Institutional Repository of Key Laboratory of Mental Health, CAS
Mild Cognitive Impairment Is Not "Mild" at All in Altered Activation of Episodic Memory Brain Networks: Evidence from ALE Meta-Analysis | |
Wang, Pengyun1; Li, Juan1; Li, Hui-Jie2; Huo, Lijuan1,3; Li, Rui1; Juan Li | |
第一作者 | Wang, Pengyun |
通讯作者邮箱 | lijuan@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | The present study conducted a quantitative meta-analysis aiming at assessing consensus across the functional neuroimaging studies of episodic memory in individuals with amnestic mild cognitive impairment (aMCI) and elucidating consistent activation patterns. An activation likelihood estimation (ALE) was conducted on the functional neuroimaging studies of episodic encoding and retrieval in aMCI individuals published up to March 31, 2015. Analyses covered 24 studies, which yielded 770 distinct foci. Compared to healthy controls, aMCI individuals showed statistically significant consistent activation differences in a widespread episodic memory network, not only in the bilateral medial temporal lobe and prefrontal cortex, but also in the angular gyrus, precunes, posterior cingulate cortex, and even certain more basic structures. The present ALE meta-analysis revealed that the abnormal patterns of widespread episodic memory network indicated that individuals with aMCI may not be completely "mild" in nature. |
关键词 | mild cognitive impairment episodic memory encoding retrieval activation likelihood estimation |
2016-11-07 | |
语种 | 英语 |
DOI | 10.3389/fnagi.2016.00260 |
发表期刊 | FRONTIERS IN AGING NEUROSCIENCE |
ISSN | 1663-4365 |
卷号 | 8期号:0页码:1-16 |
期刊论文类型 | Article |
URL | 查看原文 |
收录类别 | SCI ; SSCI |
WOS关键词 | MEDIAL TEMPORAL-LOBE ; DEFAULT MODE NETWORK ; DORSOLATERAL PREFRONTAL CORTEX ; RESONANCE-IMAGING CHANGES ; HEALTHY OLDER-ADULTS ; ALZHEIMERS-DISEASE ; PARIETAL CORTEX ; HIPPOCAMPAL ACTIVATION ; RECOGNITION MEMORY ; FUNCTIONAL CONNECTIVITY |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
WOS类目 | Geriatrics & Gerontology ; Neurosciences |
WOS记录号 | WOS:000386956400001 |
Q分类 | Q1 |
资助机构 | National Natural Science Foundation of China(31271108 ; National Science and Technology Pillar Program of China(2009BAI77B03) ; Knowledge Innovation Project of the Chinese Academy of Sciences(KSCX2-EW-J-8) ; CAS/SAFEA International Partnership Program for Creative Research Team(Y2CX131003) ; Institute of psychology, Chinese Academy of Sciences(1110000038 ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program(TSS-2015-06) ; CAS Key Laboratory of Mental Health, Institute of Psychology(KLMH2014ZK02 ; 30911120494 ; Y3CX151005) ; KLMH2014ZG10) ; 31070916 ; 31671157 ; 31400895) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/20708 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Juan Li |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Lab Funct Connectome & Dev, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Wang, Pengyun,Li, Juan,Li, Hui-Jie,et al. Mild Cognitive Impairment Is Not "Mild" at All in Altered Activation of Episodic Memory Brain Networks: Evidence from ALE Meta-Analysis[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):1-16. |
APA | Wang, Pengyun,Li, Juan,Li, Hui-Jie,Huo, Lijuan,Li, Rui,&Juan Li.(2016).Mild Cognitive Impairment Is Not "Mild" at All in Altered Activation of Episodic Memory Brain Networks: Evidence from ALE Meta-Analysis.FRONTIERS IN AGING NEUROSCIENCE,8(0),1-16. |
MLA | Wang, Pengyun,et al."Mild Cognitive Impairment Is Not "Mild" at All in Altered Activation of Episodic Memory Brain Networks: Evidence from ALE Meta-Analysis".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):1-16. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
fnagi-08-00260.pdf(1226KB) | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论