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Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults
Yu, Jing1,2,3; Mamerow, Loreen2; Lei, Xu1; Fang, Lei4; Mata, Rui2,5; Jing Yu
2016-08-31
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
Correspondent Emailhelen12@swu.edu.cn
ISSN1663-4365
SubtypeArticle
Volume8Issue:0Pages:1-15
AbstractPrevious work suggests that aging is associated with changes in risk taking but less is known about their underlying neural basis, such as the potential age differences in the neural processing of value and risk. The goal of the present study was to investigate adult age differences in functional neural responses in a naturalistic risk-taking task. Twenty-six young adults and 27 healthy older adults completed the Balloon Analogue Risk Task while undergoing functional magnetic resonance imaging. Young and older adults showed similar overt risk-taking behavior. Group comparison of neural activity in response to risky vs. control stimuli revealed similar patterns of activation in the bilateral striatum, anterior insula (AI) and ventromedial prefrontal cortex (vmPFC). Group comparison of parametrically modulated activity in response to continued pumping similarly revealed comparable results for both age groups in the AI and, potentially, the striatum, yet differences emerged for regional activity in the vmPFC. At whole brain level, insular, striatal and vmPFC activation was predictive of behavioral risk taking for young but not older adults. The current results are interpreted and discussed as preserved neural tracking of risk and reward in the AI and striatum, respectively, but altered value coding in the vmPFC in the two age groups. The latter finding points toward older adults exhibiting differential vmPFC-related integration and value coding. Furthermore, neural activation holds differential predictive validity for behavioral risk taking in young and older adults.
Keywordaging decision making ventromedial prefrontal cortex anterior insula Balloon Analogue Risk Task
DOI10.3389/fnagi.2016.00210
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31300856 ; Doctoral Fund of the Ministry of Education of China(20130182120013) ; Fundamental Research Funds for the Central Universities(SWU1509421) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2015G05) ; 31571111)
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000382354300004
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordANALOG-RISK-TASK ; REWARD PREDICTION ERRORS ; IOWA GAMBLING TASK ; DECISION-MAKING ; INDIVIDUAL-DIFFERENCES ; AGE-DIFFERENCES ; TAKING PROPENSITY ; NEURAL BASIS ; CHOICE ; BRAIN
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20534
Collection中国科学院心理健康重点实验室
Corresponding AuthorJing Yu
Affiliation1.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
2.Univ Basel, Dept Cognit & Decis Sci, Basel, Switzerland
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
4.Southeast Univ, Fac Med, Nanjing, Jiangsu, Peoples R China
5.Max Planck Inst Human Dev, Berlin, Germany
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Yu, Jing,Mamerow, Loreen,Lei, Xu,et al. Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):1-15.
APA Yu, Jing,Mamerow, Loreen,Lei, Xu,Fang, Lei,Mata, Rui,&Jing Yu.(2016).Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults.FRONTIERS IN AGING NEUROSCIENCE,8(0),1-15.
MLA Yu, Jing,et al."Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):1-15.
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