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Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study
Gao, Cuihua1; Liu Wenhua2; Liu, Yanli1; Ruan, Xiuhang1; Chen, Xin1; Liu, Lingling1; Yu, Shaode3; Chan, Raymond C. K.4; Wei, Xinhua1; Jiang, Xinqing1
2016-12-05
发表期刊FRONTIERS IN HUMAN NEUROSCIENCE
ISSN1662-5161
文章类型Article
卷号10期号:0页码:1-9
摘要

Abnormal functional connectivity (FC) at rest has been identified in clinical depressive disorder. However, very few studies have been conducted to understand the underlying neural substrates of subclinical depression. The newly proposed centrality analysis approach has been increasingly used to explore the large-scale brain network of mental diseases. This study aimed to identify the degree centrality (DC) alteration of the brain network in subclinical depressive subjects. Thirty-seven candidates with subclinical depression and 34 well matched healthy controls (HCs) were recruited from the same sample of college students. All subjects underwent a resting-state fMRI (rs-fMRI) scan to assess the DC of the whole brain. Compared with controls, subclinical depressive subjects displayed decreased DC in the right parahippocampal gyrus (PHG), left PHG/amygdala, and left caudate and elevated DC in the right posterior parietal lobule (PPL), left inferior frontal gyrus (IFG) and left middle frontal gyrus (MFG). In addition, by using receiver operating characteristic (ROC) analysis, we determined that the DC values in the regions with altered FC between the two groups can be used to differentiate subclinical depressive subjects from HCs. We suggest that decreased DC in subcortical and increased DC in cortical regions might be the neural substrates of subclinical depression.

关键词subclinical depression young adults magnetic resonance imaging resting-state functional connectivity degree centrality
DOI10.3389/fnhum.2016.00617
收录类别SCI
语种英语
项目资助者Science and Technology Planning Project of Guangdong Province(20138021800063) ; Science and Technology Planning Project of Guangzhou(2014J14100071) ; Strategic Priority Research Program (B) of the Chinese Academy of Sciences(XDB02030002) ; Beijing Training Project for Leading Talents in ST(Z151100000315020)
WOS研究方向Neurosciences & Neurology ; Psychology
WOS类目Neurosciences ; Psychology
WOS记录号WOS:000389378300001
WOS标题词Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
关键词[WOS]FUNCTIONAL CONNECTIVITY DENSITY ; ABNORMAL DEGREE CENTRALITY ; MODE NETWORK CONNECTIVITY ; MAJOR DEPRESSION ; DEFAULT-MODE ; SUBTHRESHOLD DEPRESSION ; UNIPOLAR DEPRESSION ; BIPOLAR DISORDER ; BRAIN NETWORKS ; AMYGDALA
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20929
专题中国科学院心理健康重点实验室
作者单位1.Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Guangzhou, Guangdong, Peoples R China
2.Guangzhou Med Univ, Fac Hlth Management, Guangzhou, Guangdong, Peoples R China
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
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GB/T 7714
Gao, Cuihua,Liu Wenhua,Liu, Yanli,et al. Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2016,10(0):1-9.
APA Gao, Cuihua.,Liu Wenhua.,Liu, Yanli.,Ruan, Xiuhang.,Chen, Xin.,...&Jiang, Xinqing.(2016).Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study.FRONTIERS IN HUMAN NEUROSCIENCE,10(0),1-9.
MLA Gao, Cuihua,et al."Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study".FRONTIERS IN HUMAN NEUROSCIENCE 10.0(2016):1-9.
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