Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients

doi:10.3233/JAD-160086

	Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients
	Yu, Jing1,3 ; Li, Rui1 ; Jiang, Yang 2; Broster, Lucas S.2; Li, Juan1,4 ; Li, J
通讯作者邮箱	lijuan@psych.ac.cn
摘要	Older adults with mild cognitive impairment (MCI) manifest impaired explicit memory. However, studies on implicit memory such as repetition effects in persons with MCI have been limited. In the present study, 17 MCI patients and 16 healthy normal controls (NC) completed a modified delayed-match-to-sample task while undergoing functional magnetic resonance imaging. We aim to examine the neural basis of repetition; specifically, to elucidate whether and how repetition-related brain responses are altered in participants with MCI. When repeatedly rejecting distracters, both NC and MCI showed similar behavioral repetition effects; however, in both whole-brain and region-of-interest analyses of functional data, persons with MCI showed reduced repetition-driven suppression in the middle occipital and middle frontal gyrus. Further, individual difference analysis found that activation in the left middle occipital gyrus was positively correlated with rejecting reaction time and negatively correlated with accuracy rate, suggesting a predictor of repetition behavioral performance. These findings provide new evidence to support the view that neural mechanisms of repetition effect are altered in MCI who manifests compensatory repetition-related brain activities along with their neuropathology.
关键词	Delayed-match-to-sample task functional MRI mild cognitive impairment repetition repetition suppression
学科领域	老年心理学
	2016
语种	英语
DOI	10.3233/JAD-160086
发表期刊	JOURNAL OF ALZHEIMERS DISEASE
ISSN	1387-2877
卷号	53 期号:2 页码:693-704
期刊论文类型	Article
收录类别	SCI
WOS关键词	DEFAULT-MODE NETWORK ; EVENT-RELATED FMRI ; ALZHEIMERS-DISEASE ; IMPLICIT MEMORY ; WORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; RECOGNITION MEMORY ; HIPPOCAMPAL ; MCI ; METAANALYSIS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000381207500025
资助机构	National Natural Science Foundation of China(31470998 ; National Science & Technology Pillar Program of China(2009BAI77B03) ; CAS/SAFEA International Partnership Program for Creative Research Team(Y2CX131003) ; Scientific Foundation of Institute of Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZK02) ; United States NIH grants National Institute of Aging(AG000986 ; 31271108 ; T32 AG000242 ; 31200847 ; P30AG028383 ; 31300856) ; UL1TR000117)
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20366
专题	中国科学院心理健康重点实验室
通讯作者	Li, J
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China 2.Univ Kentucky, Coll Med, Lexington, KY USA 3.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 4.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Yu, Jing,Li, Rui,Jiang, Yang,et al. Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients[J]. JOURNAL OF ALZHEIMERS DISEASE,2016,53(2):693-704.
APA	Yu, Jing,Li, Rui,Jiang, Yang,Broster, Lucas S.,Li, Juan,&Li, J.(2016).Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients.JOURNAL OF ALZHEIMERS DISEASE,53(2),693-704.
MLA	Yu, Jing,et al."Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients".JOURNAL OF ALZHEIMERS DISEASE 53.2(2016):693-704.

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