Institutional Repository of Key Laboratory of Mental Health, CAS
Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied | |
Qi, Wei-Jing; Wang, Wei; Wang, Ning; Wang, Jin-Yan; Luo, Fei | |
第一作者 | Qi WJ |
通讯作者邮箱 | wangjy@psych.ac.cn ; luof@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Numerous studies have shown that pain perception is strongly influenced by depression. However, very few studies have examined whether pain perception is altered in the remission period of depression, and what role the fronto-limbic circuits may play in the behavioral changes associated with remission. Using an unpredictable chronic mild stress (UCMS) animal model of depression, the present study investigated pain-related behaviors in rats with prior exposure to a UCMS stimulus. The gamma-aminobutyric acid (GABA)A receptor agonist muscimol was microinjected bilaterally into the basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) to examine the modulation of pain by these brain regions in the recovery state. Rats with a depression-like history displayed increased ongoing pain behavior in the formalin test, although their thermal pain thresholds were unchanged. Intra-BLA muscimol during the recovery phase dramatically decreased formalin-induced pain behavior and also significantly increased rats' sucrose preference. By contrast, in the mPFC, muscimol produced the opposite effect, suggesting different, perhaps opposing, roles of the BLA and mPFC in mediating the influence of prior UCMS exposure on pain perception. Taken together, these results demonstrated that a depressive experience may cause long-term alterations in limbic circuit excitability and thus lead to long-lasting changes in pain perception. |
关键词 | Amygdala Depression Medial Prefrontal Cortex Pain |
学科领域 | 生理心理学/生物心理学 |
2013 | |
语种 | 英语 |
DOI | 10.1002/pchj.27 |
发表期刊 | Psych Journal |
ISSN | 2046-0260 |
卷号 | 2期号:2页码:133-145 |
期刊论文类型 | 实证研究 |
收录类别 | SSCI |
WOS分区 | Q4 |
资助机构 | FIC NIH HHS(R03 TW008038 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/20724 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Jin-Yan; Luo, Fei |
作者单位 | Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. |
第一作者单位 | 中国科学院心理研究所 |
通讯作者单位 | 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Qi, Wei-Jing,Wang, Wei,Wang, Ning,et al. Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied[J]. Psych Journal,2013,2(2):133-145. |
APA | Qi, Wei-Jing,Wang, Wei,Wang, Ning,Wang, Jin-Yan,&Luo, Fei.(2013).Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied.Psych Journal,2(2),133-145. |
MLA | Qi, Wei-Jing,et al."Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied".Psych Journal 2.2(2013):133-145. |
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