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African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction
Levran, Orna1; Randesi, Matthew1; Peles, Einat2,3; da Rosa, Joel Correa4; Ott, Jurg5,6; Rotrosen, John7,8; Adelson, Miriam1,2,9; Kreek, Mary Jeanne1
2016-06-01
Source PublicationPHARMACOGENOMICS
Correspondent Emaillevrano@rockefeller.edu
ISSN1462-2416
SubtypeArticle
Volume17Issue:9Pages:995-1003
AbstractAim: This study was designed to determine whether polymorphisms in acetylcholine receptors contribute to opioid dependence and/or cocaine dependence. Patients & methods: The sample (n = 1860) was divided by drug and ancestry, and 55 polymorphisms (nine genes) were analyzed. Results: Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (P-corrected = 0.047). CHRM4 is located in a region of strong linkage disequilibrium on chromosome 11 that includes genes associated with schizophrenia. CHRM4 SNP rs2229163 is in strong linkage disequilibrium with several African- specific SNPs in DGKZ and AMBRA1. Conclusion: Cholinergic receptors' variants may contribute to drug addiction and have a potential role as pharmacogenetic markers.
KeywordAfrican Ancestry Cholinergic Receptors Chrm4 Cocaine Addiction Opioid Addiction
DOI10.2217/pgs-2016-0028
Indexed BySCI
Language英语
Funding OrganizationDr Miriam and Sheldon G Adelson Medical Research Foundation ; Clinical and Translational Science from the National Center for Advancing Translational Sciences of the NIH(UL1RR024143) ; NSFC from the Chinese Government(31470070)
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000379495200004
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordNICOTINE DEPENDENCE ; CHRM2 GENE ; ALCOHOL DEPENDENCE ; NUCLEUS-ACCUMBENS ; DRUG-DEPENDENCE ; POLYMORPHISMS ; BEHAVIOR ; RISK ; SUSCEPTIBILITY ; DISORDERS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20052
Collection健康与遗传心理学研究室
Corresponding AuthorLevran, Orna
Affiliation1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Tel Aviv, Israel
3.Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
4.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA
5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
6.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
7.VA New York Harbor Healthcare Syst, New York, NY 10016 USA
8.NYU, Sch Med, New York, NY 10016 USA
9.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV 89169 USA
Recommended Citation
GB/T 7714
Levran, Orna,Randesi, Matthew,Peles, Einat,et al. African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction[J]. PHARMACOGENOMICS,2016,17(9):995-1003.
APA Levran, Orna.,Randesi, Matthew.,Peles, Einat.,da Rosa, Joel Correa.,Ott, Jurg.,...&Kreek, Mary Jeanne.(2016).African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.PHARMACOGENOMICS,17(9),995-1003.
MLA Levran, Orna,et al."African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction".PHARMACOGENOMICS 17.9(2016):995-1003.
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