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A Brain Signature to Differentiate Acute and Chronic Pain in Rats
Guo, Yifei1,2; Wang, Yuzheng1,2; Sun, Yabin1,2; Wang, Jin-Yan1
2016-04-28
Source PublicationFRONTIERS IN COMPUTATIONAL NEUROSCIENCE
ISSN1662-5188
SubtypeArticle
Volume10Issue:0Pages:41
AbstractThe transition from acute pain to chronic pain entails considerable changes of patients at multiple levels of the nervous system and in psychological states. An accurate differentiation between acute and chronic pain is essential in pain management as it may help optimize analgesic treatments according to the pain state of patients. Given that acute and chronic pain could modulate brain states in different ways and that brain states could greatly shape the neural processing of external inputs, we hypothesized that acute and chronic pain would show differential effects on cortical responses to non-nociceptive sensory information. Here by analyzing auditory-evoked potentials (AEPs) to pure tones in rats with acute or chronic pain, we found opposite influences of acute and chronic pain on cortical responses to auditory inputs. In particular, compared to no-pain controls, the N100 wave of rat AEPs was significantly enhanced in rats with acute pain but significantly reduced in rats with chronic pain, indicating that acute pain facilitated cortical processing of auditory information while chronic pain exerted an inhibitory effect. These findings could be justified by the fact that individuals suffering from acute or chronic pain would have different vigilance states, i.e., the vigilance level to external sensory stimuli would be increased with acute pain, but decreased with chronic pain. Therefore, this auditory response holds promise of being a brain signature to differentiate acute and chronic pain. Instead of investigating the pain system per se, the study of pain-induced influences on cortical processing of non-nocicpetive sensory information might represent a potential strategy to monitor the progress of pain chronification in clinical applications.
KeywordAcutepain Chronic Pain Auditory-evoked Potentials (Aeps) Sensory Processing Animal Models
DOI10.3389/fncom.2016.00041
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China (NSFC)(31271092) ; Youth Innovation Promotion Association of the Chinese Academy of Sciences
WOS Research AreaMathematical & Computational Biology ; Neurosciences & Neurology
WOS SubjectMathematical & Computational Biology ; Neurosciences
WOS IDWOS:000374922300001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordEVENT-RELATED POTENTIALS ; CLINICAL-PRACTICE GUIDELINE ; AUDITORY-EVOKED-POTENTIALS ; CHRONIC BACK-PAIN ; SOCIETY/AMERICAN COLLEGE ; COGNITIVE PERFORMANCE ; INTENSITY DEPENDENCE ; CORTICAL POTENTIALS ; MISMATCH NEGATIVITY ; SLEEP-DEPRIVATION
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19982
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Sch Humanities, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Guo, Yifei,Wang, Yuzheng,Sun, Yabin,et al. A Brain Signature to Differentiate Acute and Chronic Pain in Rats[J]. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,2016,10(0):41.
APA Guo, Yifei,Wang, Yuzheng,Sun, Yabin,&Wang, Jin-Yan.(2016).A Brain Signature to Differentiate Acute and Chronic Pain in Rats.FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,10(0),41.
MLA Guo, Yifei,et al."A Brain Signature to Differentiate Acute and Chronic Pain in Rats".FRONTIERS IN COMPUTATIONAL NEUROSCIENCE 10.0(2016):41.
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