With the socio-economic development and environmental changes, people’s lifestyles have changed greatly. Lots of studies have found that lifestyles have important impact on people’s health and diseases caused by unhealthy lifestyles happen more and more. Adolescence is a critical period to establish good habits and lifestyles and it will affect health and quality of life in later time. Our study aims to make Chinese Adolescent Lifestyles Scale (CALS) which has good reliability and validity. And on this basis, to analyze situations and characteristics of lifestyles among Chinese adolescents as well as explore its relationships with self-esteem and depression. Main results below: Firstly, based on references and expert discussion, the Chinese Adolescent Lifestyles Scale (CALS) was made and tested. All index fit the statistical standards basically. Secondly, lifestyles of Chinese adolescents were good except physical activity. Adolescents in big city, key school, high school and singletons had best lifestyles. Thirdly, lifestyles could be divided into healthy lifestyles and unhealthy lifestyles. With life satisfaction, it can be divided into four kinds: healthy lifestyles and high life satisfaction; healthy lifestyles and low life satisfaction; unhealthy lifestyles and high life satisfaction; unhealthy lifestyles and low life satisfaction. At last, lifestyles directly predicted life satisfaction significantly. And it can impact life satisfaction through self-esteem and depression indirectly.