The different effects of maternal separation on spatial learning and reversal learning in rats

doi:10.1016/j.bbr.2014.11.040

	The different effects of maternal separation on spatial learning and reversal learning in rats
	Wang, Qiong; Li, Man ; Du, Wei ; Shao, Feng ; Wang, Weiwen; Shao, F
心理所单位排序	2
摘要	Early postnatal maternal separation (MS) can play an important role in the development of psychopathologies during ontogeny. In the present study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1 to 21) on locomotor activity and anxiety behavior in open field, spatial learning and reversal learning in Morris water maze of male and female juvenile (PND 21), adolescent (PND 35) and early adult (PND 56) Wistar rats. The results indicated that MS increased locomotor activity of rats across all ages and reduced anxiety behavior of adolescent rats in open field test. MS also increased swim distance in spatial learning and decreased escape latency in reversal learning in adolescent and early adult rats. Additionally, for socially reared rats, there was increased spontaneous locomotion with age, decreased reversal learning ability with age. The present study provides novel insights into the consequences of MS and demonstrates unique age-dependent changes at the behavioral levels. (C) 2014 Elsevier B.V. All rights reserved.
关键词	Maternal Separation Locomotor Activity Anxiety Spatial Learning Reversal Learning
学科领域	生理心理学/生物心理学
	2015
语种	英语
DOI	10.1016/j.bbr.2014.11.040
发表期刊	Behavioural Brain Research
ISSN	0166-4328
卷号	280 期号:280 页码:16-23
期刊论文类型	Article
收录类别	SCI
项目简介	This work was supported by the National Natural Science Foundation of China (Grant No. 31470988), the National Natural Science Foundation of China (Grant No. 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号	WOS:000348255400003
Q分类	Q2
引用统计	被引频次：46[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20741
专题	中国科学院心理健康重点实验室
通讯作者	Shao, F
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qiong,Li, Man,Du, Wei,et al. The different effects of maternal separation on spatial learning and reversal learning in rats[J]. Behavioural Brain Research,2015,280(280):16-23.
APA	Wang, Qiong,Li, Man,Du, Wei,Shao, Feng,Wang, Weiwen,&Shao, F.(2015).The different effects of maternal separation on spatial learning and reversal learning in rats.Behavioural Brain Research,280(280),16-23.
MLA	Wang, Qiong,et al."The different effects of maternal separation on spatial learning and reversal learning in rats".Behavioural Brain Research 280.280(2015):16-23.

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