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Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study
Gao, Cuihua1; Liu Wenhua2; Liu, Yanli1; Ruan, Xiuhang1; Chen, Xin1; Liu, Lingling1; Yu, Shaode3; Chan, Raymond C. K.4; Wei, Xinhua1; Jiang, Xinqing1
2016-12-05
Source PublicationFRONTIERS IN HUMAN NEUROSCIENCE
ISSN1662-5161
SubtypeArticle
Volume10Issue:0Pages:1-9
Abstract

Abnormal functional connectivity (FC) at rest has been identified in clinical depressive disorder. However, very few studies have been conducted to understand the underlying neural substrates of subclinical depression. The newly proposed centrality analysis approach has been increasingly used to explore the large-scale brain network of mental diseases. This study aimed to identify the degree centrality (DC) alteration of the brain network in subclinical depressive subjects. Thirty-seven candidates with subclinical depression and 34 well matched healthy controls (HCs) were recruited from the same sample of college students. All subjects underwent a resting-state fMRI (rs-fMRI) scan to assess the DC of the whole brain. Compared with controls, subclinical depressive subjects displayed decreased DC in the right parahippocampal gyrus (PHG), left PHG/amygdala, and left caudate and elevated DC in the right posterior parietal lobule (PPL), left inferior frontal gyrus (IFG) and left middle frontal gyrus (MFG). In addition, by using receiver operating characteristic (ROC) analysis, we determined that the DC values in the regions with altered FC between the two groups can be used to differentiate subclinical depressive subjects from HCs. We suggest that decreased DC in subcortical and increased DC in cortical regions might be the neural substrates of subclinical depression.

Keywordsubclinical depression young adults magnetic resonance imaging resting-state functional connectivity degree centrality
DOI10.3389/fnhum.2016.00617
Indexed BySCI
Language英语
Funding OrganizationScience and Technology Planning Project of Guangdong Province(20138021800063) ; Science and Technology Planning Project of Guangzhou(2014J14100071) ; Strategic Priority Research Program (B) of the Chinese Academy of Sciences(XDB02030002) ; Beijing Training Project for Leading Talents in ST(Z151100000315020)
WOS Research AreaNeurosciences & Neurology ; Psychology
WOS SubjectNeurosciences ; Psychology
WOS IDWOS:000389378300001
WOS HeadingsScience & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS KeywordFUNCTIONAL CONNECTIVITY DENSITY ; ABNORMAL DEGREE CENTRALITY ; MODE NETWORK CONNECTIVITY ; MAJOR DEPRESSION ; DEFAULT-MODE ; SUBTHRESHOLD DEPRESSION ; UNIPOLAR DEPRESSION ; BIPOLAR DISORDER ; BRAIN NETWORKS ; AMYGDALA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20929
Collection中国科学院心理健康重点实验室
Affiliation1.Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Guangzhou, Guangdong, Peoples R China
2.Guangzhou Med Univ, Fac Hlth Management, Guangzhou, Guangdong, Peoples R China
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Gao, Cuihua,Liu Wenhua,Liu, Yanli,et al. Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2016,10(0):1-9.
APA Gao, Cuihua.,Liu Wenhua.,Liu, Yanli.,Ruan, Xiuhang.,Chen, Xin.,...&Jiang, Xinqing.(2016).Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study.FRONTIERS IN HUMAN NEUROSCIENCE,10(0),1-9.
MLA Gao, Cuihua,et al."Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study".FRONTIERS IN HUMAN NEUROSCIENCE 10.0(2016):1-9.
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