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Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients
Yu, Jing1,3; Li, Rui1; Jiang, Yang2; Broster, Lucas S.2; Li, Juan1,4; Li, J
2016
发表期刊JOURNAL OF ALZHEIMERS DISEASE
通讯作者邮箱lijuan@psych.ac.cn
ISSN1387-2877
文章类型Article
卷号53期号:2页码:693-704
摘要Older adults with mild cognitive impairment (MCI) manifest impaired explicit memory. However, studies on implicit memory such as repetition effects in persons with MCI have been limited. In the present study, 17 MCI patients and 16 healthy normal controls (NC) completed a modified delayed-match-to-sample task while undergoing functional magnetic resonance imaging. We aim to examine the neural basis of repetition; specifically, to elucidate whether and how repetition-related brain responses are altered in participants with MCI. When repeatedly rejecting distracters, both NC and MCI showed similar behavioral repetition effects; however, in both whole-brain and region-of-interest analyses of functional data, persons with MCI showed reduced repetition-driven suppression in the middle occipital and middle frontal gyrus. Further, individual difference analysis found that activation in the left middle occipital gyrus was positively correlated with rejecting reaction time and negatively correlated with accuracy rate, suggesting a predictor of repetition behavioral performance. These findings provide new evidence to support the view that neural mechanisms of repetition effect are altered in MCI who manifests compensatory repetition-related brain activities along with their neuropathology.
关键词Delayed-match-to-sample task functional MRI mild cognitive impairment repetition repetition suppression
学科领域老年心理学
DOI10.3233/JAD-160086
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31470998 ; National Science & Technology Pillar Program of China(2009BAI77B03) ; CAS/SAFEA International Partnership Program for Creative Research Team(Y2CX131003) ; Scientific Foundation of Institute of Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZK02) ; United States NIH grants National Institute of Aging(AG000986 ; 31271108 ; T32 AG000242 ; 31200847 ; P30AG028383 ; 31300856) ; UL1TR000117)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000381207500025
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]DEFAULT-MODE NETWORK ; EVENT-RELATED FMRI ; ALZHEIMERS-DISEASE ; IMPLICIT MEMORY ; WORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; RECOGNITION MEMORY ; HIPPOCAMPAL ; MCI ; METAANALYSIS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20366
专题中国科学院心理健康重点实验室
通讯作者Li, J
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China
2.Univ Kentucky, Coll Med, Lexington, KY USA
3.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
4.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
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Yu, Jing,Li, Rui,Jiang, Yang,et al. Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients[J]. JOURNAL OF ALZHEIMERS DISEASE,2016,53(2):693-704.
APA Yu, Jing,Li, Rui,Jiang, Yang,Broster, Lucas S.,Li, Juan,&Li, J.(2016).Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients.JOURNAL OF ALZHEIMERS DISEASE,53(2),693-704.
MLA Yu, Jing,et al."Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients".JOURNAL OF ALZHEIMERS DISEASE 53.2(2016):693-704.
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