSIOLOGICAL RESEARCH
ISSN0862-8408
SubtypeArticle
Volume65Issue:1Pages:165-169
QuartileQ3
Contribution Rank1
Abstract

Acute morphine exposure induces antinociceptive activity, but the underlying mechanisms in the central nervous system are unclear. Using whole-cell patch clamp recordings, we explore the role of morphine in the modulation of excitatory synaptic transmission in lateral amygdala neurons of rats. The results demonstrate that perfusion of 10 mu M of morphine to the lateral amygdala inhibits the discharge frequency significantly. We further find that there are no significant influences of morphine on the amplitude of spontaneous excitatory postsynaptic currents (sEPSCs). Interestingly, morphine shows no marked influence on the evoked excitatory postsynaptic currents (eEPSCs) in the lateral amygdala neurons. These results indicate that acute morphine treatment plays an important role in the modulation on the excitatory synaptic transmission in lateral amygdala neurons of rats.

KeywordDischarge frequency Excitatory synaptic transmission Evoked excitatory postsynaptic currents (eEPSCs) Lateral amygdala Morphine Spontaneous excitatory postsynaptic currents (sEPSCs)
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Research Foundation of China (NSFC)(30711120564 ; National Program of Basic Research - Ministry of Science and Technology of China(2009CB522002) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZG02) ; 31400880)
WOS Research AreaPhysiology
WOS SubjectPhysiology
WOS IDWOS:000377529800017
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordTAIL-FLICK REFLEX ; CENTRAL NUCLEUS ; BASOLATERAL AMYGDALA ; RECEPTOR SUBUNIT ; CORTEX ; ANTINOCICEPTION ; MICROINJECTION ; CONTRIBUTES ; INHIBITION ; WITHDRAWAL
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19953
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Long-Chuan
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
3.Peking Univ, Neurobiol Lab, Coll Life Sci, Beijing 100871, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Jian-Jun,Liu, Xiao-Dong,Yu, Long-Chuan. Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats[J]. PHYSIOLOGICAL RESEARCH,2016,65(1):165-169.
APA Zhang, Jian-Jun,Liu, Xiao-Dong,&Yu, Long-Chuan.(2016).Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats.PHYSIOLOGICAL RESEARCH,65(1),165-169.
MLA Zhang, Jian-Jun,et al."Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats".PHYSIOLOGICAL RESEARCH 65.1(2016):165-169.
Files in This Item:
File Name/Size DocType Version Access License
Influences of Morphi(510KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Jian-Jun]'s Articles
[Liu, Xiao-Dong]'s Articles
[Yu, Long-Chuan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Jian-Jun]'s Articles
[Liu, Xiao-Dong]'s Articles
[Yu, Long-Chuan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Jian-Jun]'s Articles
[Liu, Xiao-Dong]'s Articles
[Yu, Long-Chuan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.