Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults

doi:10.3389/fnagi.2016.00210

	Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults
	Yu, Jing1,2,3 ; Mamerow, Loreen 2; Lei, Xu 1; Fang, Lei 4; Mata, Rui 2,5; Jing Yu
通讯作者邮箱	helen12@swu.edu.cn
摘要	Previous work suggests that aging is associated with changes in risk taking but less is known about their underlying neural basis, such as the potential age differences in the neural processing of value and risk. The goal of the present study was to investigate adult age differences in functional neural responses in a naturalistic risk-taking task. Twenty-six young adults and 27 healthy older adults completed the Balloon Analogue Risk Task while undergoing functional magnetic resonance imaging. Young and older adults showed similar overt risk-taking behavior. Group comparison of neural activity in response to risky vs. control stimuli revealed similar patterns of activation in the bilateral striatum, anterior insula (AI) and ventromedial prefrontal cortex (vmPFC). Group comparison of parametrically modulated activity in response to continued pumping similarly revealed comparable results for both age groups in the AI and, potentially, the striatum, yet differences emerged for regional activity in the vmPFC. At whole brain level, insular, striatal and vmPFC activation was predictive of behavioral risk taking for young but not older adults. The current results are interpreted and discussed as preserved neural tracking of risk and reward in the AI and striatum, respectively, but altered value coding in the vmPFC in the two age groups. The latter finding points toward older adults exhibiting differential vmPFC-related integration and value coding. Furthermore, neural activation holds differential predictive validity for behavioral risk taking in young and older adults.
关键词	aging decision making ventromedial prefrontal cortex anterior insula Balloon Analogue Risk Task
	2016-08-31
语种	英语
DOI	10.3389/fnagi.2016.00210
发表期刊	FRONTIERS IN AGING NEUROSCIENCE
ISSN	1663-4365
卷号	8 期号:0 页码:1-15
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	ANALOG-RISK-TASK ; REWARD PREDICTION ERRORS ; IOWA GAMBLING TASK ; DECISION-MAKING ; INDIVIDUAL-DIFFERENCES ; AGE-DIFFERENCES ; TAKING PROPENSITY ; NEURAL BASIS ; CHOICE ; BRAIN
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS记录号	WOS:000382354300004
资助机构	National Natural Science Foundation of China(31300856 ; Doctoral Fund of the Ministry of Education of China(20130182120013) ; Fundamental Research Funds for the Central Universities(SWU1509421) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2015G05) ; 31571111)
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20534
专题	中国科学院心理健康重点实验室
通讯作者	Jing Yu
作者单位	1.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 2.Univ Basel, Dept Cognit & Decis Sci, Basel, Switzerland 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 4.Southeast Univ, Fac Med, Nanjing, Jiangsu, Peoples R China 5.Max Planck Inst Human Dev, Berlin, Germany
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Yu, Jing,Mamerow, Loreen,Lei, Xu,et al. Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):1-15.
APA	Yu, Jing,Mamerow, Loreen,Lei, Xu,Fang, Lei,Mata, Rui,&Jing Yu.(2016).Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults.FRONTIERS IN AGING NEUROSCIENCE,8(0),1-15.
MLA	Yu, Jing,et al."Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):1-15.

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