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Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats
Wang, Ning1; Li, Sheng-Guang1; Lin, Xiao-Xiao1,2; Su, Yuan-Lin1; Qi, Wei-Jing1; Wang, Jin-Yan1,2; Luo, Fei1,2
2016-09-28
发表期刊FRONTIERS IN BEHAVIORAL NEUROSCIENCE
通讯作者邮箱wangjy@psych.ac.cn
ISSN1662-5153
文章类型Article
卷号10期号:0页码:1-12
摘要Although previous studies have suggested that depression may be associated with inhibition of evoked pain but facilitation of spontaneous pain, the mechanisms underlying these relationships are unclear. The present study investigated whether the difference between evoked and spontaneous pain on sensory (descending inhibition) and affective (avoidance motivation) components contributes to the divergent effects of depression on them. Depressive-like behavior was produced in male Wistar rats by unpredictable chronic mild stress (UCMS). Tone-laser conditioning and formalin-induced conditioned place avoidance (F-CPA) were used to explore avoidance motivation in evoked and spontaneous pain, respectively. Behavioral pharmacology experiments were conducted to examine descending inhibition of both evoked (thermal stimulation) and spontaneous pain behavior (formalin pain). The results revealed that the inhibitory effect of depression on evoked pain was eliminated following repeated thermal stimuli. Avoidance behavior in the tone-laser conditioning task was reduced in UCMS rats, relative to controls. However, avoidance motivation for formalin pain in the UCMS group was similar to controls. 5-HT1A receptor antagonism interfered with inhibition of pain responses over time. The present study demonstrated that the inhibitory effect of depression on evoked pain dissipates with increased nociception and that the sensory-discriminative and affective-motivational components of pain are jointly involved in the divergent effects of depression on pain.
关键词unpredictable chronic mild stress pain serotonin descending inhibition avoidance motivation
DOI10.3389/fnbeh.2016.00183
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China (NSFC)(31271092) ; Youth Innovation Promotion Association CAS grant ; NSFC(61033011 ; Key Laboratory of Mental health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZK01 ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences(Y4CX111005) ; 31171067 ; KLMH2014ZG05) ; 31471061 ; 81100828 ; 31671140)
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000384048600002
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ANTERIOR CINGULATE CORTEX ; FRONTAL EEG ASYMMETRY ; CUTANEOUS HYPERALGESIA ; BEHAVIORAL ACTIVATION ; AFFECTIVE COMPONENT ; MAJOR DEPRESSION ; SEROTONIN SYSTEM ; AVOIDANCE GOALS ; MILD STRESS ; PERCEPTION
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20543
专题中国科学院心理健康重点实验室
通讯作者Wang, Jin-Yan
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
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Wang, Ning,Li, Sheng-Guang,Lin, Xiao-Xiao,et al. Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2016,10(0):1-12.
APA Wang, Ning.,Li, Sheng-Guang.,Lin, Xiao-Xiao.,Su, Yuan-Lin.,Qi, Wei-Jing.,...&Luo, Fei.(2016).Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,10(0),1-12.
MLA Wang, Ning,et al."Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 10.0(2016):1-12.
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