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Sex-Specific Mediation Effect of the Right Fusiform Face Area Volume on the Association Between Variants in Repeat Length of AVPR1A RS3 and Altruistic Behavior in Healthy Adults
Wang, Junping1,2; Qin, Wen1,2; Liu, Feng1,2; Liu, Bing3,4; Zhou, Yuan5; Jiang, Tianzi3,4; Yu, Chunshui1,2
2016-07-01
Source PublicationHUMAN BRAIN MAPPING
Correspondent Emailchun-shuiyu@tijmu.edu.cn
ISSN1065-9471
SubtypeArticle
Volume37Issue:7Pages:2700-2709
AbstractMicrosatellite variants in the arginine vasopressin receptor 1A gene (AVPR1A) RS3 have been associated with normal social behaviors variation and autism spectrum disorders (ASDs) in a sex-specific manner. However, neural mechanisms underlying these associations remain largely unknown. We hypothesized that AVPR1A RS3 variants affect altruistic behavior by modulating the gray matter volume (GMV) of specific brain regions in a sex-specific manner. We investigated 278 young healthy adults using the Dictator Game to assess altruistic behavior. All subjects were genotyped and main effect of AVPR1A RS3 repeat polymorphisms and interaction of genotype-by-sex on the GMV were assessed in a voxel-wise manner. We observed that male subjects with relatively short repeats allocated less money to others and exhibited a significantly smaller GMV in the right fusiform face area (FFA) compared with male long homozygotes. In male subjects, the GMV of the right FFA exhibited a significant positive correlation with altruistic behavior. A mixed mediation and moderation analysis further revealed both a significant mediation effect of the GMV of the right FFA on the association between AVPR1A RS3 repeat polymorphisms and allocation sums and a significant moderation effect of sex (only in males) on the mediation effect. Post hoc analysis showed that the GMV of the right FFA was significantly smaller in male subjects carrying allele 426 than in non-426 carriers. These results suggest that the GMV of the right FFA may be a potential mediator whereby the genetic variants in AVPR1A RS3 affect altruistic behavior in healthy male subjects. (C) 2016 Wiley Periodicals, Inc.
Keywordautism spectrum disorder arginine vasopressin receptor 1A fusiform face area gray matter volume microsatellite mediation analysis
DOI10.1002/hbm.23203
Indexed BySCI ; SSCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000382488800024
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordSTATE FUNCTIONAL CONNECTIVITY ; SPECTRUM DISORDER ; PROMOTER REGION ; FLANKING REGION ; BRAIN RESPONSES ; MESSENGER-RNA ; RECEPTOR GENE ; VASOPRESSIN ; AUTISM ; OXYTOCIN
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20394
Collection社会与工程心理学研究室
Corresponding AuthorYu, Chunshui
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Ctr Social & Econ Behav, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Junping,Qin, Wen,Liu, Feng,et al. Sex-Specific Mediation Effect of the Right Fusiform Face Area Volume on the Association Between Variants in Repeat Length of AVPR1A RS3 and Altruistic Behavior in Healthy Adults[J]. HUMAN BRAIN MAPPING,2016,37(7):2700-2709.
APA Wang, Junping.,Qin, Wen.,Liu, Feng.,Liu, Bing.,Zhou, Yuan.,...&Yu, Chunshui.(2016).Sex-Specific Mediation Effect of the Right Fusiform Face Area Volume on the Association Between Variants in Repeat Length of AVPR1A RS3 and Altruistic Behavior in Healthy Adults.HUMAN BRAIN MAPPING,37(7),2700-2709.
MLA Wang, Junping,et al."Sex-Specific Mediation Effect of the Right Fusiform Face Area Volume on the Association Between Variants in Repeat Length of AVPR1A RS3 and Altruistic Behavior in Healthy Adults".HUMAN BRAIN MAPPING 37.7(2016):2700-2709.
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