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A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
Wu, Xia1,2; Li, Qing1; Yu, Xinyu1; Chen, Kewei3,4; Fleisher, Adam S.3,4,5; Guo, Xiaojuan1; Zhang, Jiacai1; Reiman, Eric M.3,4; Yao, Li1,2; Li, Rui6
2016-09-28
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
Correspondent Emaillir@psych.ac.cn
ISSN1663-4365
SubtypeArticle
Volume8Issue:0Pages:1-9
AbstractThe triple network model, consisting of the central executive network (CEN), salience network (SN) and default mode network (DMN), has been recently employed to understand dysfunction in core networks across various disorders. Here we used the triple network model to investigate the large-scale brain networks in cognitively normal apolipoprotein e4 (APOE4) carriers who are at risk of Alzheimers disease (AD). To explore the functional connectivity for each of the three networks and the effective connectivity among them, we evaluated 17 cognitively normal individuals with a family history of AD and at least one copy of the APOE4 allele and compared the findings to those of 12 individuals who did not carry the APOE4 gene or have a family history of AD, using independent component analysis (ICA) and Bayesian network (BN) approach. Our findings indicated altered within-network connectivity that suggests future cognitive decline risk, and preserved between-network connectivity that may support their current preserved cognition in the cognitively normal APOE4 allele carriers. The study provides novel sights into our understanding of the risk factors for AD and their influence on the triple network model of major psychopathology.
KeywordAlzheimer's Disease APOE4 Bayesian network connectivity fMRI triple network model
DOI10.3389/fnagi.2016.00231
Indexed BySCI
Language英语
Funding OrganizationNational Institute on Aging(k23 AG024062) ; Funds for International Cooperation and Exchange of the National Natural Science Foundation of China(61210001) ; General Program of National Natural Science Foundation of China(61571047 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZG03 ; 31200847) ; KLMH2015G06)
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000384137400001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDEFAULT-MODE NETWORK ; INDEPENDENT COMPONENT ANALYSIS ; RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; FRONTOTEMPORAL DEMENTIA ; IMPAIRMENT ; MEMORY ; RISK ; MRI
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20541
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Rui
Affiliation1.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
3.Banner Alzheimers Inst, Phoenix, AZ USA
4.Banner Good Samaritan PET Ctr, Phoenix, AZ USA
5.Eli Lilly & Co, Indianapolis, IN 46285 USA
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wu, Xia,Li, Qing,Yu, Xinyu,et al. A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):1-9.
APA Wu, Xia.,Li, Qing.,Yu, Xinyu.,Chen, Kewei.,Fleisher, Adam S..,...&Li, Rui.(2016).A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers.FRONTIERS IN AGING NEUROSCIENCE,8(0),1-9.
MLA Wu, Xia,et al."A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):1-9.
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