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The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia
Li, Xu1,2,3; Li, Zhi1,2; Li, Ke4; Zeng, Ya-wei4; Shi, Hai-song1,2,5; Xie, Wen-lan1,2; Yang, Zhuo-ya1,2; Lui, Simon S. Y.1,2,6; Cheung, Eric F. C.6; Leung, Ada W. S.7,8; Chan, Raymond C. K.1,2
2016-10-18
发表期刊SCIENTIFIC REPORTS
通讯作者邮箱rckchan@psych.ac.cn
ISSN2045-2322
文章类型Article
卷号6期号:0页码:1-10
摘要Anhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy. Deficits in hedonic processing have been postulated to be related to decreased motivation to engage in potentially rewarding events. It remains unclear whether non-pharmacological interventions, such as cognitive training, could improve anhedonia. The present study aimed to examine the neural mechanism for alleviating hedonic deficits with working memory ( WM) training in individuals with social anhedonia. Fifteen individuals with social anhedonia were recruited and received 20 sessions of training on a dual n-back task, five sessions a week. Functional imaging paradigms of the Monetary Incentive Delay ( MID) and the Affective Incentive Delay ( AID) tasks were administered both before and after the training to evaluate the neural transfer effects on hedonic processing ability. Enhanced brain activations related to anticipation were observed at the anterior cingulate cortex, the left dorsal striatum and the left precuneus with the AID task, and at the dorsolateral prefrontal cortex and the supramarginal gyrus with the MID task. The present findings support that WM training may improve monetary-based and affective-based hedonic processing in individuals with social anhedonia.
DOI10.1038/srep35481
收录类别SCI ; SSCI
语种英语
项目资助者Chinese Academy of Sciences(XDB02030002) ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; National Natural Science Fund China(91132701 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; CAS/SAFEA International Partnership Programme for Creative Research Teams(Y2CX131003) ; 81571317)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000385586900001
WOS标题词Science & Technology
关键词[WOS]COGNITIVE REMEDIATION THERAPY ; EMOTIONAL EXPRESSIVITY SCALE ; MAJOR DEPRESSIVE DISORDER ; NUCLEUS-ACCUMBENS ; SCHIZOPHRENIA ; BRAIN ; FMRI ; METAANALYSIS ; MONETARY ; REWARDS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20690
专题中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100048, Peoples R China
3.Cent China Normal Univ, Sch Psychol, Key Lab Adolescent Cyberpsychol & Behav CCNU, Minist Educ, Wuhan 430079, Peoples R China
4.Hosp 306, MRI Ctr, Beijing 100101, Peoples R China
5.North China Elect Power Univ, Beijing 102206, Peoples R China
6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
7.Univ Alberta, Dept Occupat Therapy, Edmonton, AB T6G 2G4, Canada
8.Univ Alberta, Inst Neurosci & Mental Hlth, Edmonton, AB T6G 2G4, Canada
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GB/T 7714
Li, Xu,Li, Zhi,Li, Ke,et al. The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia[J]. SCIENTIFIC REPORTS,2016,6(0):1-10.
APA Li, Xu.,Li, Zhi.,Li, Ke.,Zeng, Ya-wei.,Shi, Hai-song.,...&Chan, Raymond C. K..(2016).The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia.SCIENTIFIC REPORTS,6(0),1-10.
MLA Li, Xu,et al."The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia".SCIENTIFIC REPORTS 6.0(2016):1-10.
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