| African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction | |
| Levran, Orna1; Randesi, Matthew1; Peles, Einat2,3; da Rosa, Joel Correa4; Ott, Jurg5,6; Rotrosen, John7,8; Adelson, Miriam1,2,9; Kreek, Mary Jeanne1 | |
| 通讯作者邮箱 | levrano@rockefeller.edu |
| 摘要 | Aim: This study was designed to determine whether polymorphisms in acetylcholine receptors contribute to opioid dependence and/or cocaine dependence. Patients & methods: The sample (n = 1860) was divided by drug and ancestry, and 55 polymorphisms (nine genes) were analyzed. Results: Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (P-corrected = 0.047). CHRM4 is located in a region of strong linkage disequilibrium on chromosome 11 that includes genes associated with schizophrenia. CHRM4 SNP rs2229163 is in strong linkage disequilibrium with several African- specific SNPs in DGKZ and AMBRA1. Conclusion: Cholinergic receptors' variants may contribute to drug addiction and have a potential role as pharmacogenetic markers. |
| 关键词 | African Ancestry Cholinergic Receptors Chrm4 Cocaine Addiction Opioid Addiction |
| 2016-06-01 | |
| 语种 | 英语 |
| DOI | 10.2217/pgs-2016-0028 |
| 发表期刊 | PHARMACOGENOMICS
 |
| ISSN | 1462-2416 |
| 卷号 | 17期号:9页码:995-1003 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS关键词 | NICOTINE DEPENDENCE ; CHRM2 GENE ; ALCOHOL DEPENDENCE ; NUCLEUS-ACCUMBENS ; DRUG-DEPENDENCE ; POLYMORPHISMS ; BEHAVIOR ; RISK ; SUSCEPTIBILITY ; DISORDERS |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| WOS记录号 | WOS:000379495200004 |
| 资助机构 | Dr Miriam and Sheldon G Adelson Medical Research Foundation ; Clinical and Translational Science from the National Center for Advancing Translational Sciences of the NIH(UL1RR024143) ; NSFC from the Chinese Government(31470070) |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/20052 |
| 专题 | 健康与遗传心理学研究室 |
| 通讯作者 | Levran, Orna |
| 作者单位 | 1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA 2.Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Tel Aviv, Israel 3.Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel 4.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA 5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 6.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA 7.VA New York Harbor Healthcare Syst, New York, NY 10016 USA 8.NYU, Sch Med, New York, NY 10016 USA 9.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV 89169 USA |
| 推荐引用方式 GB/T 7714 | Levran, Orna,Randesi, Matthew,Peles, Einat,et al. African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction[J]. PHARMACOGENOMICS,2016,17(9):995-1003. |
| APA | Levran, Orna.,Randesi, Matthew.,Peles, Einat.,da Rosa, Joel Correa.,Ott, Jurg.,...&Kreek, Mary Jeanne.(2016).African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.PHARMACOGENOMICS,17(9),995-1003. |
| MLA | Levran, Orna,et al."African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction".PHARMACOGENOMICS 17.9(2016):995-1003. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| African-specific var（1018KB） | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 | |
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