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Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia
Huang, Jia1; Yang, Xin-hua1,2; Lan, Yong2; Zhu, Cui-ying2; Liu, Xiao-qun3; Wang, Ye-fei4; Cheung, Eric F. C.5; Xie, Guang-rong4; Chan, Raymond C. K.1
2016-09-01
发表期刊NEUROPSYCHOLOGY
通讯作者邮箱rckchan@psych.ac.cn
ISSN0894-4105
文章类型Article
卷号30期号:6页码:685-696
摘要Objective: Unwillingness to expend more effort to pursue high value rewards has been associated with motivational anhedonia in schizophrenia (SCZ) and abnormal dopamine activity in the nucleus accumbens (NAcc). The authors hypothesized that dysfunction of the NAcc and the associated forebrain regions are involved in the impaired effort expenditure decision-making of SCZ. Method: A 2 (reward magnitude: low vs. high) x 3 (probability: 20% vs. 50% vs. 80%) event-related fMRI design in the effort-expenditure for reward task (EEfRT) was used to examine the neural response of 23 SCZ patients and 23 demographically matched control participants when the participants made effort expenditure decisions to pursue uncertain rewards. Results: SCZ patients were significantly less likely to expend high level of effort in the medium (50%) and high (80%) probability conditions than healthy controls. The neural response in the NAcc, the posterior cingulate gyrus and the left medial frontal gyrus in SCZ patients were weaker than healthy controls and did not linearly increase with an increase in reward magnitude and probability. Moreover, NAcc activity was positively correlated with the willingness to expend high-level effort and concrete consummatory pleasure experience. Conclusion: NAcc and posterior cingulate dysfunctions in SCZ patients may be involved in their impaired effort expenditure decision-making.
关键词EfFort Expenditure For Reward Task Motivation Schizophrenia Fmri
DOI10.1037/neu0000284
收录类别SCI ; SSCI
语种英语
项目资助者"Strategic Priority Research Program (B)" of the Chinese Academy of Sciences(XDB02030002) ; National Science Fund China(81088001 ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Key Laboratory of Mental Health, Institute of Psychology ; 91132701 ; 81571317 ; 31100747)
WOS研究方向Psychology ; Neurosciences & Neurology
WOS类目Psychology, Clinical ; Neurosciences ; Psychology
WOS记录号WOS:000383879300004
WOS标题词Social Sciences ; Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]POSTERIOR CINGULATE CORTEX ; NEGATIVE SYMPTOMS ; MOTIVATIONAL DEFICITS ; EFFORT COMPUTATION ; EFFORT ALLOCATION ; REWARDS TASK ; HUMAN BRAIN ; ANHEDONIA ; DOPAMINE ; PLEASURE
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20464
专题中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Hong Kong, Hong Kong, Peoples R China
2.Hunan Agr Univ, Inst Educ, Rural Children & Adolescents Res Ctr Hlth Promot, Hong Kong, Hong Kong, Peoples R China
3.Cent S Univ, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China
4.Cent S Univ, Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Xiangya Hosp 2, Hong Kong, Hong Kong, Peoples R China
5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
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Huang, Jia,Yang, Xin-hua,Lan, Yong,et al. Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia[J]. NEUROPSYCHOLOGY,2016,30(6):685-696.
APA Huang, Jia.,Yang, Xin-hua.,Lan, Yong.,Zhu, Cui-ying.,Liu, Xiao-qun.,...&Chan, Raymond C. K..(2016).Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia.NEUROPSYCHOLOGY,30(6),685-696.
MLA Huang, Jia,et al."Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia".NEUROPSYCHOLOGY 30.6(2016):685-696.
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