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Urine Formaldehyde Predicts Cognitive Impairment in Post-Stroke Dementia and Alzheimer's Disease
Tong, Zhiqian1,2; Wang, Weishan3; Luo, Wenhong4; Lv, Jihui3; Li, Hui4; Luo, Hongjun4; Jia, Jianping2; He, Rongqiao1,2,5; Zhiqian Tong; Rongqiao He
2017
发表期刊JOURNAL OF ALZHEIMERS DISEASE
通讯作者邮箱tzqbeida@163.com ; herq@sun5.ibp.ac.cn
ISSN1387-2877
文章类型Article
卷号55期号:3页码:1031-1038
摘要

Although Alzheimer's disease (AD) was first described over 100 years ago, there is still no suitable biomarker for diagnosing AD in easily collectable samples (e.g., blood plasma, saliva, and urine). Here, we investigated the relationship between morning urine formaldehyde concentration and cognitive impairment in patients with post-stroke dementia (PSD) or AD in this cross-sectional survey for 7 years. Cognitive abilities of the study participants (n = 577, four groups: 231 controls, 61 stroke, 65 PSD, and 220 AD) were assessed by Mini-Mental State Examination (MMSE). Morning urine formaldehyde concentrations were measured by high performance liquid chromatography (HPLC). Gender- and age-matched participants were selected from the four groups (n = 42 in each group). Both semicarbazide-sensitive amine oxidase (SSAO, a formaldehyde-generating enzyme) and formaldehyde levels in the blood and urine were analyzed by using an enzyme-linked immunosorbent assay (ELISA) and HPLC, respectively. We found that morning urine formaldehyde levels were inversely correlated with MMSE scores. The threshold value (the best Cut-Off value) of formaldehyde concentration for predicting cognitive impairment was 0.0418 mM in patients with PSD (Sensitivity: 92.3%; Specificity: 77.1%), and 0.0449 mM in patients with AD (Sensitivity: 94.1%; Specificity: 81.8%), respectively. The results of biochemical analysis revealed that the observed increase in urine formaldehyde resulted from an overexpression of SSAO in the blood. The findings suggest that measuring the concentration of formaldehyde in overnight fasting urine could be used as a potentially noninvasive method for evaluating the likelihood of ensuing cognitive impairment or dementia.

关键词Alzheimer's disease formaldehyde Mini-Mental State Examination norepinephrine post-stroke dementia semicarbazide-sensitive amine oxidase
DOI10.3233/JAD-160357
收录类别SCI
语种英语
项目资助者973-Project(2012CB911004 ; Scientific Research Common Program of Beijing Municipal Commission of Education(KM201510025014) ; Natural Scientific Foundation of CMU(2015ZR31) ; Natural Scientific Foundation of China NSFC(31171080) ; External Cooperation Program of BIC, Chinese Academy of Sciences(GJHZ201302) ; Key Research Program of the Chinese Academy of Sciences(20140909) ; Momentous Special Program of Beijing Research Institute of Brain Diseases(ZD2015-08) ; 2016YFC1306302)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000390766600015
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]SENSITIVE AMINE OXIDASE ; FLUORESCENT-PROBE ; ENDOGENOUS FORMALDEHYDE ; MEDIATED DEAMINATION ; LIVING CELLS ; IN-VIVO ; VASCULAR DAMAGE ; MEMORY DECLINE ; PROTEIN ; PLASMA
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20971
专题中国科学院心理健康重点实验室
通讯作者Zhiqian Tong; Rongqiao He
作者单位1.Capital Med Univ, Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100069, Peoples R China
2.Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
3.Beijing Geriatr Hosp, Beijing, Peoples R China
4.Shantou Univ, Coll Med, Cent Lab, Shantou, Guangdong, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
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GB/T 7714
Tong, Zhiqian,Wang, Weishan,Luo, Wenhong,et al. Urine Formaldehyde Predicts Cognitive Impairment in Post-Stroke Dementia and Alzheimer's Disease[J]. JOURNAL OF ALZHEIMERS DISEASE,2017,55(3):1031-1038.
APA Tong, Zhiqian.,Wang, Weishan.,Luo, Wenhong.,Lv, Jihui.,Li, Hui.,...&Rongqiao He.(2017).Urine Formaldehyde Predicts Cognitive Impairment in Post-Stroke Dementia and Alzheimer's Disease.JOURNAL OF ALZHEIMERS DISEASE,55(3),1031-1038.
MLA Tong, Zhiqian,et al."Urine Formaldehyde Predicts Cognitive Impairment in Post-Stroke Dementia and Alzheimer's Disease".JOURNAL OF ALZHEIMERS DISEASE 55.3(2017):1031-1038.
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