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Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates
Opitz, Alexander1,2; Falchier, Arnaud1; Yan, Chao-Gan1,3,4; Yeagle, Erin M.5,6; Linn, Gary S.1,7; Megevand, Pierre5,6; Thielscher, Axel8,9,10; Ross, Deborah A.1; Milham, Michael P.1,2; Mehta, Ashesh D.5,6; Schroeder, Charles E.1,11,12; Charles E. Schroeder
2016-08-18
Source PublicationSCIENTIFIC REPORTS
Correspondent Emailaopitz@nki.rfmh.org
ISSN2045-2322
SubtypeArticle
Volume6Issue:0Pages:1-11
AbstractTranscranial electric stimulation (TES) is an emerging technique, developed to non-invasively modulate brain function. However, the spatiotemporal distribution of the intracranial electric fields induced by TES remains poorly understood. In particular, it is unclear how much current actually reaches the brain, and how it distributes across the brain. Lack of this basic information precludes a firm mechanistic understanding of TES effects. In this study we directly measure the spatial and temporal characteristics of the electric field generated by TES using stereotactic EEG (s-EEG) electrode arrays implanted in cebus monkeys and surgical epilepsy patients. We found a small frequency dependent decrease (10%) in magnitudes of TES induced potentials and negligible phase shifts over space. Electric field strengths were strongest in superficial brain regions with maximum values of about 0.5 mV/mm. Our results provide crucial information of the underlying biophysics in TES applications in humans and the optimization and design of TES stimulation protocols. In addition, our findings have broad implications concerning electric field propagation in non-invasive recording techniques such as EEG/MEG.
DOI10.1038/srep31236
Indexed BySCI
Language英语
Funding OrganizationNathan S. Kline Institute for Psychiatric Research (NKI) ; Child Mind Institute(1FD2013-1) ; Lundbeck foundation(R118-A11308 ; NovoNordisk foundation(11413) ; (MH110217) ; R59 A5399)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000381557200001
WOS HeadingsScience & Technology
WOS KeywordALTERNATING-CURRENT STIMULATION ; BRAIN-STIMULATION ; NETWORK ACTIVITY ; MOTOR CORTEX ; EXCITABILITY ; ENTRAINMENT ; FREQUENCIES ; RECIPROCITY ; SPECTRUM ; CURRENTS
Citation statistics
Cited Times:50[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20519
Collection中国科学院行为科学重点实验室
Corresponding AuthorCharles E. Schroeder
Affiliation1.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
2.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA
3.Chinese Acad Sci, Key Lab Behav Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
5.Hofstra Northwell Sch Med, Dept Neurosurg, Manhasset, NY USA
6.Feinstein Inst Med Res, Manhasset, NY USA
7.NYU, Langone Sch Med, Dept Psychiat, New York, NY 10003 USA
8.Univ Copenhagen, Hvidovre Hosp, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, DK-1168 Copenhagen, Denmark
9.Max Planck Inst Biol Cybernet, Tubingen, Germany
10.Tech Univ Denmark, Dept Elect Engn, Lyngby, Denmark
11.Columbia Univ Coll Phys & Surg, Dept Neurol Surg, New York, NY 10032 USA
12.Columbia Univ Coll Phys & Surg, Dept Psychiat, 722 W 168th St, New York, NY 10032 USA
Recommended Citation
GB/T 7714
Opitz, Alexander,Falchier, Arnaud,Yan, Chao-Gan,et al. Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates[J]. SCIENTIFIC REPORTS,2016,6(0):1-11.
APA Opitz, Alexander.,Falchier, Arnaud.,Yan, Chao-Gan.,Yeagle, Erin M..,Linn, Gary S..,...&Charles E. Schroeder.(2016).Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates.SCIENTIFIC REPORTS,6(0),1-11.
MLA Opitz, Alexander,et al."Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates".SCIENTIFIC REPORTS 6.0(2016):1-11.
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