中国科学院心理研究所机构知识库

目的　利用全脑功能磁共振成像 (fMRI)技术 ,探讨参与利手和非利手简单随意运动的关键脑结构。方法　采用Siemens公司Sonata 1.5T磁共振成像系统 ,对 7名健康右利手志愿者的利手或非利手食指按键运动进行了全脑扫描。数据经头动矫正、空间标准化、空间平滑等预处理后 ,通过互相关分析分别获得利手和非利手运动的脑激活统计参数图。结果　利手运动主要激活对侧初级运动区 (MI)、双侧辅助运动区 (SMA)、双侧运动二区 (MII)和同侧小脑 ,而非利手运动除以上区域外还激活了对侧前运动区 (PMC) ,而且SMA和MII的激活体积大于利手运动。结论　全脑fMRI研究表明 ,随意运动依赖于大脑皮质和小脑等许多脑结构的参与。与利手运动相比 ,非利手运动更依赖于SMA和PMC等高级运动控制区。

To identify the neural substrates of voluntary movements of dominant and subdominant hands by using the whole-brain functional magnetic resonance imaging. Methods Seven right-handed healthy volunteers were scanned at a Sonata 1. 5 Tesla magnetic resonance imaging scanner ( Siemens)while they were performing the visually instructive movement tasks with their right and left index fingers. Image datawere co-registered to correct head motion, spatially normalized according to the standard coordinates, andspatially smoothed with isotopic Guassian Kernel. Statistical parametric maps ( activation maps) for right and lefthands were generated respectively by cross-correlation analysis. ResultsVoluntarymovements of the right/ dominanthand mainly activated contralateral primary motor cortex (MI ) , bilateral supplementary motor area ( SMA) ,bilateral second motor area ( MII ) , and ipsilateral cerebellum, whereas movements of the left/ subdominant handadditionally elicited activation in contralateral premotor area ( PMC) . Moreover, activation volumes in SMA and MII duringmovements of the subdominant hand were significantly larger than those during movements of the dominant hand. Conclusion: A large set of structures in the cerebral cortex and cerebellum is involved in voluntary movements, as revealed by whole brain-based fMRI. Movements of the subdominant hand are moredependent on higher control areas, such as SMA and PMC, comparing to movements of the dominant hand.