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Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives
Chan, Raymond C. K.1; Huang, Jia1; Zhao, Qing2,3; Wang, Ya1; Lai, Yun-yao4; Hong, Nan4; Shum, David H. K.2,3,5,6; Cheung, Eric F. C.7; Yu, Xin8,9,10; Dazzan, Paola11,12
2015
发表期刊NEUROIMAGE-CLINICAL
ISSN2213-1582
文章类型Article
卷号9期号:0页码:411-417
摘要Neurological soft signs have been considered one of the promising neurological endophenotypes for schizophrenia. However, most previous studies have employed clinical rating data only. The present study aimed to examine the neurobiological basis of one of the typical motor coordination signs, the Fist-Edge-Palm (FEP) task, in patients with first-episode schizophrenia and their non-psychotic first degree relatives. Thirteen patients with first-episode schizophrenia, 14 non-psychotic first-degree relatives and 14 healthy controls were recruited. All of themwere instructed to performthe FEP task in a 3 T GEMachine. Psychophysiological interaction (PPI) analysiswas used to evaluate the functional connectivity between the sensorimotor cortex and frontal regionswhen participants performed the FEP task compared to simplemotor tasks. In the contrast of palm-tapping (PT) vs. rest, activation of the left frontal-parietal region was lowest in the schizophrenia group, intermediate in the relative group and highest in the healthy control group. In the contrast of FEP vs. PT, patients with schizophrenia did not show areas of significant activation, while relatives and healthy controls showed significant activation of the left middle frontal gyrus. Moreover, with the increase in task complexity, significant functional connectivity was observed between the sensorimotor cortex and the right frontal gyrus in healthy controls but not in patients with first episode schizophrenia. These findings suggest that activity of the left frontal-parietal and frontal regions may be neurofunctional correlates of neurological soft signs, which in turn may be a potential endophenotype of schizophrenia. Moreover, the right frontal gyrus may play a specific role in the execution of the FEP task in schizophrenia spectrum disorders. (C) 2015 The Authors. Published by Elsevier Inc.
关键词Neurological Soft Sign First Episode Schizophrenia First Degree Relatives Endophenotype
DOI10.1016/j.nicl.2015.09.008
收录类别SCI ; SSCI
语种英语
项目资助者Outstanding Young Investigator Award of the National Science Fund China(81088001) ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Program for Creative Research Teams(Y2CX131003) ; National Science Fund China(31100747)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000373188400044
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]NEUROLOGICAL SOFT SIGNS ; SENSORIMOTOR CORTEX ; PSYCHOTIC SYMPTOMS ; BRAIN ACTIVATION ; WORKING-MEMORY ; HIGH-RISK ; MOTOR ; METAANALYSIS ; MORPHOLOGY ; SIBLINGS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19962
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia
3.Griffith Univ, Behav Basis Hlth Program, Griffith Hlth Inst, Brisbane, Qld 4111, Australia
4.Peking Univ, Peoples Hosp, Radiol Dept, Beijing, Peoples R China
5.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia
6.Griffith Univ, Sch Appl Psychol, Gold Coast, Australia
7.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
8.Peking Univ, Hosp 6, Beijing 100871, Peoples R China
9.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
10.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
11.Kings Coll London, Inst Psychiat, London WC2R 2LS, England
12.Kings Coll London, South London & Maudsley NHS Fdn Trust, Mental Hlth Biomed Res Ctr, NIHR, London WC2R 2LS, England
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Chan, Raymond C. K.,Huang, Jia,Zhao, Qing,et al. Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives[J]. NEUROIMAGE-CLINICAL,2015,9(0):411-417.
APA Chan, Raymond C. K..,Huang, Jia.,Zhao, Qing.,Wang, Ya.,Lai, Yun-yao.,...&Dazzan, Paola.(2015).Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives.NEUROIMAGE-CLINICAL,9(0),411-417.
MLA Chan, Raymond C. K.,et al."Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives".NEUROIMAGE-CLINICAL 9.0(2015):411-417.
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