PSYCH OpenIR  > 中国科学院心理健康重点实验室
cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function
Peng, Qionglin1,2; Wang, Yijin1,2,4,5; Li, Meixia1; Yuan, Deliang1,2; Xu, Mengbo1; Li, Changqing1; Gong, Zhefeng1,6; Jiao, Renjie1; Liu, Li1,2,3
2016-04-20
发表期刊JOURNAL OF NEUROSCIENCE
ISSN0270-6474
文章类型Article
卷号36期号:16页码:4635-4646
摘要Correct pathfinding and target recognition of a developing axon are exquisitely regulated processes that require multiple guidance factors. Among these factors, the second messengers, cAMP and cGMP, are known to be involved in establishing the guidance cues for axon growth through different intracellular signaling pathways. However, whether and how cGMP-dependent protein kinase (PKG) regulates axon guidance remains poorly understood. Here, we show that the motor axons of intersegmental nerve b (ISNb) in the Drosophila embryo display targeting defects during axon development in the absence of foraging (for), a gene encoding PKG. In vivo tag expression revealed PKG to be present in the ventral nerve code at late embryonic stages, supporting its function in embryonic axon guidance. Mechanistic studies showed that the transcription factor longitudinal lacking (lola) genetically interacts with for. PKG physically associates with the LolaT isoform via the C-terminal zinc-finger-containing domain. Overexpression of PKG leads to the cytoplasmic retention of LolaT in S2 cells, suggesting a role for PKG in mediating the nucleocytoplasmic trafficking of Lola. Together, these findings reveal a novel function of PKG in regulating the establishment of neuronal connectivity by sequestering Lola in the cytoplasm.
关键词Drosophila Lola Motor Axon Guidance Pkg
DOI10.1523/JNEUROSCI.3726-15.2016
收录类别SCI
语种英语
项目资助者Strategic Priority Research Program B of the Chinese Academy of Sciences(XDB02040002) ; Ministry of Science and Technology of China(2012CB825504) ; National Natural Sciences Foundation of China(31030037 ; 31571033 ; 81470846 ; 31271573 ; 31529004)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000375130000021
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]GUANYLYL CYCLASE GYC76C ; TRANSCRIPTION FACTOR ; MELANOGASTER ; GROWTH ; RECEPTOR ; GENE ; CONNECTIVITY ; POLYMORPHISM ; EXPRESSION ; REPULSION
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19980
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA
5.Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
6.Zhejiang Univ, Sch Med, Dept Neurobiol, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714
Peng, Qionglin,Wang, Yijin,Li, Meixia,et al. cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function[J]. JOURNAL OF NEUROSCIENCE,2016,36(16):4635-4646.
APA Peng, Qionglin.,Wang, Yijin.,Li, Meixia.,Yuan, Deliang.,Xu, Mengbo.,...&Liu, Li.(2016).cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function.JOURNAL OF NEUROSCIENCE,36(16),4635-4646.
MLA Peng, Qionglin,et al."cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function".JOURNAL OF NEUROSCIENCE 36.16(2016):4635-4646.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
cGMP-Dependent Prote(4862KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Peng, Qionglin]的文章
[Wang, Yijin]的文章
[Li, Meixia]的文章
百度学术
百度学术中相似的文章
[Peng, Qionglin]的文章
[Wang, Yijin]的文章
[Li, Meixia]的文章
必应学术
必应学术中相似的文章
[Peng, Qionglin]的文章
[Wang, Yijin]的文章
[Li, Meixia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。