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Left Anterior Temporal Lobe and Bilateral Anterior Cingulate Cortex Are Semantic Hub Regions: Evidence from Behavior-Nodal Degree Mapping in Brain-Damaged Patients
Zhao, Ying1,2,3; Song, Luping4,5; Ding, Junhua1,2; Lin, Nan6; Wang, Qiang4,5; Du, Xiaoxia4,5; Sun, Rong4,5; Han, Zaizhu1,2
First AuthorZhao, Ying
2017-01-04
Source PublicationJOURNAL OF NEUROSCIENCE
Correspondent Emailzzhhan@bnu.edu.cn.
ISSN0270-6474
SubtypeArticle
Volume37Issue:1Pages:141-151
Abstract

The organizational principles of semantic memory in the human brain are still controversial. Although studies have shown that the semantic system contains hub regions that bind information from different sensorimotoric modalities to form concepts, it is unknown whether there are hub regions other than the anterior temporal lobe (ATL). Meanwhile, previous studies have rarely used network measurements to explore the hubs or correlated network indexes with semantic performance, although the most direct supportive evidence of hubs should come from the network perspective. To fill this gap, we correlated the brain-network index with semantic performance in 86 brain-damaged patients. We especially selected the nodal degree measure that reflects how well a node is connected in the network. The measure was calculated as the total number of connections of a given node with other nodes in the resting-state functional MRI network. Semantic ability was measured using the performance of both general and modality-specific (object form, color, motion, sound, manipulation, and function) semantic tasks. We found that the left ATL and the bilateral anterior cingulate cortex could be semantic hubs because the reduced nodal degree values of these regions could effectively predict the deficits in both general and modality-specific semantic performance. Moreover, the effects remained when the analyses were performed only in the patients who did not have lesions in these regions. The two hub regions might support semantic representations and executive control processes, respectively. These data provide empirical evidence for the distributed-plus-hub theory of semantic memory from the network perspective.

Keywordbrain-damaged patient graph-theoretical network analysis lesion-behavior correlation semantic hub semantic network
DOI10.1523/JNEUROSCI.1946-16.2017
Indexed BySCI ; SSCI
Language英语
Funding Organization973 Program(2013CB837300 ; National Natural Science Foundation of China(31271115 ; Major Project of the National Social Science Foundation(13ZD188) ; Fundamental Research Funds for the Central Universities(2014kJJCA07) ; 2014CB846100) ; 31571129 ; 81171019)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000391143500013
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordFUNCTIONAL CONNECTIVITY MRI ; GRADED SPECIALIZATION ; FEATURE INTEGRATION ; ANGULAR GYRUS ; DEMENTIA ; NETWORK ; MEMORY ; REPRESENTATIONS ; KNOWLEDGE ; COGNITION
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20981
Collection中国科学院行为科学重点实验室
Corresponding AuthorHan, Zaizhu
Affiliation1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Beijing Normal Univ, Int Data Grp, McGovern Inst Brain Res, Beijing 100875, Peoples R China
3.Univ Manchester, Sch Psychol Sci, Neurosci & Aphasia Res Unit, Manchester M13 9PL, Lancs, England
4.Capital Med Univ, Rehabil Coll, Beijing 100038, Peoples R China
5.Capital Med Univ, China Rehabil Res Ctr, Beijing 100038, Peoples R China
6.Chinese Acad Sci, Key Lab Behav Sci, Inst Psychol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Ying,Song, Luping,Ding, Junhua,et al. Left Anterior Temporal Lobe and Bilateral Anterior Cingulate Cortex Are Semantic Hub Regions: Evidence from Behavior-Nodal Degree Mapping in Brain-Damaged Patients[J]. JOURNAL OF NEUROSCIENCE,2017,37(1):141-151.
APA Zhao, Ying.,Song, Luping.,Ding, Junhua.,Lin, Nan.,Wang, Qiang.,...&Han, Zaizhu.(2017).Left Anterior Temporal Lobe and Bilateral Anterior Cingulate Cortex Are Semantic Hub Regions: Evidence from Behavior-Nodal Degree Mapping in Brain-Damaged Patients.JOURNAL OF NEUROSCIENCE,37(1),141-151.
MLA Zhao, Ying,et al."Left Anterior Temporal Lobe and Bilateral Anterior Cingulate Cortex Are Semantic Hub Regions: Evidence from Behavior-Nodal Degree Mapping in Brain-Damaged Patients".JOURNAL OF NEUROSCIENCE 37.1(2017):141-151.
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