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Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence
Li, Man1; Du, Wei1; Shao, Feng1; Wang, Weiwen2
2016-10-15
Source PublicationBEHAVIOURAL BRAIN RESEARCH
Correspondent Emailshaof@pku.edu.cn ; wangww@psych.ac.cn
ISSN0166-4328
SubtypeArticle
Volume313Issue:0Pages:177-183
AbstractEarly life adversity, such as social isolation, causes a variety of changes to the development of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic modifications mediate gene-environment interactions throughout the lifespan. In this study, we investigated the effect of adolescent social isolation on cognitive behaviours and epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene. Male Sprague Dawley rats were randomly assigned to either group reared or isolation-reared conditions during post-natal days (PNDs) 21-34. On PND 56, all rats underwent behavioural testing and were then sacrificed for biochemical testing. Adolescent social isolation induced impaired PPI. Regarding BDNF, the isolation-reared rats demonstrated increased BDNF mRNA levels, H3 acetylation at the BDNF gene and BDNF protein expression in the medial prefrontal cortex (mPFC). In contrast, the BDNF mRNA levels, H3 acetylation of the BDNF gene and BDNF protein expression were decreased in the hippocampus of the isolation-reared rats. The present study indicated that epigenetic regulation of BDNF may be one of the molecular mechanisms that mediated the cognitive dysfunction. Moreover, the interaction between the mPFC and hippocampus might play an important role in the regulation of cognitive behaviour. (C) 2016 Elsevier B.V. All rights reserved.
KeywordSocial Isolation Cognitive Behaviour Brain-derived Neurotrophic Factor (Bdnf) Epigenetics
DOI10.1016/j.bbr.2016.07.025
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31470988 ; School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, the Chinese Academy of Sciences(KJZD-EW-L04) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 81471122)
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000382413800021
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMEDIAL PREFRONTAL CORTEX ; NEUROTROPHIC FACTOR EXPRESSION ; SPATIAL MEMORY PERFORMANCE ; ACOUSTIC STARTLE RESPONSE ; PREPULSE INHIBITION ; ADULT RATS ; MATERNAL SEPARATION ; VENTRAL HIPPOCAMPUS ; THETA-OSCILLATIONS ; NUCLEUS-ACCUMBENS
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Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20535
Collection中国科学院心理健康重点实验室
Corresponding AuthorShao, Feng; Wang, Weiwen
Affiliation1.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Man,Du, Wei,Shao, Feng,et al. Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence[J]. BEHAVIOURAL BRAIN RESEARCH,2016,313(0):177-183.
APA Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2016).Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence.BEHAVIOURAL BRAIN RESEARCH,313(0),177-183.
MLA Li, Man,et al."Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence".BEHAVIOURAL BRAIN RESEARCH 313.0(2016):177-183.
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