Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives

doi:10.1016/j.nicl.2015.09.008

	Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives
	Chan, Raymond C. K.1 ; Huang, Jia1 ; Zhao, Qing2,3 ; Wang, Ya1 ; Lai, Yun-yao 4; Hong, Nan 4; Shum, David H. K.2,3,5,6; Cheung, Eric F. C.7; Yu, Xin 8,9,10; Dazzan, Paola 11,12
摘要	Neurological soft signs have been considered one of the promising neurological endophenotypes for schizophrenia. However, most previous studies have employed clinical rating data only. The present study aimed to examine the neurobiological basis of one of the typical motor coordination signs, the Fist-Edge-Palm (FEP) task, in patients with first-episode schizophrenia and their non-psychotic first degree relatives. Thirteen patients with first-episode schizophrenia, 14 non-psychotic first-degree relatives and 14 healthy controls were recruited. All of themwere instructed to performthe FEP task in a 3 T GEMachine. Psychophysiological interaction (PPI) analysiswas used to evaluate the functional connectivity between the sensorimotor cortex and frontal regionswhen participants performed the FEP task compared to simplemotor tasks. In the contrast of palm-tapping (PT) vs. rest, activation of the left frontal-parietal region was lowest in the schizophrenia group, intermediate in the relative group and highest in the healthy control group. In the contrast of FEP vs. PT, patients with schizophrenia did not show areas of significant activation, while relatives and healthy controls showed significant activation of the left middle frontal gyrus. Moreover, with the increase in task complexity, significant functional connectivity was observed between the sensorimotor cortex and the right frontal gyrus in healthy controls but not in patients with first episode schizophrenia. These findings suggest that activity of the left frontal-parietal and frontal regions may be neurofunctional correlates of neurological soft signs, which in turn may be a potential endophenotype of schizophrenia. Moreover, the right frontal gyrus may play a specific role in the execution of the FEP task in schizophrenia spectrum disorders. (C) 2015 The Authors. Published by Elsevier Inc.
关键词	Neurological Soft Sign First Episode Schizophrenia First Degree Relatives Endophenotype
	2015
语种	英语
DOI	10.1016/j.nicl.2015.09.008
发表期刊	NEUROIMAGE-CLINICAL
ISSN	2213-1582
卷号	9 期号:0 页码:411-417
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	NEUROLOGICAL SOFT SIGNS ; SENSORIMOTOR CORTEX ; PSYCHOTIC SYMPTOMS ; BRAIN ACTIVATION ; WORKING-MEMORY ; HIGH-RISK ; MOTOR ; METAANALYSIS ; MORPHOLOGY ; SIBLINGS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000373188400044
资助机构	Outstanding Young Investigator Award of the National Science Fund China(81088001) ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Program for Creative Research Teams(Y2CX131003) ; National Science Fund China(31100747)
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19962
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia 3.Griffith Univ, Behav Basis Hlth Program, Griffith Hlth Inst, Brisbane, Qld 4111, Australia 4.Peking Univ, Peoples Hosp, Radiol Dept, Beijing, Peoples R China 5.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia 6.Griffith Univ, Sch Appl Psychol, Gold Coast, Australia 7.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 8.Peking Univ, Hosp 6, Beijing 100871, Peoples R China 9.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 10.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China 11.Kings Coll London, Inst Psychiat, London WC2R 2LS, England 12.Kings Coll London, South London & Maudsley NHS Fdn Trust, Mental Hlth Biomed Res Ctr, NIHR, London WC2R 2LS, England
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Chan, Raymond C. K.,Huang, Jia,Zhao, Qing,et al. Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives[J]. NEUROIMAGE-CLINICAL,2015,9(0):411-417.
APA	Chan, Raymond C. K..,Huang, Jia.,Zhao, Qing.,Wang, Ya.,Lai, Yun-yao.,...&Dazzan, Paola.(2015).Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives.NEUROIMAGE-CLINICAL,9(0),411-417.
MLA	Chan, Raymond C. K.,et al."Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives".NEUROIMAGE-CLINICAL 9.0(2015):411-417.

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