屈光参差性弱视患者的视觉系统中存在更强的侧抑制
其他题名Stronger Lateral Inhibition in the Dysfunctional Visual System of Anisometropic Amblyopia
Jinfeng Huang; Yifeng Zhou; Caiyuan Liu; Zhongjian Liu; Tzvetomir Tzvetanov
2016
会议名称2016年第一届北京视觉科学会议
会议日期2016-07
会议地点北京
会议主办者中国科学院心理研究所
其他摘要PURPOSE: Anisometropic amblyopia, one type of lazy eye, is a neuronal vision disorder accompanied with weak or strong spatial vision loss in the amblyopic eye (AE) when compared to normal eyes. While the plausible neural substrates and consequences on visual perception have been studied, its relation to changes of monocular early neuronal processing remains unclear.
METHODS: Here we used the monocular tilt illusion as a probe of primary visual cortex inhibitory interactions and we modeled amblyopic low-level perception disturbances through network modi?cations at monocular V1 stages.
RESULTS: We found that the amount of orientation misperception was higher in AEs when compared with non-amblyopic (NAEs) and neurotypical eyes (NTEs). Importantly, it was highly correlated to subject's AE peak contrast sensitivity. Near the peak of contrast sensitivity, the model predicted from the tilt data a broader orientation tuning width of AEs than NAEs and NTEs without any relation to subjects' contrast sensitivity functions (CSF).Additionally, for subjects with stronger loss of peak CSF, these correlations could be explained by stronger lateral inhibition in AEs.
CONCLUSIONS: Through psychophysics experiments in humans and computational modeling of V1, our study provides new fundamental insights into visual neuronal disorders through inhibitory prevalence.
关键词Anisometropic amblyopia lateral inhibition tilt illusion monocular early neuronal processing
学科领域感知觉心理学
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收录类别其他
语种英语
文献类型会议论文
条目标识符http://ir.psych.ac.cn/handle/311026/20782
专题心理所主办学术会议_2016年第一届北京视觉科学会议_会议摘要
作者单位1.Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
2.Research and Treatment Center of Amblyopia and Strabismus, University of Science and Technology of China, 230027 Hefei, China
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Jinfeng Huang,Yifeng Zhou,Caiyuan Liu,等. 屈光参差性弱视患者的视觉系统中存在更强的侧抑制[C]. 见:2016年第一届北京视觉科学会议. 北京. 2016-07.http://vision.csp.escience.cn/dct/page/1.
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