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Altered relationship between thickness and intrinsic activity amplitude in generalized tonic-clonic seizures
Liao, Wei1,2,3,4,5,6; Wang, Jue3,4,5,6; Xu, Ting7,8; Zhang, Zhiqiang1; Ji, Gong-Jun3,4,5,6,9; Xu, Qiang1; Wang, Zhengge10; Yang, Fang11; Zuo, Xi-Nian7,8; Qiu, Anqi12,13; Zang, Yu-Feng3,4,5,6; Lu, Guangming1; Chen, Huafu2; G. Lu; H. Chen
2016-12-01
Source PublicationSCIENCE BULLETIN
Correspondent Emailcjr.luguangming@vip.16.com ; chenhf@uestc.edu.cn
ISSN2095-9273
SubtypeArticle
Volume61Issue:24Pages:1865-1875
Abstract

A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity (iBA). However, the relationship between cortical thickness and iBA is unknown in intact and epileptic brains. To this end, we investigated the relationship between cortical thickness measured by high-resolution MRI and surface-based iBA derived from resting-state functional MRI in normal controls (n = 82) and patients with generalized tonic-clonic seizures (GTCS) only (n = 82). We demonstrated that the spatial distribution of cortical thickness negatively correlated with surface-based iBA amplitude at both whole-brain and within independent brain functional networks. In GTCS patients, spatial coupling between thickness and iBA amplitude decreased in the default mode, dorsal attention, and somatomotor networks. In addition, the vertex-wise across-subject thickness-iBA amplitude correspondence altered in the frontal and temporal lobes as well as in the precuneus in GTCS patients. The relationship between these two modalities can serve as a brain-based marker for detecting epileptogenic changes.

KeywordCortex thickness Generalized tonic-clonic seizures Intrinsic brain activity amplitude Morphometric-functional relationship Resting state
DOI10.1007/s11434-016-1201-0
Indexed BySCI
Language英语
Funding OrganizationNational High Technology Research and Development Program of China(2015AA020505) ; Natural Science Foundation of China(61533006 ; Fundamental Research Funds for the Central Universities(ZYGX2013Z004) ; China Postdoctoral Science Foundation(2013M532229) ; 81201155 ; 81301198 ; 81471653 ; 81401400 ; 81271553 ; 81422022)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000390668600005
WOS HeadingsScience & Technology
WOS KeywordJUVENILE MYOCLONIC EPILEPSY ; TEMPORAL-LOBE EPILEPSY ; HUMAN CEREBRAL-CORTEX ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; GLUCOSE-METABOLISM ; FRONTAL-LOBE ; STATE ; NETWORK ; ACTIVATION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20972
Collection中国科学院行为科学重点实验室
Corresponding AuthorG. Lu; H. Chen
Affiliation1.Nanjing Univ, Sch Med, Dept Med Imaging, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China
2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab Neuroinformat, Minist Educ,Ctr Informat BioMed, Chengdu 610054, Peoples R China
3.Hangzhou Normal Univ, Sch Educ, Dept Psychol, Hangzhou 310015, Zhejiang, Peoples R China
4.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou 310015, Zhejiang, Peoples R China
5.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou 310015, Zhejiang, Peoples R China
6.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 310015, Zhejiang, Peoples R China
7.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China
8.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
9.Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Hefei 230022, Peoples R China
10.Nanjing Univ, Affiliated Hosp, Dept Radiol, Nanjing Drum Tower Hosp, Nanjing 210002, Jiangsu, Peoples R China
11.Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China
12.Natl Univ Singapore, Dept Biomed Engn, Singapore 117583, Singapore
13.Natl Univ Singapore, Clin Imaging Res Ctr, Singapore 117583, Singapore
Recommended Citation
GB/T 7714
Liao, Wei,Wang, Jue,Xu, Ting,et al. Altered relationship between thickness and intrinsic activity amplitude in generalized tonic-clonic seizures[J]. SCIENCE BULLETIN,2016,61(24):1865-1875.
APA Liao, Wei.,Wang, Jue.,Xu, Ting.,Zhang, Zhiqiang.,Ji, Gong-Jun.,...&H. Chen.(2016).Altered relationship between thickness and intrinsic activity amplitude in generalized tonic-clonic seizures.SCIENCE BULLETIN,61(24),1865-1875.
MLA Liao, Wei,et al."Altered relationship between thickness and intrinsic activity amplitude in generalized tonic-clonic seizures".SCIENCE BULLETIN 61.24(2016):1865-1875.
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