Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats

doi:10.1016/j.neulet.2016.02.040

	Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats
	Lu, Jun 1; Shao, Run-Hui 1; Hu, Li2 ; Tu, Ya 1; Guo, Jian-You3
摘要	Accumulating evidence indicates that inflammation may contribute to the pathophysiology of depression. Acupuncture in traditional Chinese medicine has been considered an effective treatment for depression. However, whether the mechanisms that underlie the antidepressant effect of acupuncture are related to its antiinflammatory properties remains unclear. In the present study, rats were exposed to chronic unpredictable mild stress (CUMS) for 28 days to induce depressive-like behavior. Body weight, sucrose preference, and locomotor activity in the open field were measured. After the behavioral tests, reverse transcription polymerase chain reaction was used to determine the mRNA expression of proinflammatory cytokines (interleukin-1 beta [IL-1 beta], interleukin-6 [IL-6], and tumor necrosis factor-alpha [TNF-alpha]), and enzyme-linked immunosorbent assay was used to detect cytokine concentrations. CUMS rats exhibited decrease in body weight, sucrose preference, and locomotor activity in the open field test. Chronic acupuncture and fluoxetine treatment reversed CUMS-induced depressive-like behavior. Compared with control rats, the mRNA and protein expression of IL-1 beta, IL-6, and TNF-alpha in the hippocampus and prefrontal cortex and cytokine concentrations in serum significantly increased in CUMS rats. Acupuncture and fluoxetine treatment significantly decreased the levels of proinflammatory cytokines in the hippocampus, prefrontal cortex, and serum. These results suggest that acupuncture has antidepressant-like effects, and its mechanism of action appears to involve the inhibition of proinflammatory cytokines. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
关键词	Chronic Stress Depression Acupuncture Pro-inflammatory Cytokines
	2016-04-08
语种	英语
DOI	10.1016/j.neulet.2016.02.040
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	618 期号:0 页码:31-38
期刊论文类型	Article
收录类别	SCI
WOS关键词	NECROSIS-FACTOR-ALPHA ; CHRONIC MILD STRESS ; CHRONIC UNPREDICTABLE STRESS ; PERIPHERAL IMMUNE CHALLENGE ; PROINFLAMMATORY CYTOKINES ; MAJOR DEPRESSION ; BRAIN ; EXPRESSION ; DISORDER ; INFLAMMATION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000374610100006
资助机构	National Natural Science Foundation of China(81102638 ; 81173334 ; 31170992 ; 31371038)
引用统计	被引频次：52[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/19972
专题	中国科学院心理健康重点实验室
作者单位	1.Beijing Univ Chinese Med, Coll Acupuncture Moxibust & Tui Na, Beijing 100029, Peoples R China 2.Tangshan Feng Run Hosp TCM, Tangshan 064000, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Lu, Jun,Shao, Run-Hui,Hu, Li,et al. Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats[J]. NEUROSCIENCE LETTERS,2016,618(0):31-38.
APA	Lu, Jun,Shao, Run-Hui,Hu, Li,Tu, Ya,&Guo, Jian-You.(2016).Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats.NEUROSCIENCE LETTERS,618(0),31-38.
MLA	Lu, Jun,et al."Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats".NEUROSCIENCE LETTERS 618.0(2016):31-38.

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