PSYCH OpenIR  > 中国科学院心理健康重点实验室
Alzheimer's disease and gut microbiota
Hu, Xu; Wang, Tao; Jin, Feng
2016-10-01
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
SubtypeReview
Volume59Issue:10Pages:1006-1023
AbstractAlzheimer's disease (AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrier induced by gut microbiota disturbance will increase the incidence of neurodegeneration disorders. Gut microbial metabolites and their effects on host neurochemical changes may increase or decrease the risk of AD. Pathogenic microbes infection will also increase the risk of AD, and meanwhile, the onset of AD support the "hygiene hypothesis". All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for AD.
KeywordAlzheimer's disease gut microbiota leaky gut leaky brain diet infection hygiene hypothesis
DOI10.1007/s11427-016-5083-9
Indexed BySCI
Language英语
Funding OrganizationNS Bio Japan ; NS Bio Guangzhou
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000385416200004
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordAMYOTROPHIC-LATERAL-SCLEROSIS ; SIMPLEX-VIRUS TYPE-1 ; BLOOD-BRAIN-BARRIER ; HELICOBACTER-PYLORI INFECTION ; MILD COGNITIVE IMPAIRMENT ; POPULATION-BASED CAIDE ; METHYLAMINO-L-ALANINE ; AMYLOID-BETA-PEPTIDE ; HYGIENE HYPOTHESIS ; CALORIC RESTRICTION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20693
Collection中国科学院心理健康重点实验室
AffiliationChinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Hu, Xu,Wang, Tao,Jin, Feng. Alzheimer's disease and gut microbiota[J]. SCIENCE CHINA-LIFE SCIENCES,2016,59(10):1006-1023.
APA Hu, Xu,Wang, Tao,&Jin, Feng.(2016).Alzheimer's disease and gut microbiota.SCIENCE CHINA-LIFE SCIENCES,59(10),1006-1023.
MLA Hu, Xu,et al."Alzheimer's disease and gut microbiota".SCIENCE CHINA-LIFE SCIENCES 59.10(2016):1006-1023.
Files in This Item:
File Name/Size DocType Version Access License
Alzheimer's disease (547KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu, Xu]'s Articles
[Wang, Tao]'s Articles
[Jin, Feng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu, Xu]'s Articles
[Wang, Tao]'s Articles
[Jin, Feng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu, Xu]'s Articles
[Wang, Tao]'s Articles
[Jin, Feng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Alzheimer's disease and gut microbiota.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.