Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease

doi:10.1038/npp.2016.18

	Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease
	Borchert, Robin J.1; Rittman, Timothy 1; Passamonti, Luca 1,2; Ye, Zheng3 ; Sami, Saber 1; Jones, Simon P.1; Nombela, Cristina 4; Rodriguez, Patricia Vazquez 1; Vatansever, Deniz 5; Rae, Charlotte L.6,7; Hughes, Laura E.1,8; Robbins, Trevor W.9; Rowe, James B.1,8,9
摘要	Cognitive impairment is common in Parkinson's disease (PD), but often not improved by dopaminergic treatment. New treatment strategies targeting other neurotransmitter deficits are therefore of growing interest. Imaging the brain at rest ('task-free') provides the opportunity to examine the impact of a candidate drug on many of the brain networks that underpin cognition, while minimizing task related performance confounds. We test this approach using atomoxetine, a selective noradrenaline reuptake inhibitor that modulates the prefrontal cortical activity and can facilitate some executive functions and response inhibition. Thirty-three patients with idiopathic PD underwent task-free fMRI. Patients were scanned twice in a double-blind, placebo-controlled crossover design, following either placebo or 40-mg oral atomoxetine. Seventy-six controls were scanned once without medication to provide normative data. Seed-based correlation analyses were used to measure changes in functional connectivity, with the right inferior frontal gyms (IFG) a critical region for executive function. Patients on placebo had reduced connectivity relative to controls from right IFG to dorsal anterior cingulate cortex and to left IFG and dorsolateral prefrontal cortex. Atomoxetine increased connectivity from the right IFG to the dorsal anterior cingulate. In addition, the atomoxetine-induced change in connectivity from right IFG to dorsolateral prefrontal cortex was proportional to the change in verbal fluency, a simple index of executive function. The results support the hypothesis that atomoxetine may restore prefrontal networks related to executive functions. We suggest that task-free imaging can support translational pharmacological studies of new drug therapies and provide evidence for engagement of the relevant neurocognitive systems.
	2016-07-01
语种	英语
DOI	10.1038/npp.2016.18
发表期刊	NEUROPSYCHOPHARMACOLOGY
ISSN	0893-133X
卷号	41 期号:8 页码:2171-2177
期刊论文类型	Article
收录类别	SCI
WOS关键词	ANTERIOR CINGULATE CORTEX ; RESPONSE-INHIBITION ; EXECUTIVE FUNCTION ; VERBAL FLUENCY ; FUNCTIONAL CONNECTIVITY ; EXTRACELLULAR LEVELS ; ACTIVATION ; DOPAMINE ; METHYLPHENIDATE ; NOREPINEPHRINE
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目	Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000377842800024
资助机构	Wellcome trust(103838) ; Parkinson's UK ; National Institute for Health Research's Cambridge Biomedical Research Centre ; Medical Research Council(MC-A060-5PQ30 ; James F McDonnell Foundation ; RG62761)
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20019
专题	中国科学院心理健康重点实验室
作者单位	1.Univ Cambridge, Dept Clin Neurosci, Herchel Smith Bldg,Forvie Site,Robinson Way, Cambridge CB3 0SZ, England 2.CNR, Inst Bioimaging & Mol Physiol, Catanzaro, Italy 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Tech Univ Cartagena, Syst & Automat Control Engn, Cartagena, Spain 5.Univ Cambridge, Div Anaesthesia, Herchel Smith Bldg,Forvie Site,Robinson Way, Cambridge CB3 0SZ, England 6.Univ Sussex, Sackler Ctr Consciousness Sci, Brighton, E Sussex, England 7.Brighton & Sussex Med Sch, Dept Psychiat, Brighton, E Sussex, England 8.Univ Cambridge, MRC Cognit & Brain Sci Unit, Herchel Smith Bldg,Forvie Site,Robinson Way, Cambridge CB3 0SZ, England 9.Univ Cambridge, Behav & Clin Neurosci Inst, Herchel Smith Bldg,Forvie Site,Robinson Way, Cambridge CB3 0SZ, England
推荐引用方式 GB/T 7714	Borchert, Robin J.,Rittman, Timothy,Passamonti, Luca,et al. Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease[J]. NEUROPSYCHOPHARMACOLOGY,2016,41(8):2171-2177.
APA	Borchert, Robin J..,Rittman, Timothy.,Passamonti, Luca.,Ye, Zheng.,Sami, Saber.,...&Rowe, James B..(2016).Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease.NEUROPSYCHOPHARMACOLOGY,41(8),2171-2177.
MLA	Borchert, Robin J.,et al."Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease".NEUROPSYCHOPHARMACOLOGY 41.8(2016):2171-2177.

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