Upregulation of K+ Current in Hippocampal Neurons from Rat with Depressive-Like Behavior Induced by Lipopolysaccharide Abstract Shao-Peng Chi Directed by Dr. Wenjuan Lin Institute of Psychology, Chinese Academy of Sciences Depression is one of the most disabling mental diseases with unknown pathogenesis. The aim of the present study was to investigate the association between lipopolysaccharide-induced depressive-like behavior in rats and the voltage--dependent potassium channel currents of hippocampal neurons as well as the potassium channel-mediated hippocampal neuronal apoptosis. The behavioral paradigm used was the peripherally administration of LPS induced depressive-like behavior. The animal behaviors were assessed by the saccharin preference test and open field test. The whole-cell potassium currents in hippocampal neurons were measured using the patch clamp voltage clamp technique. The action potentials were measured using the current-clamp technique. The cell apoptosis was compared between hippocampal neurons isolated from LPS-treated and control mice by using DAPI staining.
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