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Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives
Chan, Raymond C. K.1; Huang, Jia1; Zhao, Qing2,3; Wang, Ya1; Lai, Yun-yao4; Hong, Nan4; Shum, David H. K.2,3,5,6; Cheung, Eric F. C.7; Yu, Xin8,9,10; Dazzan, Paola11,12
2015
Source PublicationNEUROIMAGE-CLINICAL
ISSN2213-1582
SubtypeArticle
Volume9Issue:0Pages:411-417
AbstractNeurological soft signs have been considered one of the promising neurological endophenotypes for schizophrenia. However, most previous studies have employed clinical rating data only. The present study aimed to examine the neurobiological basis of one of the typical motor coordination signs, the Fist-Edge-Palm (FEP) task, in patients with first-episode schizophrenia and their non-psychotic first degree relatives. Thirteen patients with first-episode schizophrenia, 14 non-psychotic first-degree relatives and 14 healthy controls were recruited. All of themwere instructed to performthe FEP task in a 3 T GEMachine. Psychophysiological interaction (PPI) analysiswas used to evaluate the functional connectivity between the sensorimotor cortex and frontal regionswhen participants performed the FEP task compared to simplemotor tasks. In the contrast of palm-tapping (PT) vs. rest, activation of the left frontal-parietal region was lowest in the schizophrenia group, intermediate in the relative group and highest in the healthy control group. In the contrast of FEP vs. PT, patients with schizophrenia did not show areas of significant activation, while relatives and healthy controls showed significant activation of the left middle frontal gyrus. Moreover, with the increase in task complexity, significant functional connectivity was observed between the sensorimotor cortex and the right frontal gyrus in healthy controls but not in patients with first episode schizophrenia. These findings suggest that activity of the left frontal-parietal and frontal regions may be neurofunctional correlates of neurological soft signs, which in turn may be a potential endophenotype of schizophrenia. Moreover, the right frontal gyrus may play a specific role in the execution of the FEP task in schizophrenia spectrum disorders. (C) 2015 The Authors. Published by Elsevier Inc.
KeywordNeurological Soft Sign First Episode Schizophrenia First Degree Relatives Endophenotype
DOI10.1016/j.nicl.2015.09.008
Indexed BySCI ; SSCI
Language英语
Funding OrganizationOutstanding Young Investigator Award of the National Science Fund China(81088001) ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Program for Creative Research Teams(Y2CX131003) ; National Science Fund China(31100747)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000373188400044
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordNEUROLOGICAL SOFT SIGNS ; SENSORIMOTOR CORTEX ; PSYCHOTIC SYMPTOMS ; BRAIN ACTIVATION ; WORKING-MEMORY ; HIGH-RISK ; MOTOR ; METAANALYSIS ; MORPHOLOGY ; SIBLINGS
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19962
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia
3.Griffith Univ, Behav Basis Hlth Program, Griffith Hlth Inst, Brisbane, Qld 4111, Australia
4.Peking Univ, Peoples Hosp, Radiol Dept, Beijing, Peoples R China
5.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia
6.Griffith Univ, Sch Appl Psychol, Gold Coast, Australia
7.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
8.Peking Univ, Hosp 6, Beijing 100871, Peoples R China
9.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
10.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
11.Kings Coll London, Inst Psychiat, London WC2R 2LS, England
12.Kings Coll London, South London & Maudsley NHS Fdn Trust, Mental Hlth Biomed Res Ctr, NIHR, London WC2R 2LS, England
Recommended Citation
GB/T 7714
Chan, Raymond C. K.,Huang, Jia,Zhao, Qing,et al. Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives[J]. NEUROIMAGE-CLINICAL,2015,9(0):411-417.
APA Chan, Raymond C. K..,Huang, Jia.,Zhao, Qing.,Wang, Ya.,Lai, Yun-yao.,...&Dazzan, Paola.(2015).Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives.NEUROIMAGE-CLINICAL,9(0),411-417.
MLA Chan, Raymond C. K.,et al."Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives".NEUROIMAGE-CLINICAL 9.0(2015):411-417.
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