Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems

doi:10.1177/0269881109104848

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems
	Guo, JY; Wang, JY; Luo, F; Luo F
第一作者	Guo JY
通讯作者邮箱	luof@psych.ac.cn
心理所单位排序	1
摘要	Amanzio and Benedetti (J Neurosci 1999; 19: 484-494) first addressed the conditions necessary for the activation of opioid and non-opioid placebo responses in human. Here, we investigated whether placebo analgesia is subdivided into opioid and non-opioid components in mice by using the model of hot-plate test. Drug conditioning was performed by the combination of the conditioned cue stimulus with the unconditioned drug stimulus, either opioid agonist morphine hydrochloride or non-opioid aspirin. Placebo analgesic responses were evoked by an exposure to a conditioned cue previously paired with drug conditioning. Morphine conditioning produced placebo responses that were completely antagonised by naloxone. By contrast, the conditioned cue after aspirin conditioning elicited a placebo effect that was not blocked by naloxone. Therefore, we first evoked opioid and non-opioid placebo responses in mice that were either naloxone-reversible or naloxone-insensitive, depending on the drug used in conditioning procedure. These findings support that the mechanisms underlying placebo analgesia may depend on the drug conditioning that was originally performed. The present procedure of mice may serve as a model for further understanding of the opioid and non-opioid mechanisms underlying placebo responses.
关键词	Cue Endogenous Opioids Mice Morphine Nonsteroid Anti-inflammatory Drugs Placebo Analgesia
学科领域	生理心理学/生物心理学
	2010
语种	英语
DOI	10.1177/0269881109104848
发表期刊	Journal of Psychopharmacology
ISSN	1561-1567
卷号	24 期号:10 页码:1561-1567
期刊论文类型	SCI
收录类别	SCI
项目简介	This study was supported by NNSF grants (30570577 and 30770688), the 100 Talented Plan of the Chinese Academy of Sciences, and the 863 project (2006AA02Z431) of China to LF; a Director starting grant (111000C131) from IPCAS, a projects for Young Scientist from IPCAS (08CX043004), and a NNSF grant (30800301) to GJY; a projects for Young Scientist from IPCAS (07CX051005) and a NNSF grant (30700223) to WJY.
WOS记录号	WOS:000282822500017
Q分类	Q1
资助机构	NNSF(30570577, 30770688, 30800301, 30700223) ; the 100 Talented Plan of the Chinese Academy of Sciences ; 863 project of China(2006AA02Z431) ; IPSY(111000C131, 08CX043004, 07CX051005)
引用统计	被引频次：61[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20721
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Luo F
作者单位	Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
第一作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Guo, JY,Wang, JY,Luo, F,et al. Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems[J]. Journal of Psychopharmacology,2010,24(10):1561-1567.
APA	Guo, JY,Wang, JY,Luo, F,&Luo F.(2010).Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems.Journal of Psychopharmacology,24(10),1561-1567.
MLA	Guo, JY,et al."Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems".Journal of Psychopharmacology 24.10(2010):1561-1567.

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