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Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied
Qi, Wei-Jing; Wang, Wei; Wang, Ning; Wang, Jin-Yan; Luo, Fei; Wang JY; Luo F
第一作者Qi WJ
2013
发表期刊Psych Journal
通讯作者邮箱wangjy@psych.ac.cn ; luof@psych.ac.cn
ISSN2046-0260
卷号2期号:2页码:133-145
产权排序1
摘要Numerous studies have shown that pain perception is strongly influenced by depression. However, very few studies have examined whether pain perception is altered in the remission period of depression, and what role the fronto-limbic circuits may play in the behavioral changes associated with remission. Using an unpredictable chronic mild stress (UCMS) animal model of depression, the present study investigated pain-related behaviors in rats with prior exposure to a UCMS stimulus. The gamma-aminobutyric acid (GABA)A receptor agonist muscimol was microinjected bilaterally into the basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) to examine the modulation of pain by these brain regions in the recovery state. Rats with a depression-like history displayed increased ongoing pain behavior in the formalin test, although their thermal pain thresholds were unchanged. Intra-BLA muscimol during the recovery phase dramatically decreased formalin-induced pain behavior and also significantly increased rats' sucrose preference. By contrast, in the mPFC, muscimol produced the opposite effect, suggesting different, perhaps opposing, roles of the BLA and mPFC in mediating the influence of prior UCMS exposure on pain perception. Taken together, these results demonstrated that a depressive experience may cause long-term alterations in limbic circuit excitability and thus lead to long-lasting changes in pain perception.
关键词Amygdala Depression Medial Prefrontal Cortex Pain
学科领域生理心理学/生物心理学
DOI10.1002/pchj.27
收录类别其他
语种英语
项目资助者FIC NIH HHS(R03 TW008038
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20724
专题中国科学院心理健康重点实验室
通讯作者Wang JY; Luo F
作者单位Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
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GB/T 7714
Qi, Wei-Jing,Wang, Wei,Wang, Ning,et al. Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied[J]. Psych Journal,2013,2(2):133-145.
APA Qi, Wei-Jing.,Wang, Wei.,Wang, Ning.,Wang, Jin-Yan.,Luo, Fei.,...&Luo F.(2013).Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied.Psych Journal,2(2),133-145.
MLA Qi, Wei-Jing,et al."Depressive-like history alters persistent pain behavior in rats: Opposite contribution of frontal cortex and amygdala implied".Psych Journal 2.2(2013):133-145.
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