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Functional Reorganization of the Primary Somatosensory Cortex of a Phantom Limb Pain Patient
Zhao, Jia1; Guo, Xiaoli2; Xia, Xiaolei3,4; Peng, Weiwei3,4; Wang, Wuchao2; Li, Shulin2; Zhang, Ya3,4; Hu, Li1,3,4
2016-07-01
发表期刊Pain Physician
通讯作者邮箱huli@psych.ac.cn
ISSN1533-3159
文章类型Article
卷号19期号:5页码:E781-E786
摘要Functional reorganization of the somatosensory system was widely observed in phantom limb pain patients. Whereas some studies demonstrated that the primary somatosensory cortex (S1) of the amputated limb was engaged with the regions around it, others showed that phantom limb pain was associated with preserved structure and functional organization in the former brain region. However, according to the law of use and disuse, the sensitivity of S1 of the amputated limb to pain-related context should be enhanced due to the adaptation to the long-lasting phantom limb pain experience. Here, we collected neurophysiological data from a patient with 21-year phantom limb pain using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) techniques. EEG data showed that both laser-evoked potentials (LEPs) and tactile-evoked potentials (TEPs) were clearly presented only when radiant-heat laser pulses and electrical pulses were delivered to the shoulder of the healthy limb, but not of the amputated limb. This observation suggested the functional deficit of somatosensory pathways at the amputated side. FMRI data showed that significant larger brain activations by painful rather than non-painful stimuli in video clips were observed not only at visual-related brain areas and anterior/mid-cingulate cortex, but also at S1 contralateral to the amputated limb. This observation suggested the increased sensitivity of S1 of the amputated limb to the pain-related context. In addition, such increase of sensitivity was significantly larger if the context was associated with the amputated limb of the patient. In summary, our findings provided novel evidence for a possible neuroplasticity of S1 of the amputated limb: in an amputee with long-lasting phantom limb pain, the sensitivity of S1 to pain-related and amputated-limb-related context was greatly enhanced.
关键词Phantom limb pain primary somatosensory cortex (S1) functional reorganization sensory deficit neuroplasticity functional sensitivity electroencephalography (EEG) functional magnetic resonance imaging (fMRI)
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31471082) ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences(Y6CX021008)
WOS研究方向Anesthesiology ; Neurosciences & Neurology
WOS类目Anesthesiology ; Clinical Neurology
WOS记录号WOS:000380688700011
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]INDEPENDENT COMPONENT ANALYSIS ; CORTICAL REORGANIZATION ; MAGNETIC STIMULATION ; AMPUTATION ; DYNAMICS ; AMPUTEES ; HUMANS
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20335
专题中国科学院心理健康重点实验室
通讯作者Hu, Li
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Third Mil Med Univ, Inst Surg Res, Daping Hosp, Chongqing, Peoples R China
3.Southwest Univ, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
4.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Jia,Guo, Xiaoli,Xia, Xiaolei,et al. Functional Reorganization of the Primary Somatosensory Cortex of a Phantom Limb Pain Patient[J]. Pain Physician,2016,19(5):E781-E786.
APA Zhao, Jia.,Guo, Xiaoli.,Xia, Xiaolei.,Peng, Weiwei.,Wang, Wuchao.,...&Hu, Li.(2016).Functional Reorganization of the Primary Somatosensory Cortex of a Phantom Limb Pain Patient.Pain Physician,19(5),E781-E786.
MLA Zhao, Jia,et al."Functional Reorganization of the Primary Somatosensory Cortex of a Phantom Limb Pain Patient".Pain Physician 19.5(2016):E781-E786.
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