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A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
Wu, Xia1,2; Li, Qing1; Yu, Xinyu1; Chen, Kewei3,4; Fleisher, Adam S.3,4,5; Guo, Xiaojuan1; Zhang, Jiacai1; Reiman, Eric M.3,4; Yao, Li1,2; Li, Rui6
2016-09-28
发表期刊FRONTIERS IN AGING NEUROSCIENCE
通讯作者邮箱lir@psych.ac.cn
ISSN1663-4365
文章类型Article
卷号8期号:0页码:1-9
摘要The triple network model, consisting of the central executive network (CEN), salience network (SN) and default mode network (DMN), has been recently employed to understand dysfunction in core networks across various disorders. Here we used the triple network model to investigate the large-scale brain networks in cognitively normal apolipoprotein e4 (APOE4) carriers who are at risk of Alzheimers disease (AD). To explore the functional connectivity for each of the three networks and the effective connectivity among them, we evaluated 17 cognitively normal individuals with a family history of AD and at least one copy of the APOE4 allele and compared the findings to those of 12 individuals who did not carry the APOE4 gene or have a family history of AD, using independent component analysis (ICA) and Bayesian network (BN) approach. Our findings indicated altered within-network connectivity that suggests future cognitive decline risk, and preserved between-network connectivity that may support their current preserved cognition in the cognitively normal APOE4 allele carriers. The study provides novel sights into our understanding of the risk factors for AD and their influence on the triple network model of major psychopathology.
关键词Alzheimer's Disease APOE4 Bayesian network connectivity fMRI triple network model
DOI10.3389/fnagi.2016.00231
收录类别SCI
语种英语
项目资助者National Institute on Aging(k23 AG024062) ; Funds for International Cooperation and Exchange of the National Natural Science Foundation of China(61210001) ; General Program of National Natural Science Foundation of China(61571047 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZG03 ; 31200847) ; KLMH2015G06)
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:000384137400001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]DEFAULT-MODE NETWORK ; INDEPENDENT COMPONENT ANALYSIS ; RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; FRONTOTEMPORAL DEMENTIA ; IMPAIRMENT ; MEMORY ; RISK ; MRI
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20541
专题中国科学院心理健康重点实验室
通讯作者Li, Rui
作者单位1.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
3.Banner Alzheimers Inst, Phoenix, AZ USA
4.Banner Good Samaritan PET Ctr, Phoenix, AZ USA
5.Eli Lilly & Co, Indianapolis, IN 46285 USA
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China
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GB/T 7714
Wu, Xia,Li, Qing,Yu, Xinyu,et al. A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):1-9.
APA Wu, Xia.,Li, Qing.,Yu, Xinyu.,Chen, Kewei.,Fleisher, Adam S..,...&Li, Rui.(2016).A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers.FRONTIERS IN AGING NEUROSCIENCE,8(0),1-9.
MLA Wu, Xia,et al."A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):1-9.
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