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A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans | |
Murta, T.1,2,3; Hu, L.4![]() | |
摘要 | In current fMRI studies designed to map BOLD changes related to interictal epileptiform discharges (IED), which are recorded on simultaneous EEG, the information contained in the morphology and field extent of the EEG events is exclusively used for their classification. Usually, a BOLD predictor based on IED onset times alone is constructed, effectively treating all events as identical. We used intracranial EEG (icEEG)-fMRI data simultaneously recorded in humans to investigate the effect of including any of the features: amplitude, width (duration), slope of the rising phase, energy (area under the curve), or spatial field extent (number of contacts over which the sharp wave was observed) of the fast wave of the IED (the sharp wave), into the BOLD model, to better understand the neurophysiological origin of sharp wave-related BOLD changes, in the immediate vicinity of the recording contacts. Among the features considered, the width was the only one found to explain a significant amount of additional variance, suggesting that the amplitude of the BOLD signal depends more on the duration of the underlying field potential (reflected in the sharp wave width) than on the degree of neuronal activity synchrony (reflected in the sharp wave amplitude), and, consequently, that including inter-event variations of the sharp wave width in the BOLD signal model may increase the sensitivity of forthcoming EEG-fMRI studies of epileptic activity. (C) 2016 The Authors. Published by Elsevier Inc. |
关键词 | Intracranial Eeg Bold Fmri Electro-haemodynamic Coupling Sharp Wave |
2016-11-15 | |
语种 | 英语 |
DOI | 10.1016/j.neuroimage.2016.08.001 |
发表期刊 | NEUROIMAGE
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ISSN | 1053-8119 |
卷号 | 142期号:0页码:361-370 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | INTERICTAL EPILEPTIFORM DISCHARGES ; LOCAL-FIELD POTENTIALS ; EVENT-RELATED FMRI ; BOLD SIGNAL ; NEURONAL-ACTIVITY ; FUNCTIONAL MRI ; FOCAL EPILEPSY ; FIRING PATTERNS ; NEGATIVE BOLD ; SHARP WAVES |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000387986000029 |
Q分类 | Q1 |
资助机构 | FCT, Portugal(SFRH/BD/80421/2011) ; Medical Research Council, United Kingdom(G0301067) ; National Institute for Health Research UCL Hospitals Biomedical Research Centre, United Kingdom |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/20773 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.UCL Inst Neurol, Dept Clin & Expt Epilepsy, 33 Queen Sq BOX 29, London WC1N 3BG, England 2.Univ Lisbon, Inst Super Tecn, Inst Syst & Robot, Lisbon, Portugal 3.Univ Lisbon, Inst Super Tecn, Dept Bioengn, Lisbon, Portugal 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 5.UCL Inst Child Heath, London, England |
推荐引用方式 GB/T 7714 | Murta, T.,Hu, L.,Tierney, T. M.,et al. A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans[J]. NEUROIMAGE,2016,142(0):361-370. |
APA | Murta, T..,Hu, L..,Tierney, T. M..,Chaudhary, U. J..,Walker, M. C..,...&Lemieux, L..(2016).A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans.NEUROIMAGE,142(0),361-370. |
MLA | Murta, T.,et al."A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans".NEUROIMAGE 142.0(2016):361-370. |
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A study of the elect(868KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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