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Patients with bipolar disorder show differential executive dysfunctions: A case-control study
Leung, Meranda M. W.1; Lui, Simon S. Y.1,2,3; Wang, Ya2; Tsui, Chi F.1; Au, Angie C. W.1; Yeung, Hera K. H.1; Yang, Tian-xiao2; Li, Zhi2,3; Cheng, Chi-wai1; Cheung, Eric F. C.1; Chan, Raymond C. K.2
2016-04-30
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
SubtypeArticle
Volume238Issue:0Pages:129-136
AbstractExecutive deficits in euthymic bipolar I disorder were examined in a fractionated manner based on the "Supervisory Attentional System" (SAS) model, and the relationship between the degree of executive impairment and the demographic and clinical characteristics of bipolar I participants was explored. A battery of neurocognitive tests capturing specific components of executive function was administered on 30 patients with bipolar I disorder in euthymic state, and compared with 30 healthy controls who were matched by age, gender and IQ. A differential impairment in executive function was demonstrated in euthymic bipolar I participants by using a fractionated approach of the SAS. Euthymic bipolar I patients were found to have significantly poorer performance in immediate and delayed visual memory; and in the executive domains of "initiation", "sustained attention", and "attention allocation and planning". Those with a greater number of executive impairments had lower IQ and higher negative sub-scores on PANSS. These findings might provide a the basis for further studies on identifying the executive components that are associated with particular disease characteristics of bipolar disorder, and those with poorer functional outcome, so that rehabilitation can be focused on the selective domains concerned. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
KeywordFractionation Of Executive Function Bipolar i Disorder Supervisory Attention System
DOI10.1016/j.psychres.2016.01.055
Indexed BySCI ; SSCI
Language英语
Funding OrganizationBeijing Training Project for the Leading Talents in S T(Z151100000315020) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000375362300020
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordI DISORDER ; EUTHYMIC PATIENTS ; NEUROCOGNITIVE IMPAIRMENT ; COGNITIVE IMPAIRMENT ; RATING-SCALE ; SCHIZOPHRENIA ; PERFORMANCE ; DEFICITS ; METAANALYSIS ; DEPRESSION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19990
Collection中国科学院心理健康重点实验室
Affiliation1.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Leung, Meranda M. W.,Lui, Simon S. Y.,Wang, Ya,et al. Patients with bipolar disorder show differential executive dysfunctions: A case-control study[J]. PSYCHIATRY RESEARCH,2016,238(0):129-136.
APA Leung, Meranda M. W..,Lui, Simon S. Y..,Wang, Ya.,Tsui, Chi F..,Au, Angie C. W..,...&Chan, Raymond C. K..(2016).Patients with bipolar disorder show differential executive dysfunctions: A case-control study.PSYCHIATRY RESEARCH,238(0),129-136.
MLA Leung, Meranda M. W.,et al."Patients with bipolar disorder show differential executive dysfunctions: A case-control study".PSYCHIATRY RESEARCH 238.0(2016):129-136.
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