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Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy
Yan, Chao1,2; Wang, Yi2; Su, Li3; Xu, Ting2; Yin, Da-zhi4; Fan, Ming-xia5; Deng, Ci-ping1; Wang, Zhao-xin1; Lui, Simon S. Y.2,6; Cheung, Eric F. C.6; Chan, Raymond C. K.2
2016-08-30
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
Correspondent Emailckchan@psych.ac.cn
ISSN0925-4927
SubtypeArticle
Volume254Issue:0Pages:127-136
AbstractSchizotypy is associated with anhedonia. However, previous findings on the neural substrates of anhedonia in schizotypy are mixed. In the present study, we measured the neural substrates associated with reward anticipation and consummation in positive and negative schizotypy using functional MRI. The Monetary Incentive Delay task was administered to 33 individuals with schizotypy (18 positive schizotypy (P5),15 negative schizotypy (NS)) and 22 healthy controls. Comparison between schizotypy individuals and controls were performed using two-sample T tests for contrast images involving gain versus non-gain anticipation condition and gain versus non-gain consummation condition. Multiple comparisons were corrected using Monte Carlo Simulation correction of p < .05. The results showed no significant difference in brain activity between controls and schizotypy individuals as a whole during gain anticipation or consummation. However, during the consummatory phase, NS individuals rather than PS individuals showed diminished left amygdala and left putamen activity compared with controls. We observed significantly weaker activation at the left ventral striatum during gain anticipation in NS individuals compared with controls. PS individuals, however, exhibited enhanced right ventral lateral prefrontal activity. These findings suggest that different dimensions of schizotypy may be underlied by different neural dysfunctions in reward anticipation and consummation. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
KeywordNegative schizotypy Positive schizotypy fMRI Reward anticipation Reward consummation
DOI10.1016/j.pscychresnc.2016.06.014
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Science Fund China(81088001 ; Strategic Priority Research Programme (B) of the Chinese Academy of Sciences(XDB02030002) ; Beijing Training Project for Leading Talents in S T(Z151100000315020) ; initiation fund of the CAS/SAFEA International Partnership Programme for Creative Research Team(Y2CX131003) ; 81571317 ; 91132701 ; 31500894)
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000382316000017
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordUNAFFECTED SIBLINGS ; NUCLEUS-ACCUMBENS ; SOCIAL ANHEDONIA ; SCHIZOPHRENIA ; EMOTION ; EXPERIENCE ; FMRI ; PERSONALITY ; EXPRESSION ; PSYCHOSIS
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20395
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.East China Normal Univ, Shanghai Key Lab Brain Funct Genom MOE STCSM, Minist Educ, Key Lab Brain Funct Genom, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
3.Univ Cambridge, Dept Psychiat, Cambridge Biomed Campus, Cambridge, England
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China
5.East China Normal Univ, Shanghai Key Lab MRI, Shanghai, Peoples R China
6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Yan, Chao,Wang, Yi,Su, Li,et al. Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2016,254(0):127-136.
APA Yan, Chao.,Wang, Yi.,Su, Li.,Xu, Ting.,Yin, Da-zhi.,...&Chan, Raymond C. K..(2016).Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy.PSYCHIATRY RESEARCH-NEUROIMAGING,254(0),127-136.
MLA Yan, Chao,et al."Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy".PSYCHIATRY RESEARCH-NEUROIMAGING 254.0(2016):127-136.
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