Clinical Utility and Lifespan Profiling of Neurological Soft Signs in Schizophrenia Spectrum Disorders

doi:10.1093/schbul/sbv196

	Clinical Utility and Lifespan Profiling of Neurological Soft Signs in Schizophrenia Spectrum Disorders
	Chan, Raymond C. K.1 ; Xie, Weizhen 2; Geng, Fu-lei 1,3; Wang, Ya1 ; Lui, Simon S. Y.1,3,4; Wang, Chuan-yue 5,6; Yu, Xin 7,8,9; Cheung, Eric F. C.4; Rosenthal, Robert 2
摘要	Neurological soft signs (NSSs) bear the promise for early detection of schizophrenia spectrum disorders. Nonetheless, the sensitivity and specificity of NSSs in the psychosis continuum remains a topic of controversy. It is also unknown how NSSs reveal neurodevelopmental abnormality in schizophrenia. We investigated the effect sizes of NSSs in differentiating individuals with schizophrenia spectrum disorders from individuals with other psychiatric conditions and from covariate-matched healthy subjects. We also investigated the partitioned age-related variations of NSSs in both schizophrenia and healthy individuals. NSSs were assessed by the abridged version of the Cambridge Neurological Inventory (CNI) in 3105 participants, consisting of healthy individuals (n = 1577), unaffected first-degree relatives of schizophrenia patients (n = 155), individuals with schizotypal personality disorder (n = 256), schizophrenia patients (n = 738), and other psychiatric patients (n = 379). Exact matching and propensity score matching procedures were performed to control for covariates. Multiple regression was used to partition age-related variations. Individuals along the schizophrenia continuum showed elevated levels of NSSs, with moderate effect sizes, in contrast to other psychiatric patients who had minimal NSSs, as well as matched healthy controls. Furthermore, the age-and-NSS relationship in schizophrenia patients was represented by a flat but overall elevated pattern, in contrast to a U-shaped pattern in healthy individuals. In sum, NSSs capture a moderate portion of psychosis proneness with reasonable specificity. Lifespan profiling reveals an abnormal developmental trajectory of NSSs in schizophrenia patients, which supports the endophenotype hypothesis of NSSs by associating it with the neurodevelopmental model of schizophrenia.
关键词	Neurological Soft Sign Schizophrenia Spectrum Disorders Lifespan Profiling Psychopathology Endophenotype
	2016-05-01
语种	英语
DOI	10.1093/schbul/sbv196
发表期刊	SCHIZOPHRENIA BULLETIN
ISSN	0586-7614
卷号	42 期号:3 页码:560-570
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	OBSESSIVE-COMPULSIVE DISORDER ; MINI-MENTAL-STATE ; PROPENSITY SCORE ; 1ST-EPISODE SCHIZOPHRENIA ; BRAIN-DEVELOPMENT ; MATCHING METHODS ; CAUSAL ; ENDOPHENOTYPES ; MULTIVARIATE ; METAANALYSIS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000376402000009
资助机构	National Science Fund China(81088001) ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; National Basic Research Programme (973 Programme)(2007CB512302) ; Knowledge Innovation Project of the Chinese Academy of Sciences(KSCX2-EW-J-8) ; key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams(Y2CX131003)
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19998
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 5.Capital Med Univ, Beijing Anding Hosp, Dept Psychiat, Beijing Key Lab Mental Disorders, Beijing, Peoples R China 6.Capital Med Univ, Beijing Inst Brain Disorders, Ctr Schizophrenia, Minist Sci & Technol,Lab Brain Disorders, Beijing, Peoples R China 7.Peking Univ, Hosp 6, Beijing 100871, Peoples R China 8.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 9.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Chan, Raymond C. K.,Xie, Weizhen,Geng, Fu-lei,et al. Clinical Utility and Lifespan Profiling of Neurological Soft Signs in Schizophrenia Spectrum Disorders[J]. SCHIZOPHRENIA BULLETIN,2016,42(3):560-570.
APA	Chan, Raymond C. K..,Xie, Weizhen.,Geng, Fu-lei.,Wang, Ya.,Lui, Simon S. Y..,...&Rosenthal, Robert.(2016).Clinical Utility and Lifespan Profiling of Neurological Soft Signs in Schizophrenia Spectrum Disorders.SCHIZOPHRENIA BULLETIN,42(3),560-570.
MLA	Chan, Raymond C. K.,et al."Clinical Utility and Lifespan Profiling of Neurological Soft Signs in Schizophrenia Spectrum Disorders".SCHIZOPHRENIA BULLETIN 42.3(2016):560-570.

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