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Alzheimer's disease and gut microbiota
Hu, Xu; Wang, Tao; Jin, Feng
2016-10-01
发表期刊SCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
文章类型Review
卷号59期号:10页码:1006-1023
摘要Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrier induced by gut microbiota disturbance will increase the incidence of neurodegeneration disorders. Gut microbial metabolites and their effects on host neurochemical changes may increase or decrease the risk of AD. Pathogenic microbes infection will also increase the risk of AD, and meanwhile, the onset of AD support the "hygiene hypothesis". All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for AD.
关键词Alzheimer's disease gut microbiota leaky gut leaky brain diet infection hygiene hypothesis
DOI10.1007/s11427-016-5083-9
收录类别SCI
语种英语
项目资助者NS Bio Japan ; NS Bio Guangzhou
WOS研究方向Life Sciences & Biomedicine - Other Topics
WOS类目Biology
WOS记录号WOS:000385416200004
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]AMYOTROPHIC-LATERAL-SCLEROSIS ; SIMPLEX-VIRUS TYPE-1 ; BLOOD-BRAIN-BARRIER ; HELICOBACTER-PYLORI INFECTION ; MILD COGNITIVE IMPAIRMENT ; POPULATION-BASED CAIDE ; METHYLAMINO-L-ALANINE ; AMYLOID-BETA-PEPTIDE ; HYGIENE HYPOTHESIS ; CALORIC RESTRICTION
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20693
专题中国科学院心理健康重点实验室
作者单位Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Hu, Xu,Wang, Tao,Jin, Feng. Alzheimer's disease and gut microbiota[J]. SCIENCE CHINA-LIFE SCIENCES,2016,59(10):1006-1023.
APA Hu, Xu,Wang, Tao,&Jin, Feng.(2016).Alzheimer's disease and gut microbiota.SCIENCE CHINA-LIFE SCIENCES,59(10),1006-1023.
MLA Hu, Xu,et al."Alzheimer's disease and gut microbiota".SCIENCE CHINA-LIFE SCIENCES 59.10(2016):1006-1023.
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