Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems
Guo, JY; Wang, JY; Luo, F; Luo F
第一作者Guo JY
2010
发表期刊Journal of Psychopharmacology
通讯作者邮箱luof@psych.ac.cn
ISSN1561-1567
文章类型SCI
卷号24期号:10页码:1561-1567
Q分类Q1
产权排序1
摘要Amanzio and Benedetti (J Neurosci 1999; 19: 484-494) first addressed the conditions necessary for the activation of opioid and non-opioid placebo responses in human. Here, we investigated whether placebo analgesia is subdivided into opioid and non-opioid components in mice by using the model of hot-plate test. Drug conditioning was performed by the combination of the conditioned cue stimulus with the unconditioned drug stimulus, either opioid agonist morphine hydrochloride or non-opioid aspirin. Placebo analgesic responses were evoked by an exposure to a conditioned cue previously paired with drug conditioning. Morphine conditioning produced placebo responses that were completely antagonised by naloxone. By contrast, the conditioned cue after aspirin conditioning elicited a placebo effect that was not blocked by naloxone. Therefore, we first evoked opioid and non-opioid placebo responses in mice that were either naloxone-reversible or naloxone-insensitive, depending on the drug used in conditioning procedure. These findings support that the mechanisms underlying placebo analgesia may depend on the drug conditioning that was originally performed. The present procedure of mice may serve as a model for further understanding of the opioid and non-opioid mechanisms underlying placebo responses.
关键词Cue Endogenous Opioids Mice Morphine Nonsteroid Anti-inflammatory Drugs Placebo Analgesia
学科领域生理心理学/生物心理学
DOI10.1177/0269881109104848
收录类别SCI
语种英语
项目资助者NNSF(30570577, 30770688, 30800301, 30700223) ; the 100 Talented Plan of the Chinese Academy of Sciences ; 863 project of China(2006AA02Z431) ; IPSY(111000C131, 08CX043004, 07CX051005)
项目简介This study was supported by NNSF grants (30570577 and 30770688), the 100 Talented Plan of the Chinese Academy of Sciences, and the 863 project (2006AA02Z431) of China to LF; a Director starting grant (111000C131) from IPCAS, a projects for Young Scientist from IPCAS (08CX043004), and a NNSF grant (30800301) to GJY; a projects for Young Scientist from IPCAS (07CX051005) and a NNSF grant (30700223) to WJY.
WOS记录号WOS:000282822500017
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20721
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Luo F
作者单位Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
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Guo, JY,Wang, JY,Luo, F,et al. Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems[J]. Journal of Psychopharmacology,2010,24(10):1561-1567.
APA Guo, JY,Wang, JY,Luo, F,&Luo F.(2010).Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems.Journal of Psychopharmacology,24(10),1561-1567.
MLA Guo, JY,et al."Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems".Journal of Psychopharmacology 24.10(2010):1561-1567.
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