PSYCH OpenIR  > 健康与遗传心理学研究室
Alternative TitleDisruption of large-scale brain networks in Alzheimer's disease and mild cognitive impairment
樊东琼1; 李锐2; 雷旭1; 喻婧1
First Author樊东琼
Source Publication心理科学进展
Contribution Rank2


Other Abstract

Resting state functional magnetic resonance imaging, as a method of non-invasive visual imaging and convenient data acquisition, has become an important measurement to explore brain functional variation in Alzheimer's disease and its symptomatic predementia phase. Recent studies demonstrated that patients with mild cognitive impairment have already showed the alteration of resting state networks, whereas more diffusion alteration was found in Alzheimer patients' networks. Specifically, with the pathological progression, the functional connectivity of patients' default mode network is gradually decreasing, whereas the connectivity of fronto-parietal network increased at first while decreased afterwards. In addition, the alteration of brain network and brain structure cannot simply be considered which happened first. More probably, the interactions between them bring up the cognitive impairment gradually. Future research needs to explore the sensitive neuro-pathway along the pathological progression, and further investigate the potential resting brain network biomarkers for clinical diagnosis and monitoring.

Keyword阿尔兹海默症 功能磁共振 轻度认知障碍 大尺度脑网络 静息态
Subject Area健康心理学
Indexed ByCSSCI
Funding Organization国家自然科学基金项目(31300856 ; 31571111 ; 31200847) ; 高等学校博士学科点专项科研基金(20130182120013) ; 中央高校基本科研业务费专项资金项目(SWU1509421)资助
Document Type期刊论文
Corresponding Author喻婧
Recommended Citation
GB/T 7714
樊东琼,李锐,雷旭,等. 阿尔兹海默症及轻度认知障碍静息态大尺度脑网络功能连接的改变[J]. 心理科学进展,2016(2):217-227.
APA 樊东琼,李锐,雷旭,&喻婧.(2016).阿尔兹海默症及轻度认知障碍静息态大尺度脑网络功能连接的改变.心理科学进展(2),217-227.
MLA 樊东琼,et al."阿尔兹海默症及轻度认知障碍静息态大尺度脑网络功能连接的改变".心理科学进展 .2(2016):217-227.
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