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The network of causal interactions for beta oscillations in the pedunculopontine nucleus, primary motor cortex, and subthalamic nucleus of walking parkinsonian rats
Li, Min1; Zhou, Ming1; Wen, Peng1; Wang, Qiang1; Yang, Yong1; Xiao, Hu1; Xie, Zhengyuan1; Li, Xing2; Wang, Ning3; Wang, Jinyan3; Luo, Fei3; Chang, Jingyu4; Zhang, Wangming1
2016-08-01
发表期刊EXPERIMENTAL NEUROLOGY
ISSN0014-4886
文章类型Article
卷号282期号:2016页码:27-36
摘要Oscillatory activity has been well-studied in many structures within cortico-basal ganglia circuits, but it is not well understood within the pedunculopontine nucleus (PPN), which was recently introduced as a potential target for the treatment of gait and postural impairments in advanced stages of Parkinson's disease (PD). To investigate oscillatory activity in the PPN and its relationship with oscillatory activity in cortico-basal ganglia circuits, we simultaneously recorded local field potentials in the PPN, primary motor cortex (M1), and subthalamic nucleus (STN) of 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian rats during resting and walking. After analysis of power spectral density, coherence, and partial Granger causality, three major findings emerged: 1) after 6-OHDA lesions, beta band oscillations were enhanced in all three regions during walking; 2) the direction of information flow for beta oscillations among the three structures was STN -> M1, STN -> PPN, and PPN -> M1; 3) after the treatment of levodopa, beta activity in the three regions was reduced significantly and the flow of beta band was also abrogated. Our results suggest that beta activity in the PPN is transmitted from the basal ganglia and probably comes from the STN, and the STN plays a dominant role in the network of causal interactions for beta activity. Thus, the STN may be a potential source of aberrant beta band oscillations in PD. Levodopa can inhibit beta activity in the PPN of parkinsonian rats but cannot relieve parkinsonian patients' axial symptoms clinically. Therefore, beta oscillations may not be the major cause of axial symptoms. (C) 2016 Elsevier Inc. All rights reserved.
关键词Parkinson's Disease Parkinsonian Rats Local Field Potentials Beta Band Oscillations Pedunculopontine Nucleus Primary Motor Cortex Subthalamic Nucleus
DOI10.1016/j.expneurol.2016.05.007
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81272150)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000378460200004
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]EXTERNAL GLOBUS-PALLIDUS ; BASAL GANGLIA ; CEREBRAL-CORTEX ; DOPAMINE DEPLETION ; SUBSTANTIA-NIGRA ; DISEASE ; GAIT ; SYNCHRONIZATION ; STIMULATION ; MOVEMENT
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20029
专题中国科学院心理健康重点实验室
作者单位1.Southern Med Univ, Zhujiang Hosp, Engn Technol Res Ctr,Educ Minist China, Dept Neurosurg,Natl Key Clin Specialty,Guangdong, 253 Ind Ave, Guangzhou 510282, Guangdong, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Dept Neurol, 253 Ind Ave, Guangzhou 510515, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Neurosci Res Inst North Carolina, Winston Salem, NC USA
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Li, Min,Zhou, Ming,Wen, Peng,et al. The network of causal interactions for beta oscillations in the pedunculopontine nucleus, primary motor cortex, and subthalamic nucleus of walking parkinsonian rats[J]. EXPERIMENTAL NEUROLOGY,2016,282(2016):27-36.
APA Li, Min.,Zhou, Ming.,Wen, Peng.,Wang, Qiang.,Yang, Yong.,...&Zhang, Wangming.(2016).The network of causal interactions for beta oscillations in the pedunculopontine nucleus, primary motor cortex, and subthalamic nucleus of walking parkinsonian rats.EXPERIMENTAL NEUROLOGY,282(2016),27-36.
MLA Li, Min,et al."The network of causal interactions for beta oscillations in the pedunculopontine nucleus, primary motor cortex, and subthalamic nucleus of walking parkinsonian rats".EXPERIMENTAL NEUROLOGY 282.2016(2016):27-36.
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