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The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia
Ding, Junhua1; Chen, Keliang2; Chen, Yan1; Fang, Yuxing1; Yang, Qing2; Lv, Yingru3; Lin, Nan4; Bi, Yanchao1; Guo, Qihao2; Han, Zaizhu1
2016-05-19
发表期刊FRONTIERS IN HUMAN NEUROSCIENCE
ISSN1662-5161
文章类型Article
卷号10期号:0页码:215
摘要Given that extensive cerebral regions are co-atrophic in semantic dementia (SD), it is not yet known which critical regions (SD-semantic-critical regions) are really responsible for the semantic deficits of SD. To identify the SD-semantic-critical regions, we explored the relationship between the degree of cerebral atrophy in the whole brain and the severity of semantic deficits in 19 individuals with SD. We found that the gray matter volumes (GMVs) of two regions [left fusiform gyrus (IFFG) and left parahippocampal gyrus (IPHG)] significantly correlated with the semantic scores of patients with SD. Importantly, the effects of the IFFG remained significant after controlling for the GMVs of the IPHG. Moreover, the effects of the region could not be accounted for by the total GMV, general cognitive ability, laterality of brain atrophy, or control task performance. We further observed that each atrophic portion of the IFFG along the anterior posterior axis might dedicate to the loss of semantic functions in SD. These results reveal that the IFFG could be a critical region contributing to the semantic deficits of SD.
关键词Lesion-behavior Mapping Fusiform Gyrus Co-atrophy Semantic Dementia Semantic Deficits
DOI10.3139/fnhum.2016.00215
收录类别SCI ; SSCI
语种英语
项目资助者973 Program(2013CB837300 ; National Social Science Foundation(11 ; National Natural Science Foundation of China(31271115 ; Fundamental Research Funds for the Central Universities(2014kJJCA07) ; 2014CB846100) ; ZD186) ; 81171019 ; 31171073 ; 31222024)
WOS研究方向Neurosciences & Neurology ; Psychology
WOS类目Neurosciences ; Psychology
WOS记录号WOS:000376059700001
WOS标题词Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
关键词[WOS]PRIMARY PROGRESSIVE APHASIA ; DISTORTION-CORRECTED FMRI ; ANTERIOR TEMPORAL-LOBES ; HUMAN BRAIN ; ALZHEIMERS-DISEASE ; PERIRHINAL CORTEX ; PATTERNS ; ATROPHY ; CHINESE ; REPRESENTATION
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19994
专题认知与发展心理学研究室
作者单位1.Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai 200433, Peoples R China
3.Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200433, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
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Ding, Junhua,Chen, Keliang,Chen, Yan,et al. The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2016,10(0):215.
APA Ding, Junhua.,Chen, Keliang.,Chen, Yan.,Fang, Yuxing.,Yang, Qing.,...&Han, Zaizhu.(2016).The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia.FRONTIERS IN HUMAN NEUROSCIENCE,10(0),215.
MLA Ding, Junhua,et al."The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia".FRONTIERS IN HUMAN NEUROSCIENCE 10.0(2016):215.
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