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A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans
Murta, T.1,2,3; Hu, L.4; Tierney, T. M.5; Chaudhary, U. J.1; Walker, M. C.1; Carmichael, D. W.5; Figueiredo, P.2,3; Lemieux, L.1
2016-11-15
Source PublicationNEUROIMAGE
ISSN1053-8119
SubtypeArticle
Volume142Issue:0Pages:361-370
Abstract

In current fMRI studies designed to map BOLD changes related to interictal epileptiform discharges (IED), which are recorded on simultaneous EEG, the information contained in the morphology and field extent of the EEG events is exclusively used for their classification. Usually, a BOLD predictor based on IED onset times alone is constructed, effectively treating all events as identical. We used intracranial EEG (icEEG)-fMRI data simultaneously recorded in humans to investigate the effect of including any of the features: amplitude, width (duration), slope of the rising phase, energy (area under the curve), or spatial field extent (number of contacts over which the sharp wave was observed) of the fast wave of the IED (the sharp wave), into the BOLD model, to better understand the neurophysiological origin of sharp wave-related BOLD changes, in the immediate vicinity of the recording contacts. Among the features considered, the width was the only one found to explain a significant amount of additional variance, suggesting that the amplitude of the BOLD signal depends more on the duration of the underlying field potential (reflected in the sharp wave width) than on the degree of neuronal activity synchrony (reflected in the sharp wave amplitude), and, consequently, that including inter-event variations of the sharp wave width in the BOLD signal model may increase the sensitivity of forthcoming EEG-fMRI studies of epileptic activity. (C) 2016 The Authors. Published by Elsevier Inc.

KeywordIntracranial Eeg Bold Fmri Electro-haemodynamic Coupling Sharp Wave
DOI10.1016/j.neuroimage.2016.08.001
Indexed BySCI
Language英语
Funding OrganizationFCT, Portugal(SFRH/BD/80421/2011) ; Medical Research Council, United Kingdom(G0301067) ; National Institute for Health Research UCL Hospitals Biomedical Research Centre, United Kingdom
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000387986000029
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordINTERICTAL EPILEPTIFORM DISCHARGES ; LOCAL-FIELD POTENTIALS ; EVENT-RELATED FMRI ; BOLD SIGNAL ; NEURONAL-ACTIVITY ; FUNCTIONAL MRI ; FOCAL EPILEPSY ; FIRING PATTERNS ; NEGATIVE BOLD ; SHARP WAVES
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20773
Collection中国科学院心理健康重点实验室
Affiliation1.UCL Inst Neurol, Dept Clin & Expt Epilepsy, 33 Queen Sq BOX 29, London WC1N 3BG, England
2.Univ Lisbon, Inst Super Tecn, Inst Syst & Robot, Lisbon, Portugal
3.Univ Lisbon, Inst Super Tecn, Dept Bioengn, Lisbon, Portugal
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
5.UCL Inst Child Heath, London, England
Recommended Citation
GB/T 7714
Murta, T.,Hu, L.,Tierney, T. M.,et al. A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans[J]. NEUROIMAGE,2016,142(0):361-370.
APA Murta, T..,Hu, L..,Tierney, T. M..,Chaudhary, U. J..,Walker, M. C..,...&Lemieux, L..(2016).A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans.NEUROIMAGE,142(0),361-370.
MLA Murta, T.,et al."A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans".NEUROIMAGE 142.0(2016):361-370.
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