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Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells
Mo, Wei-Chuan1,2; Zhang, Zi-Jian1,3; Wang, Dong-Liang1; Liu, Ying1; Bartlett, Perry F.2; He, Rong-Qiao1,4,5
2016-03-31
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
SubtypeArticle
Volume6Issue:0Pages:1-15
AbstractAccumulating evidence has shown that absence of the geomagnetic field (GMF), the so-called hypomagnetic field (HMF) environment, alters the biological functions in seemingly nonmagnetosensitive cells and organisms, which indicates that the GMF could be sensed by non-ironrich and non-photo-sensing cells. The underlying mechanisms of the HMF effects on those cells are closely related to their GMF sensation but remain poorly understood so far. Previously, we found that the HMF represses expressions of genes associated with cell migration and cytoskeleton assembly in human neuroblastoma cells (SH-SY5Y cell line). Here, we measured the HMF-induced changes on cell morphology, adhesion, motility and actin cytoskeleton in SH-SY5Y cells. The HMF inhibited cell adhesion and migration accompanied with a reduction in cellular F-actin amount. Moreover, following exposure to the HMF, the number of cell processes was reduced and cells were smaller in size and more round in shape. Furthermore, disordered kinetics of actin assembly in vitro were observed during exposure to the HMF, as evidenced by the presence of granule and meshed products. These results indicate that elimination of the GMF affects assembly of the motility-related actin cytoskeleton, and suggest that F-actin is a target of HMF exposure and probably a mediator of GMF sensation.
DOI10.1038/srep22624
Indexed BySCI
Language英语
Funding OrganizationExternal Cooperation Program of BIC, Chinese Academy of Sciences (CAS)(GJHZ201302) ; National Nature Science Foundation of China(31200628) ; project of CAS(YZ201148) ; Queensland-CAS Biotechnology Fund(GJHZ1131)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000373069500001
WOS HeadingsScience & Technology
WOS KeywordZERO MAGNETIC-FIELD ; HYPOMAGNETIC FIELD ; F-ACTIN ; HYPOGEOMAGNETIC FIELD ; IN-VITRO ; ADHESION ; MIGRATION ; GROWTH ; MICE ; MAGNETORECEPTION
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19956
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
3.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 10069, Peoples R China
Recommended Citation
GB/T 7714
Mo, Wei-Chuan,Zhang, Zi-Jian,Wang, Dong-Liang,et al. Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells[J]. SCIENTIFIC REPORTS,2016,6(0):1-15.
APA Mo, Wei-Chuan,Zhang, Zi-Jian,Wang, Dong-Liang,Liu, Ying,Bartlett, Perry F.,&He, Rong-Qiao.(2016).Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells.SCIENTIFIC REPORTS,6(0),1-15.
MLA Mo, Wei-Chuan,et al."Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells".SCIENTIFIC REPORTS 6.0(2016):1-15.
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