Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability

doi:10.1093/cercor/bhw241

	Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability
	Xu, Ting1,2,3,4 ; Opitz, Alexander 3,4; Craddock, R. Cameron 3,4; Wright, Margaret J.5,6; Zuo, Xi-Nian1,2 ; Milham, Michael P.3,4
摘要	Resting state fMRI (R-fMRI) is a powerful in-vivo tool for examining the functional architecture of the human brain. Recent studies have demonstrated the ability to characterize transitions between functionally distinct cortical areas through the mapping of gradients in intrinsic functional connectivity (iFC) profiles. To date, this novel approach has primarily been applied to iFC profiles averaged across groups of individuals, or in one case, a single individual scanned multiple times. Here, we used a publically available R-fMRI dataset, in which 30 healthy participants were scanned 10 times (10 min per session), to investigate differences in full-brain transition profiles (i.e., gradient maps, edge maps) across individuals, and their reliability. 10-min R-fMRI scans were sufficient to achieve high accuracies in efforts to "fingerprint" individuals based upon full-brain transition profiles. Regarding test-retest reliability, the image-wise intraclass correlation coefficient (ICC) was moderate, and vertex-level ICC varied depending on region; larger durations of data yielded higher reliability scores universally. Initial application of gradient-based methodologies to a recently published dataset obtained from twins suggested inter-individual variation in areal profiles might have genetic and familial origins. Overall, these results illustrate the utility of gradient-based iFC approaches for studying inter-individual variation in brain function.
关键词	areal organization individual differences reliability resting-state fMRI transition zones
	2016-11-01
语种	英语
DOI	10.1093/cercor/bhw241
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
卷号	26 期号:11 页码:4192-4211
期刊论文类型	Article
收录类别	SCI
WOS关键词	FUNCTIONAL CONNECTIVITY ARCHITECTURE ; HUMAN CEREBRAL-CORTEX ; SURFACE-BASED ANALYSIS ; CORTICAL SURFACE ; INDIVIDUAL VARIABILITY ; COORDINATE SYSTEM ; DISCOVERY SCIENCE ; GENETIC-CONTROL ; FMRI DATA ; NETWORKS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000388532300007
资助机构	National Basic Research (973) Program(2015CB351702) ; Funds of International Exchange for Post-doctoral Scientists of China ; National Institiute of Health(NIMH U01MH099059 ; Natural Science Foundation of China(81270023 ; National Science Foundation for Post-doctoral Scientists of China(2013M530073) ; Chinese Academy of Sciences(KSZD-EW-TZ-002) ; NIMH BRAINS R01-MH101555) ; 81278412 ; 81171409 ; 81000583 ; 81471740 ; 81220108014)
引用统计	被引频次：58[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20830
专题	中国科学院行为科学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing 100101, Peoples R China 3.Child Mind Inst, Ctr Developing Brain, 445 Pk Ave, New York, NY 10022 USA 4.Nathan S Kline Inst Psychiat Res, Ctr Biomed Imaging & Neuromodulat, Orangeburg, NY 10962 USA 5.Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia 6.Univ Queensland, Ctr Adv Imaging, St Lucia, Qld 4072, Australia
第一作者单位	中国科学院行为科学重点实验室
推荐引用方式 GB/T 7714	Xu, Ting,Opitz, Alexander,Craddock, R. Cameron,et al. Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability[J]. CEREBRAL CORTEX,2016,26(11):4192-4211.
APA	Xu, Ting,Opitz, Alexander,Craddock, R. Cameron,Wright, Margaret J.,Zuo, Xi-Nian,&Milham, Michael P..(2016).Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability.CEREBRAL CORTEX,26(11),4192-4211.
MLA	Xu, Ting,et al."Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability".CEREBRAL CORTEX 26.11(2016):4192-4211.

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