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Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates
Opitz, Alexander1,2; Falchier, Arnaud1; Yan, Chao-Gan1,3,4; Yeagle, Erin M.5,6; Linn, Gary S.1,7; Megevand, Pierre5,6; Thielscher, Axel8,9,10; Ross, Deborah A.1; Milham, Michael P.1,2; Mehta, Ashesh D.5,6; Schroeder, Charles E.1,11,12; Charles E. Schroeder
2016-08-18
发表期刊SCIENTIFIC REPORTS
通讯作者邮箱aopitz@nki.rfmh.org
ISSN2045-2322
文章类型Article
卷号6期号:0页码:1-11
摘要Transcranial electric stimulation (TES) is an emerging technique, developed to non-invasively modulate brain function. However, the spatiotemporal distribution of the intracranial electric fields induced by TES remains poorly understood. In particular, it is unclear how much current actually reaches the brain, and how it distributes across the brain. Lack of this basic information precludes a firm mechanistic understanding of TES effects. In this study we directly measure the spatial and temporal characteristics of the electric field generated by TES using stereotactic EEG (s-EEG) electrode arrays implanted in cebus monkeys and surgical epilepsy patients. We found a small frequency dependent decrease (10%) in magnitudes of TES induced potentials and negligible phase shifts over space. Electric field strengths were strongest in superficial brain regions with maximum values of about 0.5 mV/mm. Our results provide crucial information of the underlying biophysics in TES applications in humans and the optimization and design of TES stimulation protocols. In addition, our findings have broad implications concerning electric field propagation in non-invasive recording techniques such as EEG/MEG.
DOI10.1038/srep31236
收录类别SCI
语种英语
项目资助者Nathan S. Kline Institute for Psychiatric Research (NKI) ; Child Mind Institute(1FD2013-1) ; Lundbeck foundation(R118-A11308 ; NovoNordisk foundation(11413) ; (MH110217) ; R59 A5399)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000381557200001
WOS标题词Science & Technology
关键词[WOS]ALTERNATING-CURRENT STIMULATION ; BRAIN-STIMULATION ; NETWORK ACTIVITY ; MOTOR CORTEX ; EXCITABILITY ; ENTRAINMENT ; FREQUENCIES ; RECIPROCITY ; SPECTRUM ; CURRENTS
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20519
专题中国科学院行为科学重点实验室
通讯作者Charles E. Schroeder
作者单位1.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
2.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA
3.Chinese Acad Sci, Key Lab Behav Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
5.Hofstra Northwell Sch Med, Dept Neurosurg, Manhasset, NY USA
6.Feinstein Inst Med Res, Manhasset, NY USA
7.NYU, Langone Sch Med, Dept Psychiat, New York, NY 10003 USA
8.Univ Copenhagen, Hvidovre Hosp, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, DK-1168 Copenhagen, Denmark
9.Max Planck Inst Biol Cybernet, Tubingen, Germany
10.Tech Univ Denmark, Dept Elect Engn, Lyngby, Denmark
11.Columbia Univ Coll Phys & Surg, Dept Neurol Surg, New York, NY 10032 USA
12.Columbia Univ Coll Phys & Surg, Dept Psychiat, 722 W 168th St, New York, NY 10032 USA
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Opitz, Alexander,Falchier, Arnaud,Yan, Chao-Gan,et al. Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates[J]. SCIENTIFIC REPORTS,2016,6(0):1-11.
APA Opitz, Alexander.,Falchier, Arnaud.,Yan, Chao-Gan.,Yeagle, Erin M..,Linn, Gary S..,...&Charles E. Schroeder.(2016).Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates.SCIENTIFIC REPORTS,6(0),1-11.
MLA Opitz, Alexander,et al."Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates".SCIENTIFIC REPORTS 6.0(2016):1-11.
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