Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy

doi:10.1016/j.pscychresnc.2016.06.014

	Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy
	Yan, Chao1,2 ; Wang, Yi2 ; Su, Li 3; Xu, Ting2 ; Yin, Da-zhi 4; Fan, Ming-xia 5; Deng, Ci-ping 1; Wang, Zhao-xin 1; Lui, Simon S. Y.2,6; Cheung, Eric F. C.6; Chan, Raymond C. K.2
通讯作者邮箱	ckchan@psych.ac.cn
摘要	Schizotypy is associated with anhedonia. However, previous findings on the neural substrates of anhedonia in schizotypy are mixed. In the present study, we measured the neural substrates associated with reward anticipation and consummation in positive and negative schizotypy using functional MRI. The Monetary Incentive Delay task was administered to 33 individuals with schizotypy (18 positive schizotypy (P5),15 negative schizotypy (NS)) and 22 healthy controls. Comparison between schizotypy individuals and controls were performed using two-sample T tests for contrast images involving gain versus non-gain anticipation condition and gain versus non-gain consummation condition. Multiple comparisons were corrected using Monte Carlo Simulation correction of p < .05. The results showed no significant difference in brain activity between controls and schizotypy individuals as a whole during gain anticipation or consummation. However, during the consummatory phase, NS individuals rather than PS individuals showed diminished left amygdala and left putamen activity compared with controls. We observed significantly weaker activation at the left ventral striatum during gain anticipation in NS individuals compared with controls. PS individuals, however, exhibited enhanced right ventral lateral prefrontal activity. These findings suggest that different dimensions of schizotypy may be underlied by different neural dysfunctions in reward anticipation and consummation. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
关键词	Negative schizotypy Positive schizotypy fMRI Reward anticipation Reward consummation
	2016-08-30
语种	英语
DOI	10.1016/j.pscychresnc.2016.06.014
发表期刊	PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN	0925-4927
卷号	254 期号:0 页码:127-136
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	UNAFFECTED SIBLINGS ; NUCLEUS-ACCUMBENS ; SOCIAL ANHEDONIA ; SCHIZOPHRENIA ; EMOTION ; EXPERIENCE ; FMRI ; PERSONALITY ; EXPRESSION ; PSYCHOSIS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Neuroimaging ; Psychiatry
WOS记录号	WOS:000382316000017
资助机构	National Science Fund China(81088001 ; Strategic Priority Research Programme (B) of the Chinese Academy of Sciences(XDB02030002) ; Beijing Training Project for Leading Talents in S T(Z151100000315020) ; initiation fund of the CAS/SAFEA International Partnership Programme for Creative Research Team(Y2CX131003) ; 81571317 ; 91132701 ; 31500894)
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20395
专题	中国科学院心理健康重点实验室
通讯作者	Chan, Raymond C. K.
作者单位	1.East China Normal Univ, Shanghai Key Lab Brain Funct Genom MOE STCSM, Minist Educ, Key Lab Brain Funct Genom, Shanghai, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 3.Univ Cambridge, Dept Psychiat, Cambridge Biomed Campus, Cambridge, England 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China 5.East China Normal Univ, Shanghai Key Lab MRI, Shanghai, Peoples R China 6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
第一作者单位	认知与发展心理学研究室
通讯作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Yan, Chao,Wang, Yi,Su, Li,et al. Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2016,254(0):127-136.
APA	Yan, Chao.,Wang, Yi.,Su, Li.,Xu, Ting.,Yin, Da-zhi.,...&Chan, Raymond C. K..(2016).Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy.PSYCHIATRY RESEARCH-NEUROIMAGING,254(0),127-136.
MLA	Yan, Chao,et al."Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy".PSYCHIATRY RESEARCH-NEUROIMAGING 254.0(2016):127-136.

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