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Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility
Piao, Chengji1,2,3; Deng, Xiaofei1,2; Wang, Xingyue1,2; Yuan, Yiran4; Liu, Zhengkui1; Liang, Jing1
2017-01-15
Source PublicationBEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
SubtypeArticle
Volume317Issue:0Pages:16-26
Abstract

The medial prefrontal cortex (mPFC) and its output area, the nucleus accumbens (NAc), are implicated in mediating attentional set-shifting. Patients with posttraumatic stress disorder (PTSD) exhibit difficulties in the disengagement of attention from traumatic cues, which is associated with impairments in set shifting ability. However, unknown is whether alterations in corticostriatal function underlie deficits in this behavioral flexibility in individuals with PTSD. An animal model of single prolonged stress (SPS) has been partially validated as a model for PTSD, in which SPS rats recapitulate the pathophysiological abnormalities and behavioral characteristics of PTSD. In the present study, we firstly found that exposure to SPS impaired the ability in the shift from visual-cue learning to place response discrimination in rats. Conversely, SPS induced no effect on a place-to-cue set-shifting performance. Based on SPS-impaired set-shifting model, we used Western blot and immunofluorescent approaches to clarify SPS-induced alternations in synaptic plasticity and neuronal activation in the mPFC and NAc. Rats that were subjected to SPS exhibited a large increase in pSer845-G1uA1 and total G1uA1 levels in the mPFC, while no significant change in the NAc. We further found that exposure to SPS significantly decreased c-Fos expression in the NAc core but not the shell after set-shifting behavior. Whereas, enhanced c-Fos expression was observed in prelimbic and infralimbic cortices. Collectively, these findings suggest that abnormal hyperactivity in the mPFC and dysfunction in the NAc core underlie long-term deficits in executive function after traumatic experience, which might play an important role in the development of PTSD symptoms. (C) 2016 Elsevier B.V. All rights reserved.

KeywordSingle prolonged stress Set-shifting Medial prefrontal cortex Nucleus accumbens
DOI10.1016/j.bbr.2016.09.017
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31271098 ; National Key Basic Research Program of China(2015CB553501) ; 31571108)
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000389086700002
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordSINGLE-PROLONGED STRESS ; RAT MODEL ; COGNITIVE FLEXIBILITY ; AMPA RECEPTORS ; SPATIAL MEMORY ; DISORDER ; PTSD ; PHOSPHORYLATION ; STRIATUM ; PLASTICITY
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20940
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Piao, Chengji,Deng, Xiaofei,Wang, Xingyue,et al. Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility[J]. BEHAVIOURAL BRAIN RESEARCH,2017,317(0):16-26.
APA Piao, Chengji,Deng, Xiaofei,Wang, Xingyue,Yuan, Yiran,Liu, Zhengkui,&Liang, Jing.(2017).Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility.BEHAVIOURAL BRAIN RESEARCH,317(0),16-26.
MLA Piao, Chengji,et al."Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility".BEHAVIOURAL BRAIN RESEARCH 317.0(2017):16-26.
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