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| Patients with bipolar disorder show differential executive dysfunctions: A case-control study | |
Leung, Meranda M. W.1; Lui, Simon S. Y.1,2,3; Wang, Ya2 ; Tsui, Chi F.1; Au, Angie C. W.1; Yeung, Hera K. H.1; Yang, Tian-xiao2; Li, Zhi2,3; Cheng, Chi-wai1; Cheung, Eric F. C.1; Chan, Raymond C. K.2
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| 2016-04-30 | |
| Source Publication | PSYCHIATRY RESEARCH
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| ISSN | 0165-1781 |
| Subtype | Article |
| Volume | 238Issue:0Pages:129-136 |
| Abstract | Executive deficits in euthymic bipolar I disorder were examined in a fractionated manner based on the "Supervisory Attentional System" (SAS) model, and the relationship between the degree of executive impairment and the demographic and clinical characteristics of bipolar I participants was explored. A battery of neurocognitive tests capturing specific components of executive function was administered on 30 patients with bipolar I disorder in euthymic state, and compared with 30 healthy controls who were matched by age, gender and IQ. A differential impairment in executive function was demonstrated in euthymic bipolar I participants by using a fractionated approach of the SAS. Euthymic bipolar I patients were found to have significantly poorer performance in immediate and delayed visual memory; and in the executive domains of "initiation", "sustained attention", and "attention allocation and planning". Those with a greater number of executive impairments had lower IQ and higher negative sub-scores on PANSS. These findings might provide a the basis for further studies on identifying the executive components that are associated with particular disease characteristics of bipolar disorder, and those with poorer functional outcome, so that rehabilitation can be focused on the selective domains concerned. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
| Keyword | Fractionation Of Executive Function Bipolar i Disorder Supervisory Attention System |
| DOI | 10.1016/j.psychres.2016.01.055 |
| Indexed By | SCI ; SSCI |
| Language | 英语 |
| Funding Organization | Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
| WOS Research Area | Psychiatry |
| WOS Subject | Psychiatry |
| WOS ID | WOS:000375362300020 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| WOS Keyword | I DISORDER ; EUTHYMIC PATIENTS ; NEUROCOGNITIVE IMPAIRMENT ; COGNITIVE IMPAIRMENT ; RATING-SCALE ; SCHIZOPHRENIA ; PERFORMANCE ; DEFICITS ; METAANALYSIS ; DEPRESSION |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/19990 |
| Collection | 中国科学院心理健康重点实验室 |
| Affiliation | 1.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Leung, Meranda M. W.,Lui, Simon S. Y.,Wang, Ya,et al. Patients with bipolar disorder show differential executive dysfunctions: A case-control study[J]. PSYCHIATRY RESEARCH,2016,238(0):129-136. |
| APA | Leung, Meranda M. W..,Lui, Simon S. Y..,Wang, Ya.,Tsui, Chi F..,Au, Angie C. W..,...&Chan, Raymond C. K..(2016).Patients with bipolar disorder show differential executive dysfunctions: A case-control study.PSYCHIATRY RESEARCH,238(0),129-136. |
| MLA | Leung, Meranda M. W.,et al."Patients with bipolar disorder show differential executive dysfunctions: A case-control study".PSYCHIATRY RESEARCH 238.0(2016):129-136. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Patients with bipola（295KB） | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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