Alzheimer's disease and gut microbiota

doi:10.1007/s11427-016-5083-9

	Alzheimer's disease and gut microbiota
	Hu, Xu; Wang, Tao; Jin, Feng
摘要	Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrier induced by gut microbiota disturbance will increase the incidence of neurodegeneration disorders. Gut microbial metabolites and their effects on host neurochemical changes may increase or decrease the risk of AD. Pathogenic microbes infection will also increase the risk of AD, and meanwhile, the onset of AD support the "hygiene hypothesis". All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for AD.
关键词	Alzheimer's disease gut microbiota leaky gut leaky brain diet infection hygiene hypothesis
	2016-10-01
语种	英语
DOI	10.1007/s11427-016-5083-9
发表期刊	SCIENCE CHINA-LIFE SCIENCES
ISSN	1674-7305
卷号	59 期号:10 页码:1006-1023
期刊论文类型	Review
收录类别	SCI
WOS关键词	AMYOTROPHIC-LATERAL-SCLEROSIS ; SIMPLEX-VIRUS TYPE-1 ; BLOOD-BRAIN-BARRIER ; HELICOBACTER-PYLORI INFECTION ; MILD COGNITIVE IMPAIRMENT ; POPULATION-BASED CAIDE ; METHYLAMINO-L-ALANINE ; AMYLOID-BETA-PEPTIDE ; HYGIENE HYPOTHESIS ; CALORIC RESTRICTION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000385416200004
资助机构	NS Bio Japan ; NS Bio Guangzhou
引用统计	被引频次：247[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20693
专题	中国科学院心理健康重点实验室
作者单位	Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Hu, Xu,Wang, Tao,Jin, Feng. Alzheimer's disease and gut microbiota[J]. SCIENCE CHINA-LIFE SCIENCES,2016,59(10):1006-1023.
APA	Hu, Xu,Wang, Tao,&Jin, Feng.(2016).Alzheimer's disease and gut microbiota.SCIENCE CHINA-LIFE SCIENCES,59(10),1006-1023.
MLA	Hu, Xu,et al."Alzheimer's disease and gut microbiota".SCIENCE CHINA-LIFE SCIENCES 59.10(2016):1006-1023.

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