PSYCH OpenIR  > 健康与遗传心理学研究室
African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction
Levran, Orna1; Randesi, Matthew1; Peles, Einat2,3; da Rosa, Joel Correa4; Ott, Jurg5,6; Rotrosen, John7,8; Adelson, Miriam1,2,9; Kreek, Mary Jeanne1
2016-06-01
发表期刊PHARMACOGENOMICS
通讯作者邮箱levrano@rockefeller.edu
ISSN1462-2416
文章类型Article
卷号17期号:9页码:995-1003
摘要Aim: This study was designed to determine whether polymorphisms in acetylcholine receptors contribute to opioid dependence and/or cocaine dependence. Patients & methods: The sample (n = 1860) was divided by drug and ancestry, and 55 polymorphisms (nine genes) were analyzed. Results: Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (P-corrected = 0.047). CHRM4 is located in a region of strong linkage disequilibrium on chromosome 11 that includes genes associated with schizophrenia. CHRM4 SNP rs2229163 is in strong linkage disequilibrium with several African- specific SNPs in DGKZ and AMBRA1. Conclusion: Cholinergic receptors' variants may contribute to drug addiction and have a potential role as pharmacogenetic markers.
关键词African Ancestry Cholinergic Receptors Chrm4 Cocaine Addiction Opioid Addiction
DOI10.2217/pgs-2016-0028
收录类别SCI
语种英语
项目资助者Dr Miriam and Sheldon G Adelson Medical Research Foundation ; Clinical and Translational Science from the National Center for Advancing Translational Sciences of the NIH(UL1RR024143) ; NSFC from the Chinese Government(31470070)
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000379495200004
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]NICOTINE DEPENDENCE ; CHRM2 GENE ; ALCOHOL DEPENDENCE ; NUCLEUS-ACCUMBENS ; DRUG-DEPENDENCE ; POLYMORPHISMS ; BEHAVIOR ; RISK ; SUSCEPTIBILITY ; DISORDERS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20052
专题健康与遗传心理学研究室
通讯作者Levran, Orna
作者单位1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Tel Aviv, Israel
3.Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
4.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA
5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
6.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
7.VA New York Harbor Healthcare Syst, New York, NY 10016 USA
8.NYU, Sch Med, New York, NY 10016 USA
9.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV 89169 USA
推荐引用方式
GB/T 7714
Levran, Orna,Randesi, Matthew,Peles, Einat,et al. African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction[J]. PHARMACOGENOMICS,2016,17(9):995-1003.
APA Levran, Orna.,Randesi, Matthew.,Peles, Einat.,da Rosa, Joel Correa.,Ott, Jurg.,...&Kreek, Mary Jeanne.(2016).African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.PHARMACOGENOMICS,17(9),995-1003.
MLA Levran, Orna,et al."African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction".PHARMACOGENOMICS 17.9(2016):995-1003.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
African-specific var(1018KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Levran, Orna]的文章
[Randesi, Matthew]的文章
[Peles, Einat]的文章
百度学术
百度学术中相似的文章
[Levran, Orna]的文章
[Randesi, Matthew]的文章
[Peles, Einat]的文章
必应学术
必应学术中相似的文章
[Levran, Orna]的文章
[Randesi, Matthew]的文章
[Peles, Einat]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。