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The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia
Li, Xu1,2,3; Li, Zhi1,2; Li, Ke4; Zeng, Ya-wei4; Shi, Hai-song1,2,5; Xie, Wen-lan1,2; Yang, Zhuo-ya1,2; Lui, Simon S. Y.1,2,6; Cheung, Eric F. C.6; Leung, Ada W. S.7,8; Chan, Raymond C. K.1,2
Correspondent Emailrckchan@psych.ac.cn
AbstractAnhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy. Deficits in hedonic processing have been postulated to be related to decreased motivation to engage in potentially rewarding events. It remains unclear whether non-pharmacological interventions, such as cognitive training, could improve anhedonia. The present study aimed to examine the neural mechanism for alleviating hedonic deficits with working memory ( WM) training in individuals with social anhedonia. Fifteen individuals with social anhedonia were recruited and received 20 sessions of training on a dual n-back task, five sessions a week. Functional imaging paradigms of the Monetary Incentive Delay ( MID) and the Affective Incentive Delay ( AID) tasks were administered both before and after the training to evaluate the neural transfer effects on hedonic processing ability. Enhanced brain activations related to anticipation were observed at the anterior cingulate cortex, the left dorsal striatum and the left precuneus with the AID task, and at the dorsolateral prefrontal cortex and the supramarginal gyrus with the MID task. The present findings support that WM training may improve monetary-based and affective-based hedonic processing in individuals with social anhedonia.
2016-10-18
Language英语
DOI10.1038/srep35481
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6Issue:0Pages:1-10
SubtypeArticle
Indexed BySCI ; SSCI
WOS KeywordCOGNITIVE REMEDIATION THERAPY ; EMOTIONAL EXPRESSIVITY SCALE ; MAJOR DEPRESSIVE DISORDER ; NUCLEUS-ACCUMBENS ; SCHIZOPHRENIA ; BRAIN ; FMRI ; METAANALYSIS ; MONETARY ; REWARDS
WOS HeadingsScience & Technology
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000385586900001
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20690
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100048, Peoples R China
3.Cent China Normal Univ, Sch Psychol, Key Lab Adolescent Cyberpsychol & Behav CCNU, Minist Educ, Wuhan 430079, Peoples R China
4.Hosp 306, MRI Ctr, Beijing 100101, Peoples R China
5.North China Elect Power Univ, Beijing 102206, Peoples R China
6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
7.Univ Alberta, Dept Occupat Therapy, Edmonton, AB T6G 2G4, Canada
8.Univ Alberta, Inst Neurosci & Mental Hlth, Edmonton, AB T6G 2G4, Canada
Recommended Citation
GB/T 7714
Li, Xu,Li, Zhi,Li, Ke,et al. The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia[J]. SCIENTIFIC REPORTS,2016,6(0):1-10.
APA Li, Xu.,Li, Zhi.,Li, Ke.,Zeng, Ya-wei.,Shi, Hai-song.,...&Chan, Raymond C. K..(2016).The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia.SCIENTIFIC REPORTS,6(0),1-10.
MLA Li, Xu,et al."The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia".SCIENTIFIC REPORTS 6.0(2016):1-10.
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