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Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease
Borchert, Robin J.1; Rittman, Timothy1; Passamonti, Luca1,2; Ye, Zheng3; Sami, Saber1; Jones, Simon P.1; Nombela, Cristina4; Rodriguez, Patricia Vazquez1; Vatansever, Deniz5; Rae, Charlotte L.6,7; Hughes, Laura E.1,8; Robbins, Trevor W.9; Rowe, James B.1,8,9
2016-07-01
发表期刊NEUROPSYCHOPHARMACOLOGY
ISSN0893-133X
文章类型Article
卷号41期号:8页码:2171-2177
摘要Cognitive impairment is common in Parkinson's disease (PD), but often not improved by dopaminergic treatment. New treatment strategies targeting other neurotransmitter deficits are therefore of growing interest. Imaging the brain at rest ('task-free') provides the opportunity to examine the impact of a candidate drug on many of the brain networks that underpin cognition, while minimizing task related performance confounds. We test this approach using atomoxetine, a selective noradrenaline reuptake inhibitor that modulates the prefrontal cortical activity and can facilitate some executive functions and response inhibition. Thirty-three patients with idiopathic PD underwent task-free fMRI. Patients were scanned twice in a double-blind, placebo-controlled crossover design, following either placebo or 40-mg oral atomoxetine. Seventy-six controls were scanned once without medication to provide normative data. Seed-based correlation analyses were used to measure changes in functional connectivity, with the right inferior frontal gyms (IFG) a critical region for executive function. Patients on placebo had reduced connectivity relative to controls from right IFG to dorsal anterior cingulate cortex and to left IFG and dorsolateral prefrontal cortex. Atomoxetine increased connectivity from the right IFG to the dorsal anterior cingulate. In addition, the atomoxetine-induced change in connectivity from right IFG to dorsolateral prefrontal cortex was proportional to the change in verbal fluency, a simple index of executive function. The results support the hypothesis that atomoxetine may restore prefrontal networks related to executive functions. We suggest that task-free imaging can support translational pharmacological studies of new drug therapies and provide evidence for engagement of the relevant neurocognitive systems.
DOI10.1038/npp.2016.18
收录类别SCI
语种英语
项目资助者Wellcome trust(103838) ; Parkinson's UK ; National Institute for Health Research's Cambridge Biomedical Research Centre ; Medical Research Council(MC-A060-5PQ30 ; James F McDonnell Foundation ; RG62761)
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000377842800024
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ANTERIOR CINGULATE CORTEX ; RESPONSE-INHIBITION ; EXECUTIVE FUNCTION ; VERBAL FLUENCY ; FUNCTIONAL CONNECTIVITY ; EXTRACELLULAR LEVELS ; ACTIVATION ; DOPAMINE ; METHYLPHENIDATE ; NOREPINEPHRINE
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20019
专题中国科学院心理健康重点实验室
作者单位1.Univ Cambridge, Dept Clin Neurosci, Herchel Smith Bldg,Forvie Site,Robinson Way, Cambridge CB3 0SZ, England
2.CNR, Inst Bioimaging & Mol Physiol, Catanzaro, Italy
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Tech Univ Cartagena, Syst & Automat Control Engn, Cartagena, Spain
5.Univ Cambridge, Div Anaesthesia, Herchel Smith Bldg,Forvie Site,Robinson Way, Cambridge CB3 0SZ, England
6.Univ Sussex, Sackler Ctr Consciousness Sci, Brighton, E Sussex, England
7.Brighton & Sussex Med Sch, Dept Psychiat, Brighton, E Sussex, England
8.Univ Cambridge, MRC Cognit & Brain Sci Unit, Herchel Smith Bldg,Forvie Site,Robinson Way, Cambridge CB3 0SZ, England
9.Univ Cambridge, Behav & Clin Neurosci Inst, Herchel Smith Bldg,Forvie Site,Robinson Way, Cambridge CB3 0SZ, England
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Borchert, Robin J.,Rittman, Timothy,Passamonti, Luca,et al. Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease[J]. NEUROPSYCHOPHARMACOLOGY,2016,41(8):2171-2177.
APA Borchert, Robin J..,Rittman, Timothy.,Passamonti, Luca.,Ye, Zheng.,Sami, Saber.,...&Rowe, James B..(2016).Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease.NEUROPSYCHOPHARMACOLOGY,41(8),2171-2177.
MLA Borchert, Robin J.,et al."Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease".NEUROPSYCHOPHARMACOLOGY 41.8(2016):2171-2177.
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