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Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia
Huang, Jia1; Yang, Xin-hua1,2; Lan, Yong2; Zhu, Cui-ying2; Liu, Xiao-qun3; Wang, Ye-fei4; Cheung, Eric F. C.5; Xie, Guang-rong4; Chan, Raymond C. K.1
2016-09-01
Source PublicationNEUROPSYCHOLOGY
Correspondent Emailrckchan@psych.ac.cn
ISSN0894-4105
SubtypeArticle
Volume30Issue:6Pages:685-696
AbstractObjective: Unwillingness to expend more effort to pursue high value rewards has been associated with motivational anhedonia in schizophrenia (SCZ) and abnormal dopamine activity in the nucleus accumbens (NAcc). The authors hypothesized that dysfunction of the NAcc and the associated forebrain regions are involved in the impaired effort expenditure decision-making of SCZ. Method: A 2 (reward magnitude: low vs. high) x 3 (probability: 20% vs. 50% vs. 80%) event-related fMRI design in the effort-expenditure for reward task (EEfRT) was used to examine the neural response of 23 SCZ patients and 23 demographically matched control participants when the participants made effort expenditure decisions to pursue uncertain rewards. Results: SCZ patients were significantly less likely to expend high level of effort in the medium (50%) and high (80%) probability conditions than healthy controls. The neural response in the NAcc, the posterior cingulate gyrus and the left medial frontal gyrus in SCZ patients were weaker than healthy controls and did not linearly increase with an increase in reward magnitude and probability. Moreover, NAcc activity was positively correlated with the willingness to expend high-level effort and concrete consummatory pleasure experience. Conclusion: NAcc and posterior cingulate dysfunctions in SCZ patients may be involved in their impaired effort expenditure decision-making.
KeywordEfFort Expenditure For Reward Task Motivation Schizophrenia Fmri
DOI10.1037/neu0000284
Indexed BySCI ; SSCI
Language英语
Funding Organization"Strategic Priority Research Program (B)" of the Chinese Academy of Sciences(XDB02030002) ; National Science Fund China(81088001 ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Key Laboratory of Mental Health, Institute of Psychology ; 91132701 ; 81571317 ; 31100747)
WOS Research AreaPsychology ; Neurosciences & Neurology
WOS SubjectPsychology, Clinical ; Neurosciences ; Psychology
WOS IDWOS:000383879300004
WOS HeadingsSocial Sciences ; Science & Technology ; Life Sciences & Biomedicine
WOS KeywordPOSTERIOR CINGULATE CORTEX ; NEGATIVE SYMPTOMS ; MOTIVATIONAL DEFICITS ; EFFORT COMPUTATION ; EFFORT ALLOCATION ; REWARDS TASK ; HUMAN BRAIN ; ANHEDONIA ; DOPAMINE ; PLEASURE
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20464
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Hong Kong, Hong Kong, Peoples R China
2.Hunan Agr Univ, Inst Educ, Rural Children & Adolescents Res Ctr Hlth Promot, Hong Kong, Hong Kong, Peoples R China
3.Cent S Univ, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China
4.Cent S Univ, Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Xiangya Hosp 2, Hong Kong, Hong Kong, Peoples R China
5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Huang, Jia,Yang, Xin-hua,Lan, Yong,et al. Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia[J]. NEUROPSYCHOLOGY,2016,30(6):685-696.
APA Huang, Jia.,Yang, Xin-hua.,Lan, Yong.,Zhu, Cui-ying.,Liu, Xiao-qun.,...&Chan, Raymond C. K..(2016).Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia.NEUROPSYCHOLOGY,30(6),685-696.
MLA Huang, Jia,et al."Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia".NEUROPSYCHOLOGY 30.6(2016):685-696.
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