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Altered relationship between thickness and intrinsic activity amplitude in generalized tonic-clonic seizures
Liao, Wei1,2,3,4,5,6; Wang, Jue3,4,5,6; Xu, Ting7,8; Zhang, Zhiqiang1; Ji, Gong-Jun3,4,5,6,9; Xu, Qiang1; Wang, Zhengge10; Yang, Fang11; Zuo, Xi-Nian7,8; Qiu, Anqi12,13; Zang, Yu-Feng3,4,5,6; Lu, Guangming1; Chen, Huafu2; G. Lu; H. Chen
2016-12-01
发表期刊SCIENCE BULLETIN
通讯作者邮箱cjr.luguangming@vip.16.com ; chenhf@uestc.edu.cn
ISSN2095-9273
文章类型Article
卷号61期号:24页码:1865-1875
摘要

A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity (iBA). However, the relationship between cortical thickness and iBA is unknown in intact and epileptic brains. To this end, we investigated the relationship between cortical thickness measured by high-resolution MRI and surface-based iBA derived from resting-state functional MRI in normal controls (n = 82) and patients with generalized tonic-clonic seizures (GTCS) only (n = 82). We demonstrated that the spatial distribution of cortical thickness negatively correlated with surface-based iBA amplitude at both whole-brain and within independent brain functional networks. In GTCS patients, spatial coupling between thickness and iBA amplitude decreased in the default mode, dorsal attention, and somatomotor networks. In addition, the vertex-wise across-subject thickness-iBA amplitude correspondence altered in the frontal and temporal lobes as well as in the precuneus in GTCS patients. The relationship between these two modalities can serve as a brain-based marker for detecting epileptogenic changes.

关键词Cortex thickness Generalized tonic-clonic seizures Intrinsic brain activity amplitude Morphometric-functional relationship Resting state
DOI10.1007/s11434-016-1201-0
收录类别SCI
语种英语
项目资助者National High Technology Research and Development Program of China(2015AA020505) ; Natural Science Foundation of China(61533006 ; Fundamental Research Funds for the Central Universities(ZYGX2013Z004) ; China Postdoctoral Science Foundation(2013M532229) ; 81201155 ; 81301198 ; 81471653 ; 81401400 ; 81271553 ; 81422022)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000390668600005
WOS标题词Science & Technology
关键词[WOS]JUVENILE MYOCLONIC EPILEPSY ; TEMPORAL-LOBE EPILEPSY ; HUMAN CEREBRAL-CORTEX ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; GLUCOSE-METABOLISM ; FRONTAL-LOBE ; STATE ; NETWORK ; ACTIVATION
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/20972
专题中国科学院行为科学重点实验室
通讯作者G. Lu; H. Chen
作者单位1.Nanjing Univ, Sch Med, Dept Med Imaging, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China
2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab Neuroinformat, Minist Educ,Ctr Informat BioMed, Chengdu 610054, Peoples R China
3.Hangzhou Normal Univ, Sch Educ, Dept Psychol, Hangzhou 310015, Zhejiang, Peoples R China
4.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou 310015, Zhejiang, Peoples R China
5.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou 310015, Zhejiang, Peoples R China
6.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 310015, Zhejiang, Peoples R China
7.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China
8.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
9.Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Hefei 230022, Peoples R China
10.Nanjing Univ, Affiliated Hosp, Dept Radiol, Nanjing Drum Tower Hosp, Nanjing 210002, Jiangsu, Peoples R China
11.Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China
12.Natl Univ Singapore, Dept Biomed Engn, Singapore 117583, Singapore
13.Natl Univ Singapore, Clin Imaging Res Ctr, Singapore 117583, Singapore
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GB/T 7714
Liao, Wei,Wang, Jue,Xu, Ting,et al. Altered relationship between thickness and intrinsic activity amplitude in generalized tonic-clonic seizures[J]. SCIENCE BULLETIN,2016,61(24):1865-1875.
APA Liao, Wei.,Wang, Jue.,Xu, Ting.,Zhang, Zhiqiang.,Ji, Gong-Jun.,...&H. Chen.(2016).Altered relationship between thickness and intrinsic activity amplitude in generalized tonic-clonic seizures.SCIENCE BULLETIN,61(24),1865-1875.
MLA Liao, Wei,et al."Altered relationship between thickness and intrinsic activity amplitude in generalized tonic-clonic seizures".SCIENCE BULLETIN 61.24(2016):1865-1875.
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