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The network of causal interactions for beta oscillations in the pedunculopontine nucleus, primary motor cortex, and subthalamic nucleus of walking parkinsonian rats
Li, Min1; Zhou, Ming1; Wen, Peng1; Wang, Qiang1; Yang, Yong1; Xiao, Hu1; Xie, Zhengyuan1; Li, Xing2; Wang, Ning3; Wang, Jinyan3; Luo, Fei3; Chang, Jingyu4; Zhang, Wangming1
2016-08-01
Source PublicationEXPERIMENTAL NEUROLOGY
ISSN0014-4886
SubtypeArticle
Volume282Issue:2016Pages:27-36
AbstractOscillatory activity has been well-studied in many structures within cortico-basal ganglia circuits, but it is not well understood within the pedunculopontine nucleus (PPN), which was recently introduced as a potential target for the treatment of gait and postural impairments in advanced stages of Parkinson's disease (PD). To investigate oscillatory activity in the PPN and its relationship with oscillatory activity in cortico-basal ganglia circuits, we simultaneously recorded local field potentials in the PPN, primary motor cortex (M1), and subthalamic nucleus (STN) of 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian rats during resting and walking. After analysis of power spectral density, coherence, and partial Granger causality, three major findings emerged: 1) after 6-OHDA lesions, beta band oscillations were enhanced in all three regions during walking; 2) the direction of information flow for beta oscillations among the three structures was STN -> M1, STN -> PPN, and PPN -> M1; 3) after the treatment of levodopa, beta activity in the three regions was reduced significantly and the flow of beta band was also abrogated. Our results suggest that beta activity in the PPN is transmitted from the basal ganglia and probably comes from the STN, and the STN plays a dominant role in the network of causal interactions for beta activity. Thus, the STN may be a potential source of aberrant beta band oscillations in PD. Levodopa can inhibit beta activity in the PPN of parkinsonian rats but cannot relieve parkinsonian patients' axial symptoms clinically. Therefore, beta oscillations may not be the major cause of axial symptoms. (C) 2016 Elsevier Inc. All rights reserved.
KeywordParkinson's Disease Parkinsonian Rats Local Field Potentials Beta Band Oscillations Pedunculopontine Nucleus Primary Motor Cortex Subthalamic Nucleus
DOI10.1016/j.expneurol.2016.05.007
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81272150)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000378460200004
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordEXTERNAL GLOBUS-PALLIDUS ; BASAL GANGLIA ; CEREBRAL-CORTEX ; DOPAMINE DEPLETION ; SUBSTANTIA-NIGRA ; DISEASE ; GAIT ; SYNCHRONIZATION ; STIMULATION ; MOVEMENT
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20029
Collection中国科学院心理健康重点实验室
Affiliation1.Southern Med Univ, Zhujiang Hosp, Engn Technol Res Ctr,Educ Minist China, Dept Neurosurg,Natl Key Clin Specialty,Guangdong, 253 Ind Ave, Guangzhou 510282, Guangdong, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Dept Neurol, 253 Ind Ave, Guangzhou 510515, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Neurosci Res Inst North Carolina, Winston Salem, NC USA
Recommended Citation
GB/T 7714
Li, Min,Zhou, Ming,Wen, Peng,et al. The network of causal interactions for beta oscillations in the pedunculopontine nucleus, primary motor cortex, and subthalamic nucleus of walking parkinsonian rats[J]. EXPERIMENTAL NEUROLOGY,2016,282(2016):27-36.
APA Li, Min.,Zhou, Ming.,Wen, Peng.,Wang, Qiang.,Yang, Yong.,...&Zhang, Wangming.(2016).The network of causal interactions for beta oscillations in the pedunculopontine nucleus, primary motor cortex, and subthalamic nucleus of walking parkinsonian rats.EXPERIMENTAL NEUROLOGY,282(2016),27-36.
MLA Li, Min,et al."The network of causal interactions for beta oscillations in the pedunculopontine nucleus, primary motor cortex, and subthalamic nucleus of walking parkinsonian rats".EXPERIMENTAL NEUROLOGY 282.2016(2016):27-36.
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