Patients with bipolar disorder show differential executive dysfunctions: A case-control study

doi:10.1016/j.psychres.2016.01.055

	Patients with bipolar disorder show differential executive dysfunctions: A case-control study
	Leung, Meranda M. W.1; Lui, Simon S. Y.1,2,3; Wang, Ya2 ; Tsui, Chi F.1; Au, Angie C. W.1; Yeung, Hera K. H.1; Yang, Tian-xiao2 ; Li, Zhi 2,3; Cheng, Chi-wai 1; Cheung, Eric F. C.1; Chan, Raymond C. K.2
摘要	Executive deficits in euthymic bipolar I disorder were examined in a fractionated manner based on the "Supervisory Attentional System" (SAS) model, and the relationship between the degree of executive impairment and the demographic and clinical characteristics of bipolar I participants was explored. A battery of neurocognitive tests capturing specific components of executive function was administered on 30 patients with bipolar I disorder in euthymic state, and compared with 30 healthy controls who were matched by age, gender and IQ. A differential impairment in executive function was demonstrated in euthymic bipolar I participants by using a fractionated approach of the SAS. Euthymic bipolar I patients were found to have significantly poorer performance in immediate and delayed visual memory; and in the executive domains of "initiation", "sustained attention", and "attention allocation and planning". Those with a greater number of executive impairments had lower IQ and higher negative sub-scores on PANSS. These findings might provide a the basis for further studies on identifying the executive components that are associated with particular disease characteristics of bipolar disorder, and those with poorer functional outcome, so that rehabilitation can be focused on the selective domains concerned. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
关键词	Fractionation Of Executive Function Bipolar i Disorder Supervisory Attention System
	2016-04-30
语种	英语
DOI	10.1016/j.psychres.2016.01.055
发表期刊	PSYCHIATRY RESEARCH
ISSN	0165-1781
卷号	238 期号:0 页码:129-136
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	I DISORDER ; EUTHYMIC PATIENTS ; NEUROCOGNITIVE IMPAIRMENT ; COGNITIVE IMPAIRMENT ; RATING-SCALE ; SCHIZOPHRENIA ; PERFORMANCE ; DEFICITS ; METAANALYSIS ; DEPRESSION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000375362300020
资助机构	Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19990
专题	中国科学院心理健康重点实验室
作者单位	1.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Leung, Meranda M. W.,Lui, Simon S. Y.,Wang, Ya,et al. Patients with bipolar disorder show differential executive dysfunctions: A case-control study[J]. PSYCHIATRY RESEARCH,2016,238(0):129-136.
APA	Leung, Meranda M. W..,Lui, Simon S. Y..,Wang, Ya.,Tsui, Chi F..,Au, Angie C. W..,...&Chan, Raymond C. K..(2016).Patients with bipolar disorder show differential executive dysfunctions: A case-control study.PSYCHIATRY RESEARCH,238(0),129-136.
MLA	Leung, Meranda M. W.,et al."Patients with bipolar disorder show differential executive dysfunctions: A case-control study".PSYCHIATRY RESEARCH 238.0(2016):129-136.

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