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Mild Cognitive Impairment Is Not "Mild" at All in Altered Activation of Episodic Memory Brain Networks: Evidence from ALE Meta-Analysis
Wang, Pengyun1; Li, Juan1; Li, Hui-Jie2; Huo, Lijuan1,3; Li, Rui1; Juan Li
第一作者Wang, Pengyun
2016-11-07
发表期刊FRONTIERS IN AGING NEUROSCIENCE
通讯作者邮箱lijuan@psych.ac.cn
ISSN1663-4365
文章类型Article
卷号8期号:0页码:1-16
Q分类Q1
产权排序1
摘要

The present study conducted a quantitative meta-analysis aiming at assessing consensus across the functional neuroimaging studies of episodic memory in individuals with amnestic mild cognitive impairment (aMCI) and elucidating consistent activation patterns. An activation likelihood estimation (ALE) was conducted on the functional neuroimaging studies of episodic encoding and retrieval in aMCI individuals published up to March 31, 2015. Analyses covered 24 studies, which yielded 770 distinct foci. Compared to healthy controls, aMCI individuals showed statistically significant consistent activation differences in a widespread episodic memory network, not only in the bilateral medial temporal lobe and prefrontal cortex, but also in the angular gyrus, precunes, posterior cingulate cortex, and even certain more basic structures. The present ALE meta-analysis revealed that the abnormal patterns of widespread episodic memory network indicated that individuals with aMCI may not be completely "mild" in nature.

关键词mild cognitive impairment episodic memory encoding retrieval activation likelihood estimation
DOI10.3389/fnagi.2016.00260
URL查看原文
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(31271108 ; National Science and Technology Pillar Program of China(2009BAI77B03) ; Knowledge Innovation Project of the Chinese Academy of Sciences(KSCX2-EW-J-8) ; CAS/SAFEA International Partnership Program for Creative Research Team(Y2CX131003) ; Institute of psychology, Chinese Academy of Sciences(1110000038 ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program(TSS-2015-06) ; CAS Key Laboratory of Mental Health, Institute of Psychology(KLMH2014ZK02 ; 30911120494 ; Y3CX151005) ; KLMH2014ZG10) ; 31070916 ; 31671157 ; 31400895)
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:000386956400001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MEDIAL TEMPORAL-LOBE ; DEFAULT MODE NETWORK ; DORSOLATERAL PREFRONTAL CORTEX ; RESONANCE-IMAGING CHANGES ; HEALTHY OLDER-ADULTS ; ALZHEIMERS-DISEASE ; PARIETAL CORTEX ; HIPPOCAMPAL ACTIVATION ; RECOGNITION MEMORY ; FUNCTIONAL CONNECTIVITY
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20708
专题中国科学院心理健康重点实验室
通讯作者Juan Li
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Lab Funct Connectome & Dev, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Pengyun,Li, Juan,Li, Hui-Jie,et al. Mild Cognitive Impairment Is Not "Mild" at All in Altered Activation of Episodic Memory Brain Networks: Evidence from ALE Meta-Analysis[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):1-16.
APA Wang, Pengyun,Li, Juan,Li, Hui-Jie,Huo, Lijuan,Li, Rui,&Juan Li.(2016).Mild Cognitive Impairment Is Not "Mild" at All in Altered Activation of Episodic Memory Brain Networks: Evidence from ALE Meta-Analysis.FRONTIERS IN AGING NEUROSCIENCE,8(0),1-16.
MLA Wang, Pengyun,et al."Mild Cognitive Impairment Is Not "Mild" at All in Altered Activation of Episodic Memory Brain Networks: Evidence from ALE Meta-Analysis".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):1-16.
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