| Sex-Specific Mediation Effect of the Right Fusiform Face Area Volume on the Association Between Variants in Repeat Length of AVPR1A RS3 and Altruistic Behavior in Healthy Adults | |
Wang, Junping1,2; Qin, Wen1,2; Liu, Feng1,2; Liu, Bing3,4; Zhou, Yuan5 ; Jiang, Tianzi3,4; Yu, Chunshui1,2
| |
| 通讯作者邮箱 | chun-shuiyu@tijmu.edu.cn |
| 摘要 | Microsatellite variants in the arginine vasopressin receptor 1A gene (AVPR1A) RS3 have been associated with normal social behaviors variation and autism spectrum disorders (ASDs) in a sex-specific manner. However, neural mechanisms underlying these associations remain largely unknown. We hypothesized that AVPR1A RS3 variants affect altruistic behavior by modulating the gray matter volume (GMV) of specific brain regions in a sex-specific manner. We investigated 278 young healthy adults using the Dictator Game to assess altruistic behavior. All subjects were genotyped and main effect of AVPR1A RS3 repeat polymorphisms and interaction of genotype-by-sex on the GMV were assessed in a voxel-wise manner. We observed that male subjects with relatively short repeats allocated less money to others and exhibited a significantly smaller GMV in the right fusiform face area (FFA) compared with male long homozygotes. In male subjects, the GMV of the right FFA exhibited a significant positive correlation with altruistic behavior. A mixed mediation and moderation analysis further revealed both a significant mediation effect of the GMV of the right FFA on the association between AVPR1A RS3 repeat polymorphisms and allocation sums and a significant moderation effect of sex (only in males) on the mediation effect. Post hoc analysis showed that the GMV of the right FFA was significantly smaller in male subjects carrying allele 426 than in non-426 carriers. These results suggest that the GMV of the right FFA may be a potential mediator whereby the genetic variants in AVPR1A RS3 affect altruistic behavior in healthy male subjects. (C) 2016 Wiley Periodicals, Inc. |
| 关键词 | autism spectrum disorder arginine vasopressin receptor 1A fusiform face area gray matter volume microsatellite mediation analysis |
| 2016-07-01 | |
| 语种 | 英语 |
| DOI | 10.1002/hbm.23203 |
| 发表期刊 | HUMAN BRAIN MAPPING
 |
| ISSN | 1065-9471 |
| 卷号 | 37期号:7页码:2700-2709 |
| 期刊论文类型 | Article |
| 收录类别 | SCI ; SSCI |
| WOS关键词 | STATE FUNCTIONAL CONNECTIVITY ; SPECTRUM DISORDER ; PROMOTER REGION ; FLANKING REGION ; BRAIN RESPONSES ; MESSENGER-RNA ; RECEPTOR GENE ; VASOPRESSIN ; AUTISM ; OXYTOCIN |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS记录号 | WOS:000382488800024 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/20394 |
| 专题 | 社会与工程心理学研究室 |
| 通讯作者 | Yu, Chunshui |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Ctr Social & Econ Behav, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Junping,Qin, Wen,Liu, Feng,et al. Sex-Specific Mediation Effect of the Right Fusiform Face Area Volume on the Association Between Variants in Repeat Length of AVPR1A RS3 and Altruistic Behavior in Healthy Adults[J]. HUMAN BRAIN MAPPING,2016,37(7):2700-2709. |
| APA | Wang, Junping.,Qin, Wen.,Liu, Feng.,Liu, Bing.,Zhou, Yuan.,...&Yu, Chunshui.(2016).Sex-Specific Mediation Effect of the Right Fusiform Face Area Volume on the Association Between Variants in Repeat Length of AVPR1A RS3 and Altruistic Behavior in Healthy Adults.HUMAN BRAIN MAPPING,37(7),2700-2709. |
| MLA | Wang, Junping,et al."Sex-Specific Mediation Effect of the Right Fusiform Face Area Volume on the Association Between Variants in Repeat Length of AVPR1A RS3 and Altruistic Behavior in Healthy Adults".HUMAN BRAIN MAPPING 37.7(2016):2700-2709. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Sex-specific mediati（246KB） | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论