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Alternative TitleThe neuro image study on the brain cortex in schizophrenic patients and their unaffected parents
张兰兰1; 阎浩1; 田霖1; 孙伟1; 范丰梅1; 左西年1; 赵强1; 袁慧书1; 张岱1
Source Publication中国神经精神疾病杂志
Other AbstractObjective To investigate the morphological abnormalities of the brain cortex in schizophrenic patients and their parents. Methods We recruited 33 schizophrenic patients, 63 their unaffected biological parents. Thirty well matched healthy controls served as control group 1 (for patients), and 28 well matched healthy controls as control group 2 (for parents). The high-resolution magnetic resonance imaging (MRI) and Freesurfer software were used to measure the gray matter volume, cortical thickness, cortical surface area, curvature and volume of subcortical regions on all the sub-jects. Results The patients demonstrated significant reduction of cortical thickness in the left middle-anterior cingulate, middle occipital gyrus, inferior circular sulcus of the insula, lateral occipito-temporal sulcus, the right lateral occipito-temporal gyrus, middle temporal gyrus, superior circular sulcus of the insula, inferior temporal sulcus, the bilateral poste-rior-dorsalcingulated gyrus and superior temporal sulcus (P<6.0×10-4,corrected by Bonferroni method). Compared with control group 2, the unaffected parents exhibited slight reduction of cortical in the left subcentral, triangular part of the in-ferior frontal gyrus, middle frontal gyrus, superior circular sulcus of the insula, occipital pole, inferior frontal sulcus, mid-dle occipital sulcus and lunatus sulcus, lateral orbital sulcus, the right middle occipital gyrus, lingual gyrus, posterior lat- eral sulcus and inferior precentral sulcus, but the reduction was not significant after correction for multiple comparisons. Conclusions Our results indicate that cortical thickness can specifically reflect the brain morphological abnormalities of schizophrenia and the reduction of cortical thicknes may be a heritable phenotype of schizophrenia.
Keyword精神分裂症 磁共振成像 皮层厚度 遗传易感性
Subject Area变态心理学
Document Type期刊论文
Corresponding Author张岱
Affiliation1.北京大学精神卫生研究所,卫生部精神卫生学重点实验室 北京大学 北京,100191
Recommended Citation
GB/T 7714
张兰兰,阎浩,田霖,等. 精神分裂症患者及其未患病父母的脑皮层影像学研究[J]. 中国神经精神疾病杂志,2014,40(3):157-161.
APA 张兰兰.,阎浩.,田霖.,孙伟.,范丰梅.,...&张岱.(2014).精神分裂症患者及其未患病父母的脑皮层影像学研究.中国神经精神疾病杂志,40(3),157-161.
MLA 张兰兰,et al."精神分裂症患者及其未患病父母的脑皮层影像学研究".中国神经精神疾病杂志 40.3(2014):157-161.
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