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Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats
Wang, Ning1; Li, Sheng-Guang1; Lin, Xiao-Xiao1,2; Su, Yuan-Lin1; Qi, Wei-Jing1; Wang, Jin-Yan1,2; Luo, Fei1,2
2016-09-28
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
Correspondent Emailwangjy@psych.ac.cn
ISSN1662-5153
SubtypeArticle
Volume10Issue:0Pages:1-12
AbstractAlthough previous studies have suggested that depression may be associated with inhibition of evoked pain but facilitation of spontaneous pain, the mechanisms underlying these relationships are unclear. The present study investigated whether the difference between evoked and spontaneous pain on sensory (descending inhibition) and affective (avoidance motivation) components contributes to the divergent effects of depression on them. Depressive-like behavior was produced in male Wistar rats by unpredictable chronic mild stress (UCMS). Tone-laser conditioning and formalin-induced conditioned place avoidance (F-CPA) were used to explore avoidance motivation in evoked and spontaneous pain, respectively. Behavioral pharmacology experiments were conducted to examine descending inhibition of both evoked (thermal stimulation) and spontaneous pain behavior (formalin pain). The results revealed that the inhibitory effect of depression on evoked pain was eliminated following repeated thermal stimuli. Avoidance behavior in the tone-laser conditioning task was reduced in UCMS rats, relative to controls. However, avoidance motivation for formalin pain in the UCMS group was similar to controls. 5-HT1A receptor antagonism interfered with inhibition of pain responses over time. The present study demonstrated that the inhibitory effect of depression on evoked pain dissipates with increased nociception and that the sensory-discriminative and affective-motivational components of pain are jointly involved in the divergent effects of depression on pain.
Keywordunpredictable chronic mild stress pain serotonin descending inhibition avoidance motivation
DOI10.3389/fnbeh.2016.00183
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China (NSFC)(31271092) ; Youth Innovation Promotion Association CAS grant ; NSFC(61033011 ; Key Laboratory of Mental health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZK01 ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences(Y4CX111005) ; 31171067 ; KLMH2014ZG05) ; 31471061 ; 81100828 ; 31671140)
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000384048600002
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordANTERIOR CINGULATE CORTEX ; FRONTAL EEG ASYMMETRY ; CUTANEOUS HYPERALGESIA ; BEHAVIORAL ACTIVATION ; AFFECTIVE COMPONENT ; MAJOR DEPRESSION ; SEROTONIN SYSTEM ; AVOIDANCE GOALS ; MILD STRESS ; PERCEPTION
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20543
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Jin-Yan
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Ning,Li, Sheng-Guang,Lin, Xiao-Xiao,et al. Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2016,10(0):1-12.
APA Wang, Ning.,Li, Sheng-Guang.,Lin, Xiao-Xiao.,Su, Yuan-Lin.,Qi, Wei-Jing.,...&Luo, Fei.(2016).Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,10(0),1-12.
MLA Wang, Ning,et al."Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 10.0(2016):1-12.
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