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Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients
Yu, Jing1,3; Li, Rui1; Jiang, Yang2; Broster, Lucas S.2; Li, Juan1,4; Li, J
2016
Source PublicationJOURNAL OF ALZHEIMERS DISEASE
Correspondent Emaillijuan@psych.ac.cn
ISSN1387-2877
SubtypeArticle
Volume53Issue:2Pages:693-704
AbstractOlder adults with mild cognitive impairment (MCI) manifest impaired explicit memory. However, studies on implicit memory such as repetition effects in persons with MCI have been limited. In the present study, 17 MCI patients and 16 healthy normal controls (NC) completed a modified delayed-match-to-sample task while undergoing functional magnetic resonance imaging. We aim to examine the neural basis of repetition; specifically, to elucidate whether and how repetition-related brain responses are altered in participants with MCI. When repeatedly rejecting distracters, both NC and MCI showed similar behavioral repetition effects; however, in both whole-brain and region-of-interest analyses of functional data, persons with MCI showed reduced repetition-driven suppression in the middle occipital and middle frontal gyrus. Further, individual difference analysis found that activation in the left middle occipital gyrus was positively correlated with rejecting reaction time and negatively correlated with accuracy rate, suggesting a predictor of repetition behavioral performance. These findings provide new evidence to support the view that neural mechanisms of repetition effect are altered in MCI who manifests compensatory repetition-related brain activities along with their neuropathology.
KeywordDelayed-match-to-sample task functional MRI mild cognitive impairment repetition repetition suppression
Subject Area老年心理学
DOI10.3233/JAD-160086
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31470998 ; National Science & Technology Pillar Program of China(2009BAI77B03) ; CAS/SAFEA International Partnership Program for Creative Research Team(Y2CX131003) ; Scientific Foundation of Institute of Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZK02) ; United States NIH grants National Institute of Aging(AG000986 ; 31271108 ; T32 AG000242 ; 31200847 ; P30AG028383 ; 31300856) ; UL1TR000117)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000381207500025
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDEFAULT-MODE NETWORK ; EVENT-RELATED FMRI ; ALZHEIMERS-DISEASE ; IMPLICIT MEMORY ; WORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; RECOGNITION MEMORY ; HIPPOCAMPAL ; MCI ; METAANALYSIS
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20366
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, J
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China
2.Univ Kentucky, Coll Med, Lexington, KY USA
3.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
4.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yu, Jing,Li, Rui,Jiang, Yang,et al. Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients[J]. JOURNAL OF ALZHEIMERS DISEASE,2016,53(2):693-704.
APA Yu, Jing,Li, Rui,Jiang, Yang,Broster, Lucas S.,Li, Juan,&Li, J.(2016).Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients.JOURNAL OF ALZHEIMERS DISEASE,53(2),693-704.
MLA Yu, Jing,et al."Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients".JOURNAL OF ALZHEIMERS DISEASE 53.2(2016):693-704.
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