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Functional Reorganization of the Primary Somatosensory Cortex of a Phantom Limb Pain Patient
Zhao, Jia1; Guo, Xiaoli2; Xia, Xiaolei3,4; Peng, Weiwei3,4; Wang, Wuchao2; Li, Shulin2; Zhang, Ya3,4; Hu, Li1,3,4
2016-07-01
Source PublicationPain Physician
Correspondent Emailhuli@psych.ac.cn
ISSN1533-3159
SubtypeArticle
Volume19Issue:5Pages:E781-E786
AbstractFunctional reorganization of the somatosensory system was widely observed in phantom limb pain patients. Whereas some studies demonstrated that the primary somatosensory cortex (S1) of the amputated limb was engaged with the regions around it, others showed that phantom limb pain was associated with preserved structure and functional organization in the former brain region. However, according to the law of use and disuse, the sensitivity of S1 of the amputated limb to pain-related context should be enhanced due to the adaptation to the long-lasting phantom limb pain experience. Here, we collected neurophysiological data from a patient with 21-year phantom limb pain using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) techniques. EEG data showed that both laser-evoked potentials (LEPs) and tactile-evoked potentials (TEPs) were clearly presented only when radiant-heat laser pulses and electrical pulses were delivered to the shoulder of the healthy limb, but not of the amputated limb. This observation suggested the functional deficit of somatosensory pathways at the amputated side. FMRI data showed that significant larger brain activations by painful rather than non-painful stimuli in video clips were observed not only at visual-related brain areas and anterior/mid-cingulate cortex, but also at S1 contralateral to the amputated limb. This observation suggested the increased sensitivity of S1 of the amputated limb to the pain-related context. In addition, such increase of sensitivity was significantly larger if the context was associated with the amputated limb of the patient. In summary, our findings provided novel evidence for a possible neuroplasticity of S1 of the amputated limb: in an amputee with long-lasting phantom limb pain, the sensitivity of S1 to pain-related and amputated-limb-related context was greatly enhanced.
KeywordPhantom limb pain primary somatosensory cortex (S1) functional reorganization sensory deficit neuroplasticity functional sensitivity electroencephalography (EEG) functional magnetic resonance imaging (fMRI)
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31471082) ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences(Y6CX021008)
WOS Research AreaAnesthesiology ; Neurosciences & Neurology
WOS SubjectAnesthesiology ; Clinical Neurology
WOS IDWOS:000380688700011
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordINDEPENDENT COMPONENT ANALYSIS ; CORTICAL REORGANIZATION ; MAGNETIC STIMULATION ; AMPUTATION ; DYNAMICS ; AMPUTEES ; HUMANS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20335
Collection中国科学院心理健康重点实验室
Corresponding AuthorHu, Li
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Third Mil Med Univ, Inst Surg Res, Daping Hosp, Chongqing, Peoples R China
3.Southwest Univ, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
4.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhao, Jia,Guo, Xiaoli,Xia, Xiaolei,et al. Functional Reorganization of the Primary Somatosensory Cortex of a Phantom Limb Pain Patient[J]. Pain Physician,2016,19(5):E781-E786.
APA Zhao, Jia.,Guo, Xiaoli.,Xia, Xiaolei.,Peng, Weiwei.,Wang, Wuchao.,...&Hu, Li.(2016).Functional Reorganization of the Primary Somatosensory Cortex of a Phantom Limb Pain Patient.Pain Physician,19(5),E781-E786.
MLA Zhao, Jia,et al."Functional Reorganization of the Primary Somatosensory Cortex of a Phantom Limb Pain Patient".Pain Physician 19.5(2016):E781-E786.
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