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GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats
Lin, Xiao-Jing1,2,4; Zhang, Jian-Jun1,2,3; Yu, Long-Chuan1,2
First AuthorLin, Xiao-Jing ; Zhang Jianjun
2016-04-01
Source PublicationNEUROSCIENCE BULLETIN
ISSN1673-7067
SubtypeArticle
Volume32Issue:2Pages:177-182
QuartileQ3
Contribution Rank3
Abstract

Accumulating evidence indicates that alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) are involved in the relapse to abused drugs. However, the role of AMPARs containing the GluR2 subunit in opiate addiction is still unclear. GluR2-3Y, an interfering peptide, prevents the endocytosis of AMPARs containing the GluR2 subunit. In this study, we explored the effect of intravenous injection of GluR2-3Y on the acquisition, expression, and reinstatement of morphine-induced conditioned place preference (mCPP) in rats. We found that infusion of GluR2-3Y (1.5 nmol/g) one hour before morphine during the conditioning phase inhibited the acquisition of mCPP, while an identical injection one hour before the post-conditioning test had no influence on the expression of mCPP. Injection of GluR2-3Y (1.5 nmol/g) after mCPP extinction blocked the morphine-induced reinstatement of mCPP. Our results strongly support the hypothesis that inhibition of AMPAR endocytosis provides a new target for the treatment of opiate addiction.

KeywordGluR2-3Y AMPA receptors Morphine Conditioned place preference Acquisition of mCPP Reinstatement of mCPP
DOI10.1007/s12264-016-0018-9
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81171043 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, China(KLMH2014ZG02) ; 31400880)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000373642800007
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordAMPA RECEPTOR ENDOCYTOSIS ; VENTRAL TEGMENTAL AREA ; LONG-TERM DEPRESSION ; BEHAVIORAL SENSITIZATION ; NUCLEUS-ACCUMBENS ; PREFRONTAL CORTEX ; EXPRESSION ; EXTINCTION ; ANTAGONIST ; LY293558
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19963
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Long-Chuan
Affiliation1.Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China
2.Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Natl Inst Biol Sci, Beijing 102206, Peoples R China
Recommended Citation
GB/T 7714
Lin, Xiao-Jing,Zhang, Jian-Jun,Yu, Long-Chuan. GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats[J]. NEUROSCIENCE BULLETIN,2016,32(2):177-182.
APA Lin, Xiao-Jing,Zhang, Jian-Jun,&Yu, Long-Chuan.(2016).GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats.NEUROSCIENCE BULLETIN,32(2),177-182.
MLA Lin, Xiao-Jing,et al."GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats".NEUROSCIENCE BULLETIN 32.2(2016):177-182.
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