The intestinal microorganisms are important symbiosis creature of human being. They affect and regulate metabolism, nutritious absorption, immunization and even live and death. Since the Gut-Brain Theory proposing, we now have recognized the gut brain is a combination system of gut neuron and gut symbiosis bacteria. Intestinal microbes influence mental and behavior of human. Human symbiosis microbes affect anxiety, depression, autism and aggressive behavior. Aggressive is a complicated behavior in human. The unpredicted behavior remain a lot of insolvable mysteries. Variety of studies so far, have focused on social, psychological and biological factors might be major impact on human aggression. In present study, we performed a case-control trial model to study aggressive behavior by comparing prisoners and ordinary people. We also attempt to explore the relationship between the gut symbiotic microorganisms and human behavior.