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Alternative TitleThe Effects and Neurocorrelates of rTMS on Episodic Memory in Healthy Older Adults
Thesis Advisor李娟
Degree Grantor中国科学院研究生院
Place of Conferral北京
Degree Discipline心理学
Keyword老年人 联结记忆 重复经颅磁刺激(rTMS) 事件相关电位(ERP) 功能磁共振成像(fMRI)

方法:基于随机控制设计,对实验组健康老年人的右半球背外侧前额叶(rDLPFC)施加10 Hz的为期两周总共10次的rTMS干预,研究一采用联想学习测验,考察rTMS干预对老年人联结记忆的促进作用,以及干预效应的保持性;研究二采用来源记忆范式,结合ERP技术,以ERP新旧效应为指标,考察rTMS干预促进老年人联结记忆的提取机制;研究三采用fMRI技术考察rTMS干预促进老年人联结记忆的脑神经机制。

Other Abstract

Objective:Episodic memory is one of the cognitive domains that are vulnerable to aging. It included both item memory and associative memory. The associative memory demonstrated larger age effect than item memory, which might resulted from the deficit of the recollection as well as the disruption of the coordinated activity of large-scale brain networks. Luckily, the brain plasticity could be modulated to compensate for the cognitive decline. The repetitive transcranial magnetic stimulation (rTMS), a relatively noninvasive neuromodulatory technique, could directly modulate neural excitability in the stimulated cortical areas. The rTMS-altered neural activity could produce brain plastic changes, which is suggested to provide possibilities to alleviate cognitive decline. Here we are interested in whether the application of rTMS could reduce the associative deficit in the older adults who are cognitively intact. In addition, we also would like to explore the underlying neurocognitive mechanism of the rTMS effect on the associative memory in older adults.
Methods:This is a randomized controlled traildesign, with the intervention group received 10 sessions of 10 Hz rTMS applying on the right dorsolateral prefrontal cortex (rDLPFC), and the control group received 10 sessions of sham stimulation. The first study explored the rTMS effect on the associative memory performance as well as its maintenance effect. The second study explored the rTMS effect on the process of associative memory retrieval qualified by the ERPs old/new effects. The third study exploit the resting-state functional magnetic resonance imaging (fMRI) to explore the neural mechanism of rTMS-related associative memory enhancement.
Results:In study 1, behavioralresults showed that comparing with the control group, the rTMS significantly increased the associative memory performance and the enhanced effect still could be detected one month after the last stimulation session. In study 2, behavioral results showed that the rTMS significantly increased the source memory performance; the ERP results showed that during the retrieval phase, in comparisonwith the control group, the rTMS significantly increased the negative old/new effect which reflected the search and/oractivation of sensory-based information, rather than the left parietal old/new effectwhich reflected the process of recollection. In study 3, results showed that the large-scale network interactions among the rDLPFC and regions within the default mode network were modulated by the rTMS, which significantly contributed to the associative memory improvement.
Conclusions:These results suggest that rTMS could improve associative memory performance in the healthy older adults and the enhancement lasted for one month; the rTMS intervention facilitate the older adults to rely on the sensory-based information in retrieving source information in order to optimize their memory performance; the rTMS altered the large-scale brain network plasticity, which might underlie the associative memory improvement.

Subject Area认知神经科学
Document Type学位论文
Recommended Citation
GB/T 7714
任维聪. 重复经颅磁刺激对老年人情节记忆的促进及其认知神经机制[D]. 北京. 中国科学院研究生院,2016.
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