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Cortical Thickness Changes Correlate with Cognition Changes after Cognitive Training: Evidence from a Chinese Community Study
Jiang, Lijuan1,2,3; Cao, Xinyi1,2,3; Li, Ting4; Tang, Yingying1,2,3; Li, Wei1,2,3; Wang, Jijun1,2,3; Chan, Raymond C.5; Li, Chunbo1,2,3
2016-05-24
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
SubtypeArticle
Volume8Issue:0Pages:118
AbstractThe aim of this study was to investigate whether changes in cortical thickness correlated with cognitive function changes in healthy older adults after receiving cognitive training interventions. Moreover, it also aimed to examine the differential impacts of a multi-domain and a single-domain cognitive training interventions. Longitudinal magnetic resonance imaging (MRI) scanning was performed on participants 65-75 years of age using the Siemens 3.0 T Trio Tim with the Magnetization Prepared Rapid Gradient Echo (MPRAGE) sequence. The cortical thickness was determined using FreeSurfer Software. Cognitive functioning was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). There were significant group x time interaction effects on the left supramarginal, the left frontal pole cortical regions; and a marginal significant group x time interaction effects on visuospatial/constructional and delayed memory scores. In a multi domain cognitive training group, a number of cortical region changes were significantly positively correlated with changes in attention, delayed memory, and the total score, but significantly negatively correlated with changes in immediate memory and language scores. In the single-domain cognitive training group, some cortical region changes were significantly positively associated with changes in immediate memory, delayed memory, and the total score, while they were significantly negatively associated with changes in visuospatial/constructional, language, and attention scores. Overall, multi-domain cognitive training offered more advantages in visuospatial/constructional, attention, and delayed memory abilities, while single-domain cognitive training benefited immediate memory ability more effectively. These findings suggest that healthy older adults benefit more from the multi domain cognitive training than single-domain cognitive training. Cognitive training has impacted on cortical thickness changes in healthy elderly.
KeywordAging Cognitive Function Cortical Thickness Multi-domain Single-domain
DOI10.3389/fnagi.2016.00118
Indexed BySCI
Language英语
Funding OrganizationNational Nature Science Foundation of China(81371505 ; Science and Technology Commission of Shanghai Municipality(134119a2501 ; Shanghai Mental Health Center(2013-Y1-09 ; 30770769) ; 13dz2260500) ; 2014-YJ-05)
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000376478000001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordNEUROPSYCHOLOGICAL STATUS RBANS ; RANDOMIZED CONTROLLED-TRIAL ; HUMAN CEREBRAL-CORTEX ; HEALTHY OLDER-ADULTS ; REPEATABLE BATTERY ; ALZHEIMERS-DISEASE ; INTERVENTIONS ; RELIABILITY ; PERFORMANCE ; IMPAIRMENT
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19995
Collection中国科学院心理健康重点实验室
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai 200030, Peoples R China
2.Shanghai Jiao Tong Univ, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, Shanghai 200030, Peoples R China
3.Shanghai Jiao Tong Univ, Brain Sci & Technol Res Ctr, Shanghai 200030, Peoples R China
4.Shanghai Chang Ning Mental Hlth Ctr, Shanghai, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Lijuan,Cao, Xinyi,Li, Ting,et al. Cortical Thickness Changes Correlate with Cognition Changes after Cognitive Training: Evidence from a Chinese Community Study[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):118.
APA Jiang, Lijuan.,Cao, Xinyi.,Li, Ting.,Tang, Yingying.,Li, Wei.,...&Li, Chunbo.(2016).Cortical Thickness Changes Correlate with Cognition Changes after Cognitive Training: Evidence from a Chinese Community Study.FRONTIERS IN AGING NEUROSCIENCE,8(0),118.
MLA Jiang, Lijuan,et al."Cortical Thickness Changes Correlate with Cognition Changes after Cognitive Training: Evidence from a Chinese Community Study".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):118.
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