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Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied
Qi, Wei-Jing; Wang, Wei; Wang, Ning; Wang, Jin-Yan; Luo, Fei; Wang JY; Luo F
First AuthorQi WJ
2013
Source PublicationPsych Journal
Correspondent Emailwangjy@psych.ac.cn ; luof@psych.ac.cn
ISSN2046-0260
Volume2Issue:2Pages:133-145
Contribution Rank1
AbstractNumerous studies have shown that pain perception is strongly influenced by depression. However, very few studies have examined whether pain perception is altered in the remission period of depression, and what role the fronto-limbic circuits may play in the behavioral changes associated with remission. Using an unpredictable chronic mild stress (UCMS) animal model of depression, the present study investigated pain-related behaviors in rats with prior exposure to a UCMS stimulus. The gamma-aminobutyric acid (GABA)A receptor agonist muscimol was microinjected bilaterally into the basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) to examine the modulation of pain by these brain regions in the recovery state. Rats with a depression-like history displayed increased ongoing pain behavior in the formalin test, although their thermal pain thresholds were unchanged. Intra-BLA muscimol during the recovery phase dramatically decreased formalin-induced pain behavior and also significantly increased rats' sucrose preference. By contrast, in the mPFC, muscimol produced the opposite effect, suggesting different, perhaps opposing, roles of the BLA and mPFC in mediating the influence of prior UCMS exposure on pain perception. Taken together, these results demonstrated that a depressive experience may cause long-term alterations in limbic circuit excitability and thus lead to long-lasting changes in pain perception.
KeywordAmygdala Depression Medial Prefrontal Cortex Pain
Subject Area生理心理学/生物心理学
DOI10.1002/pchj.27
Indexed By其他
Language英语
Funding OrganizationFIC NIH HHS(R03 TW008038
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20724
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang JY; Luo F
AffiliationKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Qi, Wei-Jing,Wang, Wei,Wang, Ning,et al. Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied[J]. Psych Journal,2013,2(2):133-145.
APA Qi, Wei-Jing.,Wang, Wei.,Wang, Ning.,Wang, Jin-Yan.,Luo, Fei.,...&Luo F.(2013).Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied.Psych Journal,2(2),133-145.
MLA Qi, Wei-Jing,et al."Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied".Psych Journal 2.2(2013):133-145.
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