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Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence
Li, Man1; Du, Wei1; Shao, Feng1; Wang, Weiwen2
2016-10-15
发表期刊BEHAVIOURAL BRAIN RESEARCH
通讯作者邮箱shaof@pku.edu.cn ; wangww@psych.ac.cn
ISSN0166-4328
文章类型Article
卷号313期号:0页码:177-183
摘要Early life adversity, such as social isolation, causes a variety of changes to the development of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic modifications mediate gene-environment interactions throughout the lifespan. In this study, we investigated the effect of adolescent social isolation on cognitive behaviours and epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene. Male Sprague Dawley rats were randomly assigned to either group reared or isolation-reared conditions during post-natal days (PNDs) 21-34. On PND 56, all rats underwent behavioural testing and were then sacrificed for biochemical testing. Adolescent social isolation induced impaired PPI. Regarding BDNF, the isolation-reared rats demonstrated increased BDNF mRNA levels, H3 acetylation at the BDNF gene and BDNF protein expression in the medial prefrontal cortex (mPFC). In contrast, the BDNF mRNA levels, H3 acetylation of the BDNF gene and BDNF protein expression were decreased in the hippocampus of the isolation-reared rats. The present study indicated that epigenetic regulation of BDNF may be one of the molecular mechanisms that mediated the cognitive dysfunction. Moreover, the interaction between the mPFC and hippocampus might play an important role in the regulation of cognitive behaviour. (C) 2016 Elsevier B.V. All rights reserved.
关键词Social Isolation Cognitive Behaviour Brain-derived Neurotrophic Factor (Bdnf) Epigenetics
DOI10.1016/j.bbr.2016.07.025
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31470988 ; School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, the Chinese Academy of Sciences(KJZD-EW-L04) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 81471122)
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000382413800021
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MEDIAL PREFRONTAL CORTEX ; NEUROTROPHIC FACTOR EXPRESSION ; SPATIAL MEMORY PERFORMANCE ; ACOUSTIC STARTLE RESPONSE ; PREPULSE INHIBITION ; ADULT RATS ; MATERNAL SEPARATION ; VENTRAL HIPPOCAMPUS ; THETA-OSCILLATIONS ; NUCLEUS-ACCUMBENS
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20535
专题中国科学院心理健康重点实验室
通讯作者Shao, Feng; Wang, Weiwen
作者单位1.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
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GB/T 7714
Li, Man,Du, Wei,Shao, Feng,et al. Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence[J]. BEHAVIOURAL BRAIN RESEARCH,2016,313(0):177-183.
APA Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2016).Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence.BEHAVIOURAL BRAIN RESEARCH,313(0),177-183.
MLA Li, Man,et al."Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence".BEHAVIOURAL BRAIN RESEARCH 313.0(2016):177-183.
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