PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems
Guo, JY; Wang, JY; Luo, F; Luo F
First AuthorGuo JY
2010
Source PublicationJournal of Psychopharmacology
Correspondent Emailluof@psych.ac.cn
ISSN1561-1567
SubtypeSCI
Volume24Issue:10Pages:1561-1567
QuartileQ1
Contribution Rank1
AbstractAmanzio and Benedetti (J Neurosci 1999; 19: 484-494) first addressed the conditions necessary for the activation of opioid and non-opioid placebo responses in human. Here, we investigated whether placebo analgesia is subdivided into opioid and non-opioid components in mice by using the model of hot-plate test. Drug conditioning was performed by the combination of the conditioned cue stimulus with the unconditioned drug stimulus, either opioid agonist morphine hydrochloride or non-opioid aspirin. Placebo analgesic responses were evoked by an exposure to a conditioned cue previously paired with drug conditioning. Morphine conditioning produced placebo responses that were completely antagonised by naloxone. By contrast, the conditioned cue after aspirin conditioning elicited a placebo effect that was not blocked by naloxone. Therefore, we first evoked opioid and non-opioid placebo responses in mice that were either naloxone-reversible or naloxone-insensitive, depending on the drug used in conditioning procedure. These findings support that the mechanisms underlying placebo analgesia may depend on the drug conditioning that was originally performed. The present procedure of mice may serve as a model for further understanding of the opioid and non-opioid mechanisms underlying placebo responses.
KeywordCue Endogenous Opioids Mice Morphine Nonsteroid Anti-inflammatory Drugs Placebo Analgesia
Subject Area生理心理学/生物心理学
DOI10.1177/0269881109104848
Indexed BySCI
Language英语
Funding OrganizationNNSF(30570577, 30770688, 30800301, 30700223) ; the 100 Talented Plan of the Chinese Academy of Sciences ; 863 project of China(2006AA02Z431) ; IPSY(111000C131, 08CX043004, 07CX051005)
Project Intro.This study was supported by NNSF grants (30570577 and 30770688), the 100 Talented Plan of the Chinese Academy of Sciences, and the 863 project (2006AA02Z431) of China to LF; a Director starting grant (111000C131) from IPCAS, a projects for Young Scientist from IPCAS (08CX043004), and a NNSF grant (30800301) to GJY; a projects for Young Scientist from IPCAS (07CX051005) and a NNSF grant (30700223) to WJY.
WOS IDWOS:000282822500017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20721
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorLuo F
AffiliationKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Guo, JY,Wang, JY,Luo, F,et al. Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems[J]. Journal of Psychopharmacology,2010,24(10):1561-1567.
APA Guo, JY,Wang, JY,Luo, F,&Luo F.(2010).Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems.Journal of Psychopharmacology,24(10),1561-1567.
MLA Guo, JY,et al."Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems".Journal of Psychopharmacology 24.10(2010):1561-1567.
Files in This Item:
File Name/Size DocType Version Access License
Dissection of placeb(266KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo, JY]'s Articles
[Wang, JY]'s Articles
[Luo, F]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo, JY]'s Articles
[Wang, JY]'s Articles
[Luo, F]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo, JY]'s Articles
[Wang, JY]'s Articles
[Luo, F]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Dissection of placebo analgesia in mice the conditions for activation of opioid and non-opioid systems.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.