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The different effects of maternal separation on spatial learning and reversal learning in rats
Wang, Qiong; Li, Man; Du, Wei; Shao, Feng; Wang, Weiwen; Shao, F
2015
Source PublicationBehavioural Brain Research
ISSN0166-4328
SubtypeArticle
Volume280Issue:280Pages:16-23
QuartileQ2
Contribution Rank2
AbstractEarly postnatal maternal separation (MS) can play an important role in the development of psychopathologies during ontogeny. In the present study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1 to 21) on locomotor activity and anxiety behavior in open field, spatial learning and reversal learning in Morris water maze of male and female juvenile (PND 21), adolescent (PND 35) and early adult (PND 56) Wistar rats. The results indicated that MS increased locomotor activity of rats across all ages and reduced anxiety behavior of adolescent rats in open field test. MS also increased swim distance in spatial learning and decreased escape latency in reversal learning in adolescent and early adult rats. Additionally, for socially reared rats, there was increased spontaneous locomotion with age, decreased reversal learning ability with age. The present study provides novel insights into the consequences of MS and demonstrates unique age-dependent changes at the behavioral levels. (C) 2014 Elsevier B.V. All rights reserved.
KeywordMaternal Separation Locomotor Activity Anxiety Spatial Learning Reversal Learning
Subject Area生理心理学/生物心理学
DOI10.1016/j.bbr.2014.11.040
Indexed BySCI
Language英语
Project Intro.This work was supported by the National Natural Science Foundation of China (Grant No. 31470988), the National Natural Science Foundation of China (Grant No. 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS IDWOS:000348255400003
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Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20741
Collection中国科学院心理健康重点实验室
Corresponding AuthorShao, F
Affiliation1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qiong,Li, Man,Du, Wei,et al. The different effects of maternal separation on spatial learning and reversal learning in rats[J]. Behavioural Brain Research,2015,280(280):16-23.
APA Wang, Qiong,Li, Man,Du, Wei,Shao, Feng,Wang, Weiwen,&Shao, F.(2015).The different effects of maternal separation on spatial learning and reversal learning in rats.Behavioural Brain Research,280(280),16-23.
MLA Wang, Qiong,et al."The different effects of maternal separation on spatial learning and reversal learning in rats".Behavioural Brain Research 280.280(2015):16-23.
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