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The different effects of maternal separation on spatial learning and reversal learning in rats
Wang, Qiong; Li, Man; Du, Wei; Shao, Feng; Wang, Weiwen; Shao, F
2015
发表期刊Behavioural Brain Research
ISSN0166-4328
文章类型Article
卷号280期号:280页码:16-23
Q分类Q2
产权排序2
摘要Early postnatal maternal separation (MS) can play an important role in the development of psychopathologies during ontogeny. In the present study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1 to 21) on locomotor activity and anxiety behavior in open field, spatial learning and reversal learning in Morris water maze of male and female juvenile (PND 21), adolescent (PND 35) and early adult (PND 56) Wistar rats. The results indicated that MS increased locomotor activity of rats across all ages and reduced anxiety behavior of adolescent rats in open field test. MS also increased swim distance in spatial learning and decreased escape latency in reversal learning in adolescent and early adult rats. Additionally, for socially reared rats, there was increased spontaneous locomotion with age, decreased reversal learning ability with age. The present study provides novel insights into the consequences of MS and demonstrates unique age-dependent changes at the behavioral levels. (C) 2014 Elsevier B.V. All rights reserved.
关键词Maternal Separation Locomotor Activity Anxiety Spatial Learning Reversal Learning
学科领域生理心理学/生物心理学
DOI10.1016/j.bbr.2014.11.040
收录类别SCI
语种英语
项目简介This work was supported by the National Natural Science Foundation of China (Grant No. 31470988), the National Natural Science Foundation of China (Grant No. 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号WOS:000348255400003
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20741
专题中国科学院心理健康重点实验室
通讯作者Shao, F
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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GB/T 7714
Wang, Qiong,Li, Man,Du, Wei,et al. The different effects of maternal separation on spatial learning and reversal learning in rats[J]. Behavioural Brain Research,2015,280(280):16-23.
APA Wang, Qiong,Li, Man,Du, Wei,Shao, Feng,Wang, Weiwen,&Shao, F.(2015).The different effects of maternal separation on spatial learning and reversal learning in rats.Behavioural Brain Research,280(280),16-23.
MLA Wang, Qiong,et al."The different effects of maternal separation on spatial learning and reversal learning in rats".Behavioural Brain Research 280.280(2015):16-23.
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