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Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats
Lu, Jun1; Shao, Run-Hui1; Hu, Li2; Tu, Ya1; Guo, Jian-You3
2016-04-08
Source PublicationNEUROSCIENCE LETTERS
ISSN0304-3940
SubtypeArticle
Volume618Issue:0Pages:31-38
AbstractAccumulating evidence indicates that inflammation may contribute to the pathophysiology of depression. Acupuncture in traditional Chinese medicine has been considered an effective treatment for depression. However, whether the mechanisms that underlie the antidepressant effect of acupuncture are related to its antiinflammatory properties remains unclear. In the present study, rats were exposed to chronic unpredictable mild stress (CUMS) for 28 days to induce depressive-like behavior. Body weight, sucrose preference, and locomotor activity in the open field were measured. After the behavioral tests, reverse transcription polymerase chain reaction was used to determine the mRNA expression of proinflammatory cytokines (interleukin-1 beta [IL-1 beta], interleukin-6 [IL-6], and tumor necrosis factor-alpha [TNF-alpha]), and enzyme-linked immunosorbent assay was used to detect cytokine concentrations. CUMS rats exhibited decrease in body weight, sucrose preference, and locomotor activity in the open field test. Chronic acupuncture and fluoxetine treatment reversed CUMS-induced depressive-like behavior. Compared with control rats, the mRNA and protein expression of IL-1 beta, IL-6, and TNF-alpha in the hippocampus and prefrontal cortex and cytokine concentrations in serum significantly increased in CUMS rats. Acupuncture and fluoxetine treatment significantly decreased the levels of proinflammatory cytokines in the hippocampus, prefrontal cortex, and serum. These results suggest that acupuncture has antidepressant-like effects, and its mechanism of action appears to involve the inhibition of proinflammatory cytokines. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
KeywordChronic Stress Depression Acupuncture Pro-inflammatory Cytokines
DOI10.1016/j.neulet.2016.02.040
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81102638 ; 81173334 ; 31170992 ; 31371038)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000374610100006
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordNECROSIS-FACTOR-ALPHA ; CHRONIC MILD STRESS ; CHRONIC UNPREDICTABLE STRESS ; PERIPHERAL IMMUNE CHALLENGE ; PROINFLAMMATORY CYTOKINES ; MAJOR DEPRESSION ; BRAIN ; EXPRESSION ; DISORDER ; INFLAMMATION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19972
Collection中国科学院心理健康重点实验室
Affiliation1.Beijing Univ Chinese Med, Coll Acupuncture Moxibust & Tui Na, Beijing 100029, Peoples R China
2.Tangshan Feng Run Hosp TCM, Tangshan 064000, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Lu, Jun,Shao, Run-Hui,Hu, Li,et al. Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats[J]. NEUROSCIENCE LETTERS,2016,618(0):31-38.
APA Lu, Jun,Shao, Run-Hui,Hu, Li,Tu, Ya,&Guo, Jian-You.(2016).Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats.NEUROSCIENCE LETTERS,618(0),31-38.
MLA Lu, Jun,et al."Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats".NEUROSCIENCE LETTERS 618.0(2016):31-38.
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